Probiotics Antimicrob Proteins
January 2025
Over the past 3 years, there has been a growing interest in clinical research regarding the potential involvement of intestinal flora in thyroid cancer (TC). This review delves into the intricate connection between intestinal flora and TC, focusing on the particular intestinal flora that is directly linked to the disease and identifying which may be able to predict potential microbial markers of TC. In order to shed light on the inflammatory pathways connected to the onset of TC, we investigated the impact of intestinal flora on immune modulation and the connection between chronic inflammation when investigating the role of intestinal flora in the pathogenesis of TC.
View Article and Find Full Text PDFSenescence and loss of cochlear hair cells is an important pathologic basis of age-related hearing loss. Lipid droplet accumulation has previously been shown to play an important role in neurodegeneration; however, its role in age-related hearing loss has not yet been investigated. LXRβ/ABCA1 is a key pathway that regulates lipid metabolism, while its dysfunction can cause abnormal accumulation of lipid droplets in neurons, leading to neurodegeneration.
View Article and Find Full Text PDFSince 2010, the Lineage 1 (NADC30-like) and Lineage 3 (QYYZ-like) strains of PRRSV-2 have become widespread in China, undergoing recombination and resulting in varying virulent and immune-evading mutants that have severely impacted the pig farming industry. In this study, we isolated one NADC30-like strain (GXHX20211106) and one QYYZ-like strain (GXGG202007) from pig serum samples collected in southern China. Comparative genomic analysis revealed that GXHX20211106 shares 90 % identity with NADC30, while GXGG202007 shows 91.
View Article and Find Full Text PDFBackground: To compare the effects of ultrasound-guided tumescent local anesthesia (TLA) and epidural anesthesia in great saphenous vein stripping and to explore the feasibility of using TLA in this procedure.
Methods: This study included 144 patients diagnosed with varicose veins of the great saphenous vein who required surgical treatment and were admitted to the Second People's Hospital affiliated with Fujian University of Traditional Chinese Medicine from March 2020 to November 2023. Patients were divided into 2 groups based on the anesthesia method used, including the observation group (TLA) and the control group (epidural anesthesia), with 72 patients in each group.
Accurately predicting the efficiency of surfactant-enhanced recovery of non-aqueous phase liquid (NAPL) using non-ionic surfactants requires a precise estimation of the kinetics of rate-limited solubilization under the effect of bulk partition. This study investigated the kinetics of surfactant partition from aqueous phase into liquid NAPL and its subsequent impact on the solubilization kinetics of dodecane. For all surfactants examined, the solubilization of dodecane by anionic rhamnolipid (RL) and SDBS, presenting NAPL-water interface adsorption loss only, closely followed the first-order mass transfer model under the assumption of constant solubility.
View Article and Find Full Text PDFThe fate of soil organic carbon lost from eroding coastal wetlands is of great importance. A large fraction of this carbon upon erosion is released as dissolved organic carbon (DOC) and inorganic carbon (DIC) into adjacent water bodies while the remainder is lost to atmosphere as CO. In this study, we investigate the seasonal concentrations and transport of DOC in Barataria Basin, Louisiana, USA, which borders the northern Gulf of Mexico (nGOM).
View Article and Find Full Text PDFPorcine epidemic diarrhea virus (PEDV) is a highly contagious virus that causes acute infectious disease in swine, with mortality rates in piglets reaching up to 100%. In recent years, PEDV has led to significant economic losses in China's pig industry. As there is no specific treatment for PEDV, vaccination remains a key strategy for its prevention and control.
View Article and Find Full Text PDFROR1 has been identified as a pseudokinase, functioning as an allosteric regulator in tumor progression. Aberrant overexpression of ROR1 has been observed in various malignancies, highlighting its potential as therapeutic target for cancer therapy. Modulation of ROR1 by proteolysis targeting chimera degrader instead of traditional inhibitor could offer great efficiency in blocking its kinase-independent regulatory function.
View Article and Find Full Text PDFDeoxyribonucleic acid (DNA) serves as a repository of genetic information in cells and is a critical molecular target for various antibiotics and anticancer drugs. A profound understanding of small molecule interaction with DNA is crucial for the rational design of DNA-targeted therapies. While the molecular mechanics/Poisson-Boltzmann surface area (MM/PBSA) and molecular mechanics/generalized Born surface area (MM/GBSA) approaches have been well established for predicting protein-ligand binding, their application to DNA-ligand interactions has been less explored.
View Article and Find Full Text PDFIn this work, the regulation of liquid self-transport is achieved through architectural and thermal coupling, transitioning from free surfaces to open channels. Hierarchical structures inspired by the skin of a Texas horned lizard are designed, with the primary structure of wedged grooves and the secondary structure of capillary crura. This design enables advantages including long-distance self-transport, liquid storage and active reflux management on free surfaces, directional transportation, synthesis and detection of reagents in confined spaces, as well as controllable motion and enhanced heat dissipation in open channels.
View Article and Find Full Text PDFPlants adjust the size of their stomatal openings to balance CO intake and water loss. Carbonic anhydrases (CAs) facilitate the conversion between CO and HCO , and the OsβCA1 mutant in rice (Oryza sativa) shows similar traits in carbon fixation and stomatal response to CO as the dual βCA mutants in Arabidopsis thaliana. However, the exact role of OsβCA1 in these processes was unclear.
View Article and Find Full Text PDFUnlabelled: Sepsis-induced acute liver injury (SALI) is a prevalent and life-threatening complication associated with sepsis. The gut microbiota plays a crucial role in the maintenance of health and the development of diseases. The impact of physical exercise on gut microbiota modulation has been well-documented.
View Article and Find Full Text PDFNeuromorphic vision sensors capable of multispectral perception and efficient recognition are highly desirable for bioretina emulation, but their realization is challenging. Here, we present a cocrystal strategy for preparing an organic nanowire retinamorphic vision sensor with UV-vis-NIR perception and fast recognition. By leveraging molecular-scale donor-acceptor interpenetration and charge-transfer interfaces, the cocrystal nanowire device exhibits ultrawide photoperception ranging from 350 to 1050 nm, fast photoresponse of 150 ms, high specific detectivity of 8.
View Article and Find Full Text PDFIt is always important and fascinating to explore new organic emitters that exploit unconventional pathways to unveil their emission with unique properties, such as thermally activated delayed fluorescence (TADF). In this study, we report that the rarely explored sulfur lone pair (n) is a promising alternative, where the correlated π* → n emission can be used to attain strong TADF and thus practical OLEDs. The designed strategy incorporates several key concepts (Figure 1a), in which the persulfide aromatic spirocycle enhances spin-orbit coupling, thereby increasing the intersystem crossing rate.
View Article and Find Full Text PDFObjective: This study aims to identify potential lipid biomarkers and metabolic pathways associated with oral cancer (OC). Then to establish and evaluate disease classification models capable of distinguishing OC patients from healthy controls.
Methods: A total of 41 OC patients and 41 controls were recruited from a hospital in Southeast China to examine the serum lipidomics by Ultra-high Performance Liquid Chromatography Q Exactive Mass Spectrometry (UHPLC-QE-MS).
All-perovskite tandem solar cells (APTSCs) offer the potential to surpass the Shockley-Queisser limit of single-junction solar cells at low cost. However, high-performance APTSCs contain unstable methylammonium (MA) cation in the tin-lead (Sn-Pb) narrow bandgap subcells. Currently, MA-free Sn-Pb perovskite solar cells (PSCs) show lower performance compared with their MA-containing counterparts.
View Article and Find Full Text PDFOligodendrocyte precursor cells (OPCs) shape brain function through many non-canonical regulatory mechanisms beyond myelination. Here we show that OPCs form contacts with their processes on neuronal somata in a neuronal activity-dependent manner. These contacts facilitate exocytosis of neuronal lysosomes.
View Article and Find Full Text PDFEthnopharmacological Relevance: Zuo Gui Wan (ZGW) is a well-known traditional Chinese medicine decoction used for approximately 400 years to treat age-related degenerative conditions, including cognitive impairment in older adults, osteoporosis, and general aging. However, the mechanism of action for ZGW remains unclear.
Aims Of The Study: This study aims to investigate the efficacy of ZGW in improving cognitive function in Alzheimer's disease (AD) animal models and to explore the underlying mechanisms, presenting a novel perspective in the field.
Objective: The construction of a gastric-tube-substitute esophagus is a common method for digestive tract reconstruction after esophagectomy. However, the incidence of postoperative anastomotic leakage remains high. This study aims to compare the effectiveness of 2 gastric tube fabrication methods-cis-cutting and retro-cutting-in reducing postoperative anastomotic leakage.
View Article and Find Full Text PDFStudy Objective: Difficult airway management is a significant challenge in clinical anesthesia, critical care, and emergency medicine. Inadequate management can lead to severe complications including organ damage and death. This study assessed the variability in difficult airway management across China and focused on how patient and operator factors influenced outcomes in operating rooms.
View Article and Find Full Text PDFEndometrial cancer (UCEC) is the most prevalent gynecological malignancy in high-income countries, and its incidence is rising globally. Although early-stage UCEC can be treated with surgery, advanced cases have a poor prognosis, highlighting the need for effective molecular biomarkers to improve diagnosis and prognosis. In this study, we analyzed mRNA and miRNA sequencing data from UCEC tissues and adjacent non-cancerous tissues from the TCGA database.
View Article and Find Full Text PDFBackground: Sarcopenia, sarcopenic obesity, and hypertension are all widespread public health problems in middle-aged and older populations, and their association is controversial. The purpose of this study is to analyze the relationship between obesity, sarcopenia, and sarcopenic obesity with hypertension in a middle-aged and older community population in China through a large-scale longitudinal design.
Methods: In this cohort study with 7 years of follow-up, the study population was drawn from participants in the China Health and Retirement Longitudinal Study (CHARLS) in 2011 and followed up in 2013, 2015, and 2018.
Next-generation real-time gas sensors are crucial for detecting multiple gases simultaneously with high sensitivity and selectivity. In this study, ternary metal sulfide (PbSnS)-incorporated metal oxide (SnO) heterostructures were synthesized via a one-step hydrothermal method. Characterizations such as X-ray diffraction, high-resolution transmission electron microscopy, and X-ray photoelectron spectroscopy confirmed the successful formation of PbSnS/SnO heterostructures.
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