Combined detection of monocyte distribution width and procalcitonin for diagnosing and prognosing neonatal sepsis.

Background: To assess the value of combined Monocyte Distribution Width (MDW) and Procalcitonin (PCT) detection in diagnosing and predicting neonatal sepsis outcomes.

Methods: This retrospective study, conducted from January 2022 to December 2023.A retrospective analysis of 39 neonatal sepsis and 30 non-infectious systemic inflammatory response syndrome (SIRS) cases was conducted.

[Protective effect of tumor necrosis factor receptor-associated factor 6 inhibitor C25-140 on acute kidney injury induced by diquat poisoning in mice].

Objective: To investigate the protective effect and mechanism of tumor necrosis factor receptor-associated factor 6 (TRAF6) inhibitor C25-140 on acute kidney injury (AKI) induced by acute diquat (DQ) poisoning in mice.

Methods: A total of 80 SPF grade healthy male C57BL/6 mice were randomly divided into the normal control group, DQ model group, C25-140 intervention group, and C25-140 control group, with 20 mice in each group. The DQ poisoning mouse model was established by using one-time intraperitoneal injection of 1 mL of 40 mg/kg DQ solution.

Regulation of Oil/Water Separation Using Pyridinium-Based Poly(ionic liquid)s with Prewetted Induced Responsive Transition.

The development of affordable, intelligent dual-separation technology is crucial for the treatment of oil-water mixtures. Pyridinium-based poly(ionic liquid)s (PILs), designed using molecular theory, exhibit unique switching wettability properties, making them ideal for use in both aqueous and oily environments. By prewetting the material's surface with water or oil, the targeted separation of these components becomes feasible.

A MACPF Protein OsCAD1 Balances Plant Growth and Immunity Through Regulating Salicylic Acid Homeostasis in Rice.

Unraveling the mechanisms behind plant growth and immunity contributes to effective crop improvement. Membrane attack complex/perforin (MACPF) domain proteins play vital roles in innate and adaptive immunity in vertebrates; however, their molecular functions in plants remain largely unexplored. Here, we isolated and characterized a rice mutant, Oryza sativa constitutively activated cell death 1 (oscad1), which exhibited a lesion mimic phenotype and growth inhibition with increased cell death, elevated ROS accumulation, and enhanced resistance to bacterial blight Xanthomonas oryzae pv.

The mitochondrial function of peripheral blood cells in cognitive frailty patients.

Background: Cognitive frailty (), characterized by the coexistence of physical frailty and cognitive impairment, is linked to increased morbidity and mortality in older adults. While has been linked to multiple physiological and lifestyle factors, the underlying biological mechanisms remain poorly understood. This study investigated the risk factors for and explored the relationship between mitochondrial function and in hospitalized patients.

[Sulforaphane alleviates acute liver injury induced by diquat in mice by activating Keap1/Nrf2 signaling pathway].

Objective: To investigate the protective effect and possible mechanism of sulforaphane (SFN) on acute liver injury in mice induced by diquat (DQ) poisoning.

Methods: Forty-eight male C57BL/6 mice were divided into Control group, DQ model group (DQ group), SFN intervention group (DQ+SFN group), and SFN control group (SFN group) using a random number table method, with 12 mice in each group. Acute liver injury mice model was established by one-time intraperitoneal injection of 1 mL of 40 mg/kg DQ solution at once.

Risk Factor Analysis and Prediction of Para-Aortic Lymph Node Metastases in Locally Advanced Cervical Cancer.

Background And Purpose: The indications of prophylactic extended-field radiotherapy (EFRT) remain uncertain. This study aims to identify the risk factors for para-aortic lymph node (PALN) metastases in locally advanced cervical cancer (LACC) and determine which part of patients may benefit from prophylactic EFRT.

Materials And Methods: Between January 2015 and July 2023, a single-center retrospective analysis was performed on patients with stages IB3 and IIA2-IVA cervical cancer.

Latent Solvent-Induced Inorganic-Rich Interfacial Chemistry to Achieve Stable Potassium-Ion Batteries in Low-Concentration Electrolyte.

Low-concentration electrolytes (LCEs) have attracted great attention due to their cost effectiveness and low viscosity, but suffer undesired organic-rich interfacial chemistry and poor oxidative stability. Herein, a unique latent solvent, 1,2-dibutoxyethane (DBE), is proposed to manipulate the anion-reinforced solvation sheath and construct a robust inorganic-rich interface in a 0.5 M electrolyte.

Effect of blood pressure variability on the outcomes of acute ischemic stroke patients undergoing intravenous thrombolysis.

Background: There is limited research on the relationship between blood pressure variability (BPV) and outcomes among patients receiving intravenous thrombolysis (IVT) for acute ischemic stroke (AIS). This study aimed to investigate the effect of 24-h BPV on the outcome of patients with AIS treated with IVT.

Methods: A retrospective analysis was conducted on clinical data of patients with AIS who had undergone IVT treatment.

Surveillance and characteristics of vancomycin-resistant Enterococcus isolates in a Chinese tertiary hospital in Shenzhen, 2018 to 2024.

Objective: To investigate the prevalence and characteristics of vancomycin-resistant Enterococcus (VRE) isolates in a Chinese tertiary hospital in Shenzhen.

Methods: A hospital-based retrospective epidemiological survey of Enterococcus was conducted over a 6.5-y period, from January 2018 to June 2024.

"Bis-Clamp-Cavity Synergy", an Efficient Approach to Improve Guest Binding Properties of Macrocyclic Host and Its Application on Detection of Al and Arg in Living Cells.

Improving the selective and sensitive binding properties of macrocyclic hosts to target guests is always an interesting challenge. Herein, we introduce a novel "bis-clamp-cavity synergy" strategy to enhance the selectivity and binding sensitivity of pillararenes toward target guests. