Publications by authors named "Huangjie Zhang"
Background: Reliable predictive data are crucial for making accurate treatment decisions in glioma patients, but it can be challenging to obtain due to limited information in many cases. Numerous research studies have indicated the involvement of cyclic adenosine monophosphate (cAMP)-response element binding protein (CREBBP) and E1A binding protein p300 (EP300) in tumorigenesis and tumor progression across various types.
Methods: The messenger RNA (mRNA) expression levels of CREBBP and EP300 were retrospectively analyzed in 17 grade-3 glioma patients.
Polarization control is a major issue in topological quantum optics that limits reliable generation and transmission of quantum states. This study presents what we believe to be a novel topological photonic crystal design that provides topological protection for biphoton pairs for both TE and TM polarization. By well-designed cell configurations within the lattice, two topological boundaries emerge that can accommodate TM and TE modes at the same time.
View Article and Find Full Text PDFAnoikis acts as a programmed cell death that is activated during carcinogenesis to remove undetected cells isolated from ECM. Further anoikis based risk stratification is expected to provide a deeper understanding of stomach adenocarcinoma (STAD) carcinogenesis. The information of STAD patients were acquired from TCGA dataset.
View Article and Find Full Text PDFMachine learning-based metabolism-related genes signature and immune infiltration landscape in diabetic nephropathy.
Front Endocrinol (Lausanne)
December 2022
Background: To identify the diagnostic biomarkers of metabolism-related genes (MRGs), and investigate the association of the MRGs and immune infiltration landscape in diabetic nephropathy (DN).
Methods: The transcriptome matrix was downloaded from the GEO database. R package "limma" was utilized to identify the differential expressed MRGs (DE-MRGs) of HC and DN samples.
Article Synopsis
- - Gliomas are challenging brain cancers that are hard to treat, often requiring surgery and radiation, but these cells frequently resist radiation, leading to poor outcomes.
- - The study explored how borneol can enhance the effectiveness of radiation therapy on glioma cells, finding that it significantly slows down cell growth and promotes autophagy (the process of clearing out damaged cells).
- - Borneol was shown to disrupt key signaling pathways related to tumor growth, specifically the mTORC1/eIF4E/HIF-1α axis, thereby increasing the levels of proteins associated with autophagy (beclin-1 and LC3) and reducing glioma cell proliferation.