Polygenic Risk Scores for Bipolar Disorder: Progress and Perspectives.

Bipolar disorder (BD) is a common and highly heritable psychiatric disorder, the study of BD genetic characteristics can help with early prevention and individualized treatment. At the same time, BD is a highly heterogeneous polygenic genetic disorder with significant genetic overlap with other psychiatric disorders. In recent years, polygenic risk scores (PRS) derived from genome-wide association studies (GWAS) data have been widely used in genetic studies of various complex diseases and can be used to explore the genetic susceptibility of diseases.

Computational investigation of flow characteristics and particle deposition patterns in a realistic human airway model under different breathing conditions.

Airborne particle pollution causes a range of respiratory and cardiovascular disorders by entering the human respiratory system through the breathing process. The administration of pharmaceutical particles by inhalation is another effective way to treat pulmonary illnesses. Studying particle deposition in the respiratory system during human breathing is crucial to maintaining human health.

Modeling Event Propagation via Graph Biased Temporal Point Process.

Temporal point process is widely used for sequential data modeling. In this article, we focus on the problem of modeling sequential event propagation in graph, such as retweeting by social network users and news transmitting between websites. Given a collection of event propagation sequences, the conventional point process model considers only the event history, i.