Impact of diabetes mellitus on the risk of Alzheimer's disease: a mendelian randomization study.

Background: The impact of diabetes on the risk of Alzheimer's disease remains uncertain. This study aimed to explore this issue from multiple perspectives by using the Mendelian randomization (MR) approach.

Methods: Instrumental variables for predicting six diabetic traits (including insulin and blood glucose), eight metabolic risk factors for diabetes (including total cholesterol and blood pressure), and seven diabetic genes were extracted from their summary data.

A naturally occurring point mutation in the hyaluronidase gene () of UAMS-1 results in reduced enzymatic activity.

Hyaluronic acid is a high-molecular-weight polysaccharide that is widely distributed in animal tissues. Bacterial hyaluronidases degrade hyaluronic acid as secreted enzymes and have been shown to contribute to infection. UAMS-1 is a clinical isolate that codes for two hyaluronidases ( and ).

The Fluorescence Property of Zirconium-Based MOFs Adsorbed Sulforhodamine B.

Sulforhodamine B (SRB) is widely utilized for cell staining and laser field. But its application is limited by aggregation-caused quenching (ACQ). In this work, we evaluated the use of UiO-66 and UiO-67 of Zr-based metal organic frameworks (Zr-MOFs) as the host to adsorb SRB molecules due to the high stabily and good loading capacity of Zr-MOFs.

Improvement of the mechanical property and thermal stability of polypropylene/recycled rubber composite by chemical modification and physical blending.

The binary blend materials containing the modified recycled rubber powder with maleic a hydride modified polypropylene thermoplastic elastomer were prepared by dynamic vulcanization and blended with a variety of additives such as activated agent, accelerator, solubilizer, and the crosslinking agent. The thermal properties and mechanical properties including tensile strengths and impact strengths of pristine rubber, polypropylene and their corresponding binary blends were investigated. Besides, the effects of the amount of rubber powder, polypropylene, crosslinking agent, accelerator, activator, and solvent were studied and the microstructures of the pristine rubber, pristine polypropylene, and their corresponding binary blends were observed by scanning electron microscopy.

Ligands-Coordinated Zr-Based MOF for Wastewater Treatment.

Isostructural zirconium-based metal⁻organic frameworks (Zr-MOFs) have attracted the attention of researchers because of their remarkable stability at high temperatures and high pressures and their chemical stabilities against acids and bases. Due to this stability, Zr-MOFs can be utilized in adsorption research, and the adsorption performance of a Zr-MOF depends on the pore size and the surroundings of the MOF. In this study, as the dimensions changed and the adsorption was carried out, the Zr-MOF material remained stable, and the adsorption of the best state was achieved at 235 mg/g.

Presence and Persistence of in Water: The Impact on Microbial Quality of Water and Food Safety.

ranks high among the pathogens causing foodborne disease outbreaks. According to the Centers for Disease Control and Prevention, contributed to about 53.4% of all foodborne disease outbreaks from 2006 to 2017, and approximately 32.

Multiplex real-time PCR assay for detection of Escherichia coli O157:H7 and screening for non-O157 Shiga toxin-producing E. coli.

Background: Shiga toxin-producing Escherichia coli (STEC), including E. coli O157:H7, are responsible for numerous foodborne outbreaks annually worldwide. E.

Adsorption Behavior of High Stable Zr-Based MOFs for the Removal of Acid Organic Dye from Water.

Zirconium based metal organic frameworks (Zr-MOFs) have become popular in engineering studies due to their high mechanical stability, thermostability and chemical stability. In our work, by using a theoretical kinetic adsorption isotherm, we can exert MOFs to an acid dye adsorption process, experimentally exploring the adsorption of MOFs, their external behavior and internal mechanism. The results indicate their spontaneous and endothermic nature, and the maximum adsorption capacity of this material for acid orange 7 (AO7) could be up to 358 mg·g at 318 K, estimated by the Langmuir isotherm model.

Chitosan/silica coated carbon nanotubes composite proton exchange membranes for fuel cell applications.

