Non-Covalent Interaction Induced Supramolecular Precipitate with Hetero-Motif Polyionic Junction for Durable Antimicrobial Activity and Infected Wound Healing.

The advent of the COVID-19 pandemic has underscored the pressing demand for antimicrobial materials that offer both durability and efficacy. Herein, the successful design and fabrication of a "water-insoluble" supramolecular precipitate is reported through the "bottom-up" assembly of polyanion sodium alginate (SA) with the antimicrobial motifs A2G and Cu. This innovative hetero-motif polyionic junction leverages a network of hydrogen bonds aligning with electrostatic interactions, and hydrophobic effects to mitigate the rapid release of active components, providing exceptional long-term antimicrobial efficacy against Staphylococcus aureus (S.

A win-win scenario for antibacterial activity and skin mildness of cationic surfactants based on the modulation of host-guest supramolecular conformation.

The commercial cationic surfactants (CSAa) with quaternary ammonium (QA) groups have proved to be broad-spectrum bactericide against bacteria, fungi, and viruses. Nevertheless, they inevitably exhibit potent irritation on the skin. In this work, we systematically investigated the regulatory mechanism of the host-guest supramolecular conformation with β-cyclodextrin (β-CD) on the bactericidal performance and skin irritation of CSAa with different head groups and chain lengths.

Nesfatin-1 alleviates high glucose/high lipid-induced injury of trophoblast cells during gestational diabetes mellitus.

Gestational diabetes mellitus (GDM) is a common disease in pregnant women, imposing risks on both mother and fetus. Dysregulated nesfatin-1 has been observed in women with GDM, but the specific role of nesfatin-1 underlying the pathological process of GDM is unclear. The main objective of this study is to investigate the role and the molecular mechanism of nesfatin-1 in GDM.

[Effect of human bone morphogenetic protein 2, 3, 6, and 12 on osteosarcoma cell line UMR106].

Objective: To investigate the effect of human bone morphogenetic protein (hBMPs) 2/3/6 and 12 on osteosarcoma cell UMR106.

Methods: Adenovirus-BMP2/3/6 and 12 (AdBMP2/3/6 and12) were used to treat the cell line. Their proliferation, apoptosis, and transmigration were detected by Trypan blue exclusion test, TdT-mediated biotinylated-dUTP nick end labeling (TUNEL), acridine orange-ethidium bromide (AO/EB) double fluorescent dye staining, and transwell-room test, respectively.