Discovery of quorum sensing inhibitors against Pseudomonas aeruginosa from Aspergillus sp. NB12.

Twelve secondary metabolites, including two undescribed steroids, aspesterols A (1) and B (2) and three new triterpenoids, aspertrinoids A-C (5-7), were isolated from the endophytic fungus Aspergillus sp. NB12 obtained from Hypericum patulum. Structurally, aspertrinoids A-C (5-7) were 30-norlanostane triterpenoids with a C9 side-chain moiety and a hemiacetal moiety formed between C-3 and C-19.

PfPAH1-1 gene enhances plant tolerance to low phosphate stress by modulating cell membrane lipid remodeling.

Phosphate (Pi) is an essential macroelement for plant survival, and Pi deficiency triggers membrane lipid remodeling that promotes the conversion of phospholipids to galactolipids. Perilla frutescens is a traditional food and medicinal plant, widely used in food, pharmaceutical, and industrial sectors. Importantly, Perilla seed oil is rich in polyunsaturated fatty acids (PUFAs) and are considered an ideal source of healthy vegetables oils for humans.

Three-Dimensional Reconstruction-Characterization of Polymeric Membranes: A Review.

Polymeric membranes serve as vital separation materials in diverse energy and environmental applications. A comprehensive understanding of three-dimensional (3D) structures of membranes is critical to performance evaluation and future design. Such quantitative 3D structural information is beyond the limit of most employed conventional two-dimentional characterization techniques such as scanning electron microscopy.

Observation of Λ_{c}^{+}→Λa_{0}(980)^{+} and Evidence for Σ(1380)^{+} in Λ_{c}^{+}→Λπ^{+}η.

Based on 6.1  fb^{-1} of e^{+}e^{-} annihilation data collected at center-of-mass energies from 4.600 to 4.

Test of Lepton Universality and Measurement of the Form Factors of D^{0}→K^{*}(892)^{-}μ^{+}ν_{μ}.

One of the main goals of studying semileptonic decays in flavor physics is to gain a better understanding of hadronic transitions in the nonperturbative region of Quantum Chromodynamics. This involves measuring Cabibbo-Kobayashi-Maskawa matrix elements, understanding form factors, and comparing them with theoretical predictions. We report a first study of the semileptonic decay D^{0}→K^{-}π^{0}μ^{+}ν_{μ} by analyzing an e^{+}e^{-} annihilation data sample of 7.

Study of D_{s}^{+}→f_{0}(980)ρ^{+} and ϕπ^{+} Decays through D_{s}^{+}→π^{+}π^{+}π^{-}π^{0}.

We perform the first amplitude analysis of D_{s}^{+}→π^{+}π^{+}π^{-}π^{0} decays based on data samples of electron-positron collisions recorded with the BESIII detector at center-of-mass energies between 4.128 and 4.226 GeV, corresponding to an integrated luminosity of 7.

Binding Properties of the General Odorant-Binding Protein GOBP2 to Herbicides and Insecticides in .

We previously reported that the general odorant-binding protein GOBP2 enhances chlorpyrifos tolerance in by perceiving the herbicides. However, the direct interaction between GOBP2 and pesticides remains unknown. Herein, we verified the effect of the direct binding of GOBP2 to pesticides on the herbicide-induced insecticide tolerance in .

Trends in the Burden of Epilepsy in China from 1990 to 2021 and Its Forecast until 2044: Based on the 2021 Global Burden of Disease Study.

Background: Epilepsy is one of the most prevalent neurological disorders, but no updated analysis of its burden in China.

Aims: This study provides the most up-to-date, comprehensive analysis of temporal trends and predicts future trends of idiopathic epilepsy in China.

Design: Secondary analysis based on the Global Burden of Disease (GBD).

tRNA selectivity during ribosome-associated quality control regulates the critical sterility-inducing temperature in two-line hybrid rice.

The two-line hybrid rice system, a cutting-edge hybrid rice breeding technology, has greatly boosted global food security. In thermo-sensitive genic male sterile (TGMS) lines, the critical sterility-inducing temperature (CSIT; the temperature at which TGMS lines change from male fertile to complete male sterile) acts as a key threshold. We recently uncovered that (), a sterile locus presenting in over 95% of TGMS lines, leads to the overaccumulation of 2',3'-cyclic phosphate (cP)-ΔCCA-tRNAs and a deficiency of mature tRNAs, which underlies the molecular mechanism of -mediated TGMS.

Diagnostic utility of lymphocyte enhancer factor 1 in aggressive B-cell lymphoma with MYC rearrangement.

Objectives: We sought to investigate the diagnostic value of lymphocyte enhancer factor 1 (LEF1) expression in aggressive B-cell lymphomas (BCL) with MYC gene rearrangement (MYC-R).

Methods: Sixty-seven cases of BCL were studied and included Burkitt lymphoma (BL) (23 cases); diffuse large B-cell lymphoma (DLBCL), not otherwise specified (NOS) with MYC-R (13 cases); and DLBCL/high-grade B-cell lymphoma with MYC, BCL2, and/or BCL6 rearrangements (double-hit [DH] or triple-hit [TH], 17 cases). Random DLBCL-NOS (14 cases) without MYC-R was recruited as a control group.

Impact of Snow on Underground Smoldering Wildfire in Arctic-Boreal Peatlands.

Overwintering peat fires are re-emerging in snow-covered Arctic-boreal regions, releasing unprecedented levels of carbon into the atmosphere and exacerbating climate change. Despite the critical role of fire-snow interactions in these processes, our understanding of them remains limited. Herein, we conducted small-scale outdoor experiments (20 × 20 × 20 cm) at subzero temperatures (-5 ± 5 °C) to investigate the impact of natural snowfall and accumulated snow layers (up to 20 cm thick) on shallow smoldering peat fires.

Intravenous thrombolysis prevents neurological deterioration in patients with acute pontine infarction.

Objectives: Neurological deterioration (ND) is common after acute isolated pontine infarction, and no evidence-based treatment is available to prevent this. We determined whether intravenous thrombolysis (IVT) with tissue plasminogen activator soon after pontine infarction prevents ND.

Methods: We retrospectively enrolled consecutive patients admitted to our hospital within 4.

Anti-poisoning of CO and carbonyl species over Pd catalysts during the electrooxidation of ethylene glycol to glycolic acid at elevated current density.

The electrocatalytic oxidation of ethylene glycol (EG) to produce valuable glycolic acid (GLYA) is a promising strategy to tackle EG overcapacity. Despite the good selectivity of Pd for EG oxidation, its performance is constrained by limited mass activity and toxicity of intermediates like CO or CO-analogues. This study reports the alloying of Pd with Ni and Mo metals to enhance the activity and durability of EG oxidation in alkaline media.

Targeted anchoring of Cu sites in imine-based covalent organic frameworks as catalytic centers for efficient Li-CO batteries.

Lithium-carbon dioxide (Li-CO) batteries have attracted much attention due to their high theoretical energy density and reversible CO reduction/evolution process. However, the wide bandgap insulating discharge product LiCO is difficult to decompose, leading to large polarization or even death of the battery, thus seriously hindering the practical application of Li-CO batteries. The properties of covalent organic framework (COF) materials, which can support the construction of multiphase catalytic systems, have great potential in the fields of CO enrichment and electrocatalytic reduction.

A New Nanocomposite for Inducing Demineralized Dentin Remineralization.

Objective: This study aimed to investigate a method for promoting the remineralization of demineralized dentin collagen fibers, with the objective of enhancing the bonding strength and durability of dentin resin while reducing the incidence of secondary caries.

Methods: A mineralized solution, PAMAM-COOH/ACMP-MDP ethanol solution, was prepared, consisting of the dendritic organic macromolecule PAMAM-COOH, magnesium ions, and methacryloyloxydecyl dihydrogen phosphate (MDP). We examined its storage stability.

Diagnostic efficacy of CEUS TI-RADS classification for benign and malignant thyroid nodules.

Objective: This study aims to evaluate the diagnostic efficacy of a novel system called contrasted enhanced ultrasound thyroid imaging reporting and data system (CEUS TI-RADS) for benign and malignant thyroid nodules. We also seek to assess inter-observer agreement.

Methods: The study recruited 433 patients who underwent thyroid ultrasound (US) and CEUS between January 2019 and June 2023 at Affiliated Hospital of Guangdong Medical University.

DOCK1/ELMO1/Rac1 Signaling is Essential for Vitreous-Induced Migration and Contraction of ARPE19 Cells.

To test the effects of dedicator of cytokinesis protein 1 (DOCK1) with its binding partner engulfment and cell motility protein 1 (ELMO1)-Rac1 axis on the vitreous-induced biological functions of retinal pigment epithelial (RPE) cells. Rac1 activity in RPE cells after vitreous stimulation was detected via a pull-down assay. The related protein expression levels were examined via western blot analysis.

Sapphire-Based Optrode for Low Noise Neural Recording and Optogenetic Manipulation.

Electrophysiological recording of neurons in deep brain regions using optogenetic stimulation is a powerful method for understanding and regulating the role of complex neural activity in biological behavior and cognitive function. Optogenetic techniques have significantly advanced neuroscience research by enabling the optical manipulation of neural activities. Because of the significance of the technique, constant advancements in implantable optrodes that integrate optical stimulation with low-noise, large-scale electrophysiological recording are in demand to improve the spatiotemporal resolution for various experimental designs and future clinical applications.

Unifying Electrochemically-Driven Multistep Phase Transformations of Rutile TiO to Rocksalt Nanograins for Reversible Li and Na Storage.

Rutile titanium dioxide (TiO(R)) lacks octahedral vacancies, which is not suitable for Li and Na intercalation via reversible two-phase transformations, but it displays promising electrochemical properties. The origins of these electrochemical performances remain largely unclear. Herein, the Li and Na storage mechanisms of TiO(R) with grain sizes ranging from 10 to 100 nm are systematically investigated.

Harnessing crRNA Transformer for Facile and Specific Nucleic Acid Detection.

CRISPR/Cas systems have emerged as promising tools for nucleic acid detection. However, their practical applications have been limited by poor specificity and the need for additional preprocessing steps. Inspired by the concept of transformers, we found that changing the forms of crRNA with spatial arrangement may endow CRISPR/Cas with an enhanced performance for nucleic acid detection.

Performance evaluation and application of second-generation environmentally-friendly composite dust suppressant in dust control.

This study compares the performance of two generations of environmentally friendly composite dust suppressants, derived from plant straw, with two commercial suppressants, water, and dust-proof netting. The aim is to address construction-related dust pollution while minimizing environmental impact. Through wind erosion resistance tests under simulated high-wind conditions, the second-generation suppressant at 2 L/m concentration is found to decrease the soil mass loss, outperforming others in efficiency.

Multiphoton imaging-based quantifiable collagen signatures for predicting outcomes in patients with pancreatic ductal adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) presents a clinical challenge due to its poor prognosis and high mortality rate. Here, we aimed to enhance the prognostic prediction of patients with PDAC by studying collagen features in tumor microenvironment using multiphoton microscopy (MPM) combining with image processing technique. We identified eight distinct tumor-associated collagen signatures (TACS1-8) from multiphoton images of PDAC tissues and developed an optical biomarker, TACS-score, based on the TACS1-8 using ridge regression analysis.

Multi-object coaxial imaging with an Airy beam array.

Multi-object imaging can obtain more comprehensive information to analyze the surrounding environment better and is widely used in many fields. While most multi-object imaging methods require objects not to be coaxial, which must ensure that each object is within the line-of-sight (LOS) of beam progression. In this paper, we present an approach for imaging multiple coaxial objects utilizing an Airy beam array, which can see hidden objects and is conducive to expanding the range of information perception.

Improvements in moderate-to-severe hidradenitis suppurativa with upadacitinib: Results from a phase 2, randomized, placebo-controlled study.

Background: Hidradenitis suppurativa is a disabling inflammatory skin disease.

Objective: To investigate the efficacy and safety of upadacitinib, a selective Janus kinase inhibitor.

Methods: In this phase 2, randomized, placebo-controlled, double-blind clinical trial (NCT04430855), adults with moderate-to-severe hidradenitis suppurativa were randomized 2:1 to once-daily upadacitinib 30 mg or placebo.

Interplay between gut microbial communities and metabolites modulates pan-cancer immunotherapy responses.

Immune checkpoint blockade (ICB) therapy has revolutionized cancer treatment but remains effective in only a subset of patients. Emerging evidence suggests that the gut microbiome and its metabolites critically influence ICB efficacy. In this study, we performed a multi-omics analysis of fecal microbiomes and metabolomes from 165 patients undergoing anti-programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) therapy, identifying microbial and metabolic entities associated with treatment response.