Epigallocatechin-3-gallate activates the AMP-activated protein kinase signaling pathway to reduce lipid accumulation in canine hepatocytes.

Epigallocatechin-3-gallate (EGCG) plays a crucial role in hepatic lipid metabolism. However, the underlying regulatory mechanism of hepatic lipid metabolism by EGCG in canine is unclear. Primary canine hepatocytes were treated with EGCG (0.

Immune Regulation of RAW264.7 Cells by Flavonoids from via Activating the NF-B Signalling Pathway.

The current study aimed at investigating the effects of flavonoids from (FAC) on the proliferation, the contents, and gene expression levels of cytokines, secretion of surface stimulating factors, cell cycle, and the expression level of the NF-B signalling pathway in RAW264.7 cells. Our results revealed that compared with control group, the contents of IL-6, IL-1, TNF-, and NO and the mRNA expression levels of IL-6, IL-1, TNF-, and iNOS in FAC-treated groups significantly increased ( < 0.

Immune regulation mechanism of Astragaloside IV on RAW264.7 cells through activating the NF-κB/MAPK signaling pathway.

The present study was designed to investigate the effects of Astragaloside IV (ASIV) on the immune functions of RAW264.7 cells. Compared with control group, the concentrations of interleukin 1β (IL-1β), tumor necrosis factor α (TNF-α) and nitric oxide (NO) were higher in the 100μg/mL ASIV-treatment group.