Publications by authors named "Huanping Long"
Introduction: Focal segmental glomerulosclerosis (FSGS) is a common glomerulopathy with an unclear mechanism. The demand for FSGS clinical diagnostic biomarkers has not yet been met. Circular RNA (circRNA) is a novel non-coding RNA with multiple functions, but its diagnostic value for FSGS remains unexplored.
View Article and Find Full Text PDFBioinformatics analysis and experimental validation reveal the anti-ferroptosis effect of FZD7 in acute kidney injury.
Biochem Biophys Res Commun
January 2024
Background: Ferroptosis plays an important role in acute kidney injury (AKI), but the specific regulatory mechanism of ferroptosis in AKI remains unclear. This study is expected to analyze ferroptosis-related genes (FRGs) in AKI and explore their underlying mechanisms.
Results: A total of 479 differentially expressed genes (DEGs), including 196 up-regulated genes and 283 down-regulated genes were identified in the AKI chip GSE30718.
Article Synopsis
- The article focuses on identifying key genes that impact the prognosis and radiosensitivity of lung adenocarcinoma (LUAD), specifically investigating the gene PKMYT1.
- Using various bioinformatics tools and methods, researchers identified 14 significant genes and confirmed that PKMYT1 is overexpressed in LUAD, affecting how cancer cells respond to radiation treatment.
- The study concludes that silencing PKMYT1 can enhance tumor cell sensitivity to radiation, suggesting it could be a potential therapeutic target for improving LUAD treatment outcomes.