3D-Printed Prosthesis with an Articular Interface for Anatomical Acetabular Reconstruction After Type I + II (+ III) Internal Hemipelvectomy: Clinical Outcomes and Finite Element Analysis.

Background: Pelvic reconstruction after type I + II (or type I + II + III) internal hemipelvectomy with extensive ilium removal is a great challenge. In an attempt to anatomically reconstruct the hip rotation center (HRC) and achieve a low mechanical failure rate, a custom-made, 3D-printed prosthesis with a porous articular interface was developed. The aim of this study was to investigate the clinical outcomes of patients treated with this prosthesis.

Nondestructive detection of pungent and numbing compounds in spicy hotpot seasoning with hyperspectral imaging and machine learning.

The levels of capsaicin (CAP) and hydroxy-α-sanshool (α-SOH) are crucial for evaluating the spiciness and numbing sensation in spicy hotpot seasoning. Although liquid chromatography can accurately measure these compounds, the method is invasive. This study aimed to utilize hyperspectral imaging (HSI) combined with machine learning for the nondestructive detection of CAP and α-SOH in hotpot seasoning.

Diversity and Distribution of Fungi in the Marine Sediments of Zhanjiang Bay, China.

Fungi are one of the major components of the eukaryotic microbial community in marine ecosystems, playing a significant role in organic matter cycling and food web dynamics. However, the diversity and roles of fungi in marine sediments remain poorly documented. To elucidate the diversity and spatial distribution of fungal communities in the marine sediments of an estuary-coast continuum across three distinct salinity regions in Zhanjiang Bay, China, the variations in fungal diversity, abundance, community structure, and distribution in the sediments were investigated through the application of high-throughput amplicon sequencing using the internal transcribed spacer (ITS) primers.

Improving the Anti-Tumor Effect of Indoleamine 2,3-Dioxygenase Inhibitor CY1-4 by CY1-4 Nano-Skeleton Drug Delivery System.

CY1-4, 9-nitropyridine [2',3':4,5] pyrimido [1,2-α] indole -5,11- dione, is an indoleamine 2,3-dioxygenase (IDO) inhibitor and a poorly water-soluble substance. It is very important to increase the solubility of CY1-4 to improve its bioavailability and therapeutic effect. In this study, the mesoporous silica nano-skeleton carrier material Sylysia was selected as the carrier to load CY1-4, and then the CY1-4 nano-skeleton drug delivery system (MSNM@CY1-4) was prepared by coating the hydrophilic polymer material Hydroxypropyl methylcellulose (HPMC) and the lipid material Distearoylphosphatidyl-ethanolamine-poly(ethylene glycol) (DSPE-PEG) to improve the anti-tumor effect of CY1-4.

Enhanced Eicosapentaenoic Acid Production via Synthetic Biological Strategy in .

The rational dietary ratio of docosahexaenoic acid (DHA) to eicosapentaenoic acid (EPA) can exert neurotrophic and cardiotrophic effects on the human body. The marine microalga produces EPA yet no DHA, and thus, it is considered an ideal EPA-only model to pursue a rational DHA/EPA ratio. In this study, synthetic biological strategy was applied to improve EPA production in .

The Effect of Phosphorus Concentration on the Co-Production of Fucoxanthin and Fatty Acids in .

The production of fucoxanthin and fatty acids in has been examined, but the role of elements like phosphorus in their mutualistic interactions is not well understood. To fill this gap, our study utilized potassium dihydrogen phosphate (KHPO) as a source of phosphorus to examine its impact on the synthesis of fucoxanthin and fatty acids in . Our findings revealed that at a phosphorus concentration of 10 mg L, the cell density (9.

Analysis and Testing of a Flyable Micro Flapping-Wing Rotor with a Highly Efficient Elastic Mechanism.

A Flapping-Wing Rotor (FWR) is a novel bio-inspired micro aerial vehicle configuration, featuring unique wing motions which combine active flapping and passive rotation for high lift production. Power efficiency in flight has recently emerged as a critical factor in FWR development. The current study investigates an elastic flapping mechanism to improve FWRs' power efficiency by incorporating springs into the system.