Silica-coated carbon nanotubes (SCNTs), which were obtained by a simple sol-gel method, were utilized in preparation of chitosan/SCNTs (CS/SCNTs) composite membranes. The thermal and oxidative stability, morphology, mechanical properties, water uptake and proton conductivity of CS/SCNTs composite membranes were investigated. The insulated and hydrophilic silica layer coated on CNTs eliminates the risk of electronic short-circuiting and enhances the interaction between SCNTs and chitosan to ensure the homogenous dispersion of SCNTs, although the water uptake of CS/SCNTs membranes is reduced owing to the decrease of the effective number of the amino functional groups of chitosan.

Genomic evidence reveals numerous Salmonella enterica serovar Newport reintroduction events in Suwannee watershed irrigation ponds.

Our previous work indicated a predominance (56.8%) of Salmonella enterica serovar Newport among isolates recovered from irrigation ponds used in produce farms over a 2-year period (B. Li et al.

Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1) production and Lactobacillus species growth in a defined medium simulating vaginal secretions.

Lactobacillus species are commensal with the healthy vaginal environment and inhibit the growth of many pathogenic bacteria in the vaginal tract by a variety of mechanisms, such as the production of hydrogen peroxide, organic acids, and antimicrobial substances. Simulation of the vaginal environment is crucial for proper investigation of the effects of Lactobacillus species on pathogenic bacteria. In this study, we modified a medium used to simulate vaginal secretions to improve the growth of toxic shock syndrome toxin-1 (TSST-1)-producing Staphylococcus aureus clinical strains and Lactobacillus species so that interactions between these bacteria may be examined.

Diversity and antimicrobial resistance of Salmonella enterica isolates from surface water in Southeastern United States.

A study of prevalence, diversity, and antimicrobial resistance of Salmonella enterica in surface water in the southeastern United States was conducted. A new scheme was developed for recovery of Salmonella from irrigation pond water and compared with the FDA's Bacteriological Analytical Manual (8th ed., 2014) (BAM) method.

Hyaluronidase expression and biofilm involvement in Staphylococcus aureus UAMS-1 and its sarA, agr and sarA agr regulatory mutants.

In a previous study, two proteins identified as hyaluronidases were detected in spent media by MS and found to be in greater quantity in the sarA and sarA agr mutant strains when compared with the parent and agr mutant strains of Staphylococcus aureus UAMS-1. In the present study, spent media and total RNA were isolated from UAMS-1 and its regulatory mutants and analysed for hyaluronidase activity and steady-state hyaluronidase (hysA) RNA message levels. Hyaluronidase activity was observed throughout all time points examined regardless of the regulatory effects of sarA and agr but activity was always substantially higher in the sarA and sarA agr mutant strains than in the UAMS-1 parent and agr mutant strains.

Inhibition of Staphylococcus aureus by lysostaphin-expressing Lactobacillus plantarum WCFS1 in a modified genital tract secretion medium.

Lactobacillus species are a predominant member of the vaginal microflora and are critical in maintaining an acidic vaginal environment thought to contribute to the prevention of a number of urogenital diseases. However, during menstruation the pH of the vaginal environment increases to neutrality, a pH conducive for Staphylococcus aureus proliferation and the production of toxic shock syndrome toxin 1 (TSST-1) in susceptible women. In order to generate Lactobacillus species capable of expressing lysostaphin (an endopeptidase that cleaves the cell wall of S.

Pyramiding unmarked deletions in Ralstonia solanacearum shows that secreted proteins in addition to plant cell-wall-degrading enzymes contribute to virulence.

Ralstonia solanacearum, like many phytopathogenic bacteria, makes multiple extracellular plant cell-wall-degrading enzymes (CWDE), some of which contribute to its ability to cause wilt disease. CWDE and many other proteins are secreted to the milieu via the highly conserved type II protein secretion system (T2SS). R.

Ralstonia solanacearum requires type 4 pili to adhere to multiple surfaces and for natural transformation and virulence.

As reported previously for Ralstonia solanacearum strain GMI1000, wild-type strains AW1 and K60 were shown to produce Hrp pili. AW1 and K60 mutants lacking Hrp pili still exhibited twitching motility, which requires type 4 pili (Tfp), and electron microscopy revealed that they still made flexuous polar pili. Twitching-positive cells had an extracellular 17 kDa protein that was associated with piliation, and an internal 43-amino-acid sequence of this protein was typical of type 4 pilins.