Publications by authors named "Huanghuang Zhu"
Article Synopsis
- - Accurate identification of tumor-derived exosomes is essential for improving cancer diagnosis and treatment, but their diversity makes this difficult.
- - The new CAPTURE strategy uses curvature-sensing peptides and aptamers to specifically identify and quantify PD-L1 exosomes in plasma samples.
- - CAPTURE demonstrated 100% specificity in distinguishing colorectal cancer patients from healthy individuals, offering a promising method for noninvasive cancer diagnosis.
Article Synopsis
- * The study introduces a new method using aptamer-functionalized polydopamine nanospheres (Apt-PDANS) that bind specifically to proteins on sEVs, facilitating their fast isolation by filtration.
- * This innovative approach allows for rapid, sensitive detection of sEVs with the ability to visually analyze them without complex equipment, demonstrating potential applications in monitoring diseases like cancer.
Proteins as crucial components of cells are responsible for the majority of cellular processes. Sensitive and efficient protein detection enables a more accurate and comprehensive investigation of cellular phenotypes and life activities. Here, a protein sequencing method with high multiplexing, high throughput, high cell utilization, and integration based on digital microfluidics (DMF-Protein-seq) is proposed, which transforms protein information into DNA sequencing readout via DNA-tagged antibodies and labels single cells with unique cell barcodes.
View Article and Find Full Text PDFHalf of the world's population experiences Helicobacter pylori (H. pylori) infection, which is a main cause of gastritis, duodenal and gastric ulcer, and gastric cancers. In the current study, we investigated the potential role of compound 13 (C13), a novel α1-selective small molecule activator of AMP-activated protein kinase (AMPK), against H.
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