3D-Printed Hydrogel Scaffolds Loaded with Flavanone@ZIF-8 Nanoparticles for Promoting Bacteria-Infected Wound Healing.

Bacterial-infected skin wounds caused by trauma remain a significant challenge in modern medicine. Clinically, there is a growing demand for wound dressings with exceptional antibacterial activity and robust regenerative properties. To address the need, this study proposes a novel multifunctional dressing designed to combine efficient gas exchange, effective microbial barriers, and precise drug delivery capabilities, thereby promoting cell proliferation and accelerating wound healing.

Preparation of Chitosan Oleogel from Capillary Suspension and Its Application in Pork Meatballs.

In the oil dispersion of chitosan, the formation of a capillary bridge was triggered by adding a small amount of water to obtain an oleogel. With this method, the types of liquid oil and the ratio of oil/chitosan/water were explored to achieve an optimal oleogel. MCT performed best, followed by soybean oil, which was chosen for its edibility and cost.

Mechanisms of Low Temperature Thickening of Different Materials for Deepwater Water-Based Drilling Fluids.

During deepwater drilling, the low mudline temperatures and narrow safe density window pose serious challenges to the safe and efficient performance of deepwater water-based drilling fluids. Low temperatures can lead to physical and chemical changes in the components of water-based drilling fluids and the behavior of low temperature gelation. As a coarse dispersion system, water-based drilling fluid has a complex composition of dispersed phase and dispersing medium.

Rheological Properties of Weak Gel System Cross-Linked from Chromium Acetate and Polyacrylamide and Its Application in Enhanced Oil Recovery After Polymer Flooding for Heterogeneous Reservoir.

Long-term polymer flooding exacerbates reservoir heterogeneity, intensifying intra- and inter-layer conflicts, which makes it difficult to recover the remaining oil. Therefore, further improvement in oil recovery after polymer flooding is essential. In this study, a weak gel system was successfully synthesized, and possesses a distinct network structure that becomes more compact as the concentration of partially hydrolyzed polyacrylamide increases.

Synthesis, anti-oomycete and anti-fungal activities of novel paeonol ester derivatives containing a schiff base.

To discover biorational natural product-based pesticides, a series of paeonol ester derivatives containing a Schiff base (, , , and ) were prepared, and their structures were well characterised by H NMR and HRMS. Furthermore, bioactivities of these compounds as anti-oomycete and anti-fungal agents against two serious agricultural diseases, and we assessed. Amongst evaluated compounds, 1) Compounds and displayed good anti-oomycete against , with EC values of 116.

[Effects of different tillage measures on soil organic carbon in dryland wheat fields on the Loess Plateau, Northwest China based on meta-analysis].

To evaluate the effects of tillage measure on soil organic carbon (SOC) and influence degree of various factors on relative change rate of SOC at regional scale, we conducted a meta-analysis to investigate the impacts of tillage measures (CK, traditional deep tillage without straw return; NTS, no tillage with straw return; NT, no tillage without straw return; TS, traditional tillage with straw return; SS, subsoiling tillage) on SOC content and influence factors (climate conditions, soil types, cultivation types, and initial soil physicochemical properties) on relative change rate of SOC in dryland wheat fields on the Loess Plateau, based on literatures published during 2000-2023. Results indicated that NT, NTS, SS and TS performed varies positive effect on SOC content in 0-20 cm soil layer compared with CK. In addition, greater enhancement of SOC were obtained in conditions of loessal soil, mid-temperate zone, average annual temperature of ≤10 ℃ and average annual rainfall of ≤500 mm.

The Prevalence of Low-level Viraemia and Its Association with Virological Failure in People Living With HIV: A Systematic Review and Meta-Analysis.

Low-level viraemia (LLV) following antiretroviral therapy (ART) in people living with HIV (PLWH) has not received sufficient attention. To the determine the prevalence of LLV and its association with virological failure (VF), we systematically reviewed evidence-based interventions for PLWH. We searched PubMed, the Cochrane Library, Embase, and Web of Science from inception to 22 May 2024.

The relationship between inflammatory factors and heart failure: evidence based on bidirectional Mendelian randomization analysis.

Objective: Inflammatory factors play a crucial role in the onset and progression of heart failure. To further explore the causal relationship between inflammatory factors and heart failure, we employed bidirectional Mendelian randomization analysis to investigate the causal links between 91 inflammatory cytokines and heart failure.

Methods: We conducted our study using the bidirectional Mendelian randomization approach.

Corrigendum to "Tongxinluo promotes axonal plasticity and functional recovery after stroke".

[This corrects the article DOI: 10.1515/tnsci-2020-0127.].

Inflammation and nutritional status in relation to mortality risk from cardio-cerebrovascular events: evidence from NHANES.

Objective: Inflammation and nutritional status are closely associated with the mortality risk of survivors of cardio-cerebrovascular events. This study aims to evaluate the relationship between inflammation and nutritional indices and mortality among, identifying the most predictive indices.

Methods: This study included cohort data of the survivors of major adverse cardiovascular and cerebrovascular events (MACCE) from the National Health and Nutrition Examination Survey (NHANES) in 1999-2010.

Influence of inhaled nitric oxide on bronchopulmonary dysplasia in preterm infants with PPHN or HRF at birth: a propensity score matched study.

Background: Bronchopulmonary Dysplasia (BPD) is a chronic lung disease affecting preterm infants, with limited prevention and treatment options. Inhaled Nitric Oxide (iNO) is sometimes used to treat Persistent Pulmonary Hypertension of the Newborn (PPHN) and Hypoxemic Respiratory Failure (HRF), and its impact on BPD development remains debated.

Objective: To assess whether iNO-related factors are potential contributors to the development of BPD Grade Ⅱ-Ⅲ in very premature infants (VPI) diagnosed with PPHN or HRF at birth using Propensity Score Matching (PSM).

Hyperbaric Oxygen Protects Acute Lung Injury Secondary to Venom Poisoning by Regulating Th17/Treg Balance.

Background: To explore the mechanism of hyperbaric oxygen (HBO) intervention on acute lung injury secondary to snake venom poisoning and provide more toxicological and clinical evidence for venom poisoning.

Methods: Male Kunming mice (n = 96) were randomly divided into four groups: the control group which was not given any interventional treatments, venom group in which each mouse was injected with venom (1 mg/kg) through the tail vein, antivenom group in which each mouse was injected with anti- venom immediately after the model was successfully established, and HBO+antivenom group in which each mouse was given HBO treatment at 1 h, 5 h, 11 h and 23 h following the injection of antivenom. Lung tissues of mice were obtained and processed for the detection of the lung coefficient, the levels of inflammatory factors such as interleukin (IL)-6, IL-10 and IL-17, and the protein expression of retinoic acid receptor (RAR)-related orphan receptor gamma (RORγt) and forkhead box P3 (FOXP3).

Epidemiological and clinical characteristics of ammonia-producing microorganisms in the lungs of patients with severe pneumonia: a multicentre cohort study.

Background: Ureaplasma urealyticum, Ureaplasma parvum, and Mycoplasma hominis were widely known as ammonia-producing microorganisms and can cause hyperammonemia, leading to cerebral edema and altered consciousness, which represent serious complications in lung transplant recipients. However, there is limited knowledge on the epidemiology and outcomes of infections caused by U. urealyticum, U.

Surgical treatment of Gorham-Stout disease combined with scoliosis: a case report and literature review.

Background: Gorham-Stout disease (GSD) is a rare disease characterized by osteolysis and lymphatic malformations. GSD involving the spine is exceptionally rare and lacks a standard cure. The aim of this article was to report a case of GSD with scoliosis treated via corrective surgery and medication.

Upregulated YTHDC1 mediates trophoblastic dysfunction inducing preterm birth in ART conceptions through enhanced RPL37 translation.

Assisted reproductive technology (ART) pregnancies present a higher risk of singleton preterm birth than natural pregnancies, but the underlying molecular mechanism remains largely unknown. RNA mA modification is a key epigenetic mechanism regulating cellular function, but the role of mA modification, especially its "reader" YTHDC1, in preterm delivery remains undefined. To delineate the role and epigenetic mechanism of mA modification in ART preterm delivery, the effects of YTHDC1 on trophoblastic function were evaluated by CCK-8, EdU, Transwell, and flow cytometry analyses post its overexpression or knockdown.