Publications by authors named "Huanlei Zhang"

Article Synopsis
  • * Recent research has focused on targeting OX40/OX40L as potential therapies for diseases driven by T cells, gaining attention in the scientific community.
  • * This paper discusses how OX40/OX40L are involved in allergic diseases and summarizes advancements in clinical treatments that aim to exploit this signaling pathway.
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Objective: To explore the differences between clinical features and computed tomography (CT) findings of early-stage glottic cancer (EGC) with or without recurrence after transoral laser microsurgery (TLM) and to establish a preoperative nomogram to predict postoperative recurrence.

Methods: The clinical and CT features of 168 consecutive patients with EGC with or without recurrence were analyzed retrospectively. Multivariate logistic regression analysis was used to determine the independent predictors of recurrence.

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This study systematically explores the impact of the anodic flow field design on the transport of O bubble and subsequent energy efficiency in electrolysis devices. Two distinct configurations, namely a conventional serpentine flow panel and an interdigitated flow panel, are integrated at the anode side of the electrolyzer. The interdigitated flow field exhibits superior performance in both alkaline water splitting and CO reduction despite the experience of an increased pressure drop.

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Objective: To measure the relative T1 (rT1) value in different hypo-perfused regions after ischemic stroke using T1 mapping derived by Strategically Acquired Gradient Echo (STAGE) and assess its relationship with onset time and severity of ischemia.

Materials And Methods: Sixty-three patients with acute anterior circulation ischemic stroke from 2017 to 2022 who underwent STAGE, diffusion weighted imaging (DWI) and dynamic susceptibility contrast perfusion weighted imaging (DSC-PWI) within 7 days were retrospectively enrolled. The areas with reduced diffusion and hypo-perfusion were segmented based on apparent diffusion coefficient (ADC) value < 0.

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Background And Objectives: Central cervical lymph node metastasis (CLNM) is considered a risk factor for recurrence in patients with papillary thyroid carcinoma (PTC). Traditional machine learning models suffered from "black-box" problems, which could not exactly explain the interactive effects of the risk factors. We aimed to develop an eXtreme Gradient Boosting (XGBoost) model to assess CLNM, including positive and negative effects.

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Objective: To explore the value of a predictive model combining the multiparametric magnetic resonance imaging (mpMRI) radiomics score (RAD-score), clinicopathologic features, and morphologic features for the pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in invasive breast carcinoma of no specific type (IBC-NST).

Methods: We enrolled, retrospectively and consecutively, 206 women with IBC-NST who underwent surgery after NAC and obtained pathological results from August 2018 to October 2021. Four RAD-scores were constructed for predicting the pCR based on fat-suppression T2-weighted imaging (FS-T2WI), diffusion-weighted imaging (DWI), contrast-enhanced T1-weighted imaging (T1WI+C) and their combination, which was called mpMRI.

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This study aimed to predict progression-free survival (PFS) in patients with early glottic cancer using radiomic features on dual-energy computed tomography iodine maps. Radiomic features were extracted from arterial and venous phase iodine maps, and radiomic risk scores were determined by univariate Cox proportional hazards regression analysis and least absolute shrinkage and selection operator regression with tenfold cross-validation. The Kaplan-Meier method was used to evaluate the association between radiomic risk scores and PFS.

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Objectives: To establish and validate a predictive model integrating with clinical and dual-energy CT (DECT) variables for individual recurrence-free survival (RFS) prediction in early-stage glottic laryngeal cancer (EGLC) after larynx-preserving surgery.

Methods: This retrospective study included 212 consecutive patients with EGLC who underwent DECT before larynx-preserving surgery between January 2015 and December 2018. Using Cox proportional hazard regression model to determine independent predictors for RFS and presented on a nomogram.

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Three-dimensional (3D) printed, hierarchically porous nickel molybdenum (NiMo) electrocatalysts were synthesized and evaluated in a flow-through configuration for the hydrogen evolution reaction (HER) in 1.0 M KOH(aq) in a simple electrochemical H-cell. 3D NiMo electrodes possess hierarchically porous structures because of the resol-based aerogel precursor, which generates superporous carbon aerogel as a catalyst support.

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Background: Predicting the possibility of ipsilateral lateral cervical lymph node metastasis (ipsi-LLNM) was crucial to the operation plan for patients with papillary thyroid carcinoma (PTC). This study aimed to investigate the independent risk factors for ipsi-LLNM in PTC patients by combining dual-energy computed tomography (DECT) with thyroid function indicators.

Methods: We retrospectively enrolled 406 patients with a pathological diagnosis of PTC from Jan 2016 to Dec 2019.

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Cannabaceae is an economically important family that includes ten genera and ca. 117 accepted species. To explore the structure and size variation of their plastomes, we sequenced ten plastomes representing all ten genera of Cannabaceae.

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Objective: We performed a meta-analysis to compare the diagnostic efficacy of FDG PET/PET-CT and bone scintigraphy (BS) for diagnosing bone metastatic cancers in nasopharyngeal cancer patients.

Results: 6 studies (1238 patients) fulfilled the inclusion criteria. The pooled sensitivities for FDG PET/PET-CT and BS were 0.

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Synopsis of recent research by authors named "Huanlei Zhang"

  • - Huanlei Zhang's research primarily focuses on the intersection of medical imaging, electrochemical processes, and immune regulation, exploring innovative approaches to enhance diagnostic and therapeutic efficacy in various health conditions.
  • - Recent findings highlight the role of OX40/OX40L in allergic diseases, the development of predictive models for cancer recurrence based on imaging data, and advancements in hydrogen evolution catalysis, showcasing Zhang's multidisciplinary expertise.
  • - Zhang's studies emphasize the importance of integrating machine learning techniques and imaging biomarkers to improve predictive accuracy in cancer outcomes, as well as the optimization of electrochemical systems for energy efficiency, contributing valuable insights to both the medical and engineering fields.