Comparative study of the interactions between bisphenol analogues and serum albumins by electrospray mass spectrometry and fluorescence spectroscopy.

Rationale: Bisphenol A and its alternatives are widely used in common consumer products and are known as environmental endocrine disrupting chemicals. Five bisphenol analogues, namely, tetrabromobisphenol A (TBBPA), tetrachlorobisphenol A (TCBPA), 4,4'-sulfonyldiphenol (BPS), bisphenol A (BPA) and 4,4'-hexafluoroisopropylidenediphenol (BPAF), were selected to study their interactions with serum albumins, aiming at a better understanding of the toxicological mechanisms of bisphenol compounds.

Methods: The interactions between human and bovine serum albumins (HSA and BSA) with these five compounds were investigated by electrospray ionization mass spectrometry (ESI-MS).