Possible omadacycline induce acute pancreatitis: a case report and literature review.

Background: Omadacycline is a new generation of tetracycline antibiotics, and its clinical application is increasing. We report the first case of acute pancreatitis possibly induced by omadacycline.

Case Presentation: The patient was admitted to the emergency intensive care unit due to community-acquired pneumonia.

Fusion event mediated by IS903B between chromosome and plasmid in two MCR-9- and KPC-2-co-producing Klebsiella pneumoniae isolates.

Herein, we first isolated two MCR-9- and KPC-2-co-producing K. pneumoniae isolates. Notably, we observed a fusion event between the chromosome and plasmid, mediated by IS903B, in these two strains.

Navigating the immunometabolic heterogeneity of B cells in murine hepatocellular carcinoma at single cell resolution.

Induction of antitumor immunity is critical for the therapeutic efficacy of hepatocellular carcinoma (HCC) immunotherapy. The cellular metabolic state underpins the effector function of immune cells, yet our understanding of the phenotypic and metabolic heterogeneity of B cells within HCC microenvironment is poorly developed. Herein, we investigated the composition, distribution, phenotype, function and metabolic profiles of B-cell subsets in HCC and adjacent liver tissues from an orthotopic HCC mouse model using single-cell RNA sequencing (scRNA-seq).

Genetic characterization and virulence determinants of multidrug-resistant NDM-1-producing .

The emergence of carbapenemase significantly threatens public health. It is prevalent worldwide but rare in . Unlike most bacterial species, has two distinct flagella systems, which are closely related to biofilm formation.

Serum vitamin D levels and acute kidney injury: a systemic review and meta-analysis.

Numerous researches have evaluated the prevalence and clinical outcome of vitamin D deficiency in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). But the quantitative vitamin D status in acute kidney injury (AKI) patients and its relationship with prognosis remains controversial. We conducted this systemic review and meta-analysis to assess the quantitative difference of vitamin D status, including serum 25(OH) D and 1,25(OH)2D levels, between AKI patients and non-AKI controls, and further explore whether vitamin D status can be clearly correlated with the mortality of AKI.

Correlation of Impaired NF-B Activation in Sepsis-Induced Acute Lung Injury (ALI) in Diabetic Rats.

Background: The allergic lung inflammation is reduced in the diabetic rats which can be restored by treating it with insulin. As observed in multiple studies, the diabetic patients are more vulnerable to infections and their inflammatory reactions. There are confirmations on insulin and its effects control the inflammatory reactions.