Publications by authors named "Huanhao Zhang"
Front Genet
September 2024
Article Synopsis
- Previous studies have hinted at a link between Type 1 diabetes (T1D) and autoimmune diseases (AIDs), but a direct causal relationship has not been clearly established; this study aims to clarify that connection using GWAS databases.
- The research uses a two-sample Mendelian Randomization approach with comprehensive methods to analyze the relationships between T1D and diseases like systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and inflammatory bowel disease (IBD).
- Results suggest a potential causal association between T1D and SLE (OR = 1.37) as well as RA (OR = 1.32), but no significant association was found between T1D and I
Front Immunol
December 2023
Article Synopsis
- A study was conducted to investigate the potential causal relationship between systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD) using two-sample Mendelian randomization analysis with existing genetic data from European and East Asian populations.
- Results indicated a negative causal relationship in Europeans, suggesting that genetic susceptibility to SLE may actually reduce the risk for both overall IBD and ulcerative colitis, although no such relationship was found for Crohn's disease.
- In contrast, the analysis revealed no causal relationship between SLE and IBD in East Asian populations, highlighting the need for more research to understand these differences across populations.
