Research on the improvement path of grassroots social governance innovation performance in China--Qualitative comparative analysis based on 35 cases.

With the rapid development of China's economy and society, the innovation of grassroots social governance has become increasingly important. This paper constructs 35 grassroots social governance innovation samples. Using the TOE theoretical framework and a fuzzy set qualitative comparative analysis (fsQCA), this paper analyzes the joint effects and interactive relationships of multiple factors on grassroots social governance innovation performance from three dimensions: technology, organization, and environment.

A self-assembling peptide inhibits the growth and function of fungi a wrapping strategy.

Fungal infections contribute substantially to human morbidity and mortality. A particular concern is the high rate of mortality associated with invasive fungal infections, which often exceeds 50.0% despite the availability of several antifungal drugs.

Binding-induced fibrillogenesis peptide inhibits RANKL-mediated osteoclast activation against osteoporosis.

Osteoporosis is primarily driven by an imbalance between bone resorption and formation, stemming from enhanced osteoclast activity during bone remodeling. At the crux of this mechanism lies the pivotal RANK-RANKL-OPG axis. In our study, we designed two binding-induced fibrillogenesis (BIF) peptides, namely BIFP and BIFY, targeting RANK and RANKL, respectively.

A Biomimetic Peptide Functions as Specific Extracellular Matrix for Quiescence of Stem Cells against Intervertebral Disc Degeneration.

Maintaining quiescence of stem cells is a potential way to decrease cell nutrition demand for restoring the organization. Herein, a biomimetic peptide to maintain quiescence of stem cells through C-X-C motif chemokine ligand 8 (CXCL8)-C-X-C motif chemokine receptor 1 (CXCR1) pathway against intervertebral disc degeneration (IVDD) is developed. First, it is confirmed that quiescence can be induced via inhibiting phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway in nucleus pulposus stem cells (NPSCs).

Resilience assessment and obstacle factor analysis of urban areas facing waterlogging disasters: a case study of Shanghai, China.

In recent years, accelerated global warming, rainstorms, typhoons, and other natural disasters have been frequently observed, bringing immeasurable direct and indirect economic losses to urban areas. Determining how to further enhance the resilience of urban areas has become an important topic in economic and social development. Therefore, based on waterlogging scenarios, this study uses a more accurate research method combining the subjective evaluation AHP (analytic hierarchy process) method and objective evaluation TOPSIS (Technique for Order of Preference by Similarity to Ideal Solution) method to evaluate the urban resilience of 16 districts of the Shanghai megacity as the research objects and divides the resilience grade results using the ArcGIS natural breakpoint method.

An intelligent peptide recognizes and traps to inhibit macrophage phagocytosis.

Tuberculosis is a major public health concern worldwide, and it is a serious threat to human health for a long period. Macrophage phagocytosis of () is a crucial process for granuloma formation, which shelters the bacteria and gives them an opportunity for re-activation and spread. Herein, we report an intelligent anti-microbial peptide that can recognize and trap the , inhibiting the macrophage phagocytosis process.

Smart Peptide Defense Web In Situ Connects for Continuous Interception of IgE against Allergic Rhinitis.

Allergic rhinitis (AR) is a chronic inflammatory reaction by immunoglobulin E (IgE) mediators after individual contact with allergens. It affects 10-40% of the world's population and reduces the quality of life. Long-term symptoms of rhinitis can cause inflammation to spread and trigger asthma, which can harm human health.

Association between serum phosphate and mortality in critically ill patients: a large retrospective cohort study.

Objectives: This research aims to explore the impact of serum phosphate on the mortality of critically ill patients.

Design: A retrospective large cohort study.

Setting: Our data were extracted from a publicly accessible database named 'Multiparameter Intelligent Monitoring in Intensive Care Database III'.

Alcohol-soluble electron-transport small molecule for fully solution-processed multilayer white electrophosphorescent devices.

A novel alcohol-soluble electron-transport material was designed and synthesized. This material not only possesses a high triplet energy and a low HOMO level but also exhibits excellent electron-transport properties and good film-forming ability. Efficient fully solution-processed multilayer white electrophosphorescent devices have been fabricated by using this alcohol-processable material as an orthogonal electron-transport layer.