Publications by authors named "Huang-Xi Chen"
Activation of the NF-κB pathway is strictly regulated to prevent excessive inflammatory and immune responses. In a well-known negative feedback model, IκBα-dependent NF-κB termination is a delayed response pattern in the later stage of activation, and the mechanisms mediating the rapid termination of active NF-κB remain unclear. Here, we showed IκBα-independent rapid termination of nuclear NF-κB mediated by CLK2, which negatively regulated active NF-κB by phosphorylating the RelA/p65 subunit of NF-κB at Ser180 in the nucleus to limit its transcriptional activation through degradation and nuclear export.
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- - The Monkey-pod tree (Jack Benth.) is a perennial tree from the Fabaceae family, commonly found in Guangdong, Fujian, and Zhejiang provinces in China, and used in traditional medicine for heat toxicity symptoms.
- - In 2018, around 30 Monkey-pod trees in a commercial plantation in Huizhou, Guangdong showed dieback symptoms, with signs of ambrosia beetle infestation, including white sawdust exudates and discoloration near exit holes.
- - Pathogen identification involved collecting samples from infected trees, culturing them on potato dextrose agar, and isolating 37 fungal colonies, which were analyzed for morphological characteristics and genetic sequences indicating the involvement of a specific fungus associated with
MAVS is essential for antiviral immunity, but the molecular mechanisms responsible for its tight regulation remain poorly understood. Here, we show that NLK inhibits the antiviral immune response during viral infection by targeting MAVS for degradation. NLK depletion promotes virus-induced antiviral cytokine production and decreases viral replication, which is potently rescued by the reintroduction of NLK.
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