Estrogen-mediated DNMT1 and DNMT3A recruitment by EZH2 silences miR-570-3p that contributes to papillary thyroid malignancy through DPP4.

Background: Papillary thyroid carcinoma (PTC) is a common endocrine malignancy. Studies have indicated that estrogen can regulate the expression of miRNAs in numerous malignancies. MiR-570-3p has been shown to have a regulatory function in various cancers.

Research space telescope deployable mechanism variable diameter internal drive device elastic collision contact characteristics in the inter-stage transition.

To address the problem of elastic contact discrepancies between a variable-diameter internal drive device and a non-continuous surface during the transition, caused by the vibrations resulting from elastic collision impact when the motion speed of the elastic body increases, the following steps were taken. First, we established models for elastic collision, impact, and vibration during the inter-stage transition to analyze how motion speed and preload affect the elastic contact characteristics between the two components. Subsequently, we employed the finite element method to further analyze the elastic contact state, using identical loads but varying motion speeds and radial preloads as boundary conditions.

PFKFB4 negatively regulated the expression of histone acetyltransferase GCN5 to mediate the tumorigenesis of thyroid cancer.

Thyroid cancer (TC) is the most common malignant endocrine tumor, and its incidence has progressively increased over several decades. Accumulating evidence has suggested that PFKFB4, a critical regulatory enzyme of glycolysis, has been implicated in various solid cancers. However, the exact effect of PFKFB4 on TC remains unclear.

[Preoperative evaluation of multi-slice spiral computed tomography angiography in laparoscopic radical operation for colorectal carcinoma].

Objective: To investigate the clinical application of 256 multi-slice spiral computed tomography angiography (MSCTA) technique in the preoperative evaluation of mesenteric angiography in order to provide a reference to vessel anatomy and dissociation in laparoscopic radical operation for colorectal carcinoma.

Methods: Clinical data of 50 patients with colorectal cancer who underwent preoperative MSCTA+FDCT and laparoscopic curative operation at our hospital from October 2013 to March 2015 were collected (MSCTA group). The evaluation item was visualization of mesenteric artery, which was compared with the findings under laparoscopic surgery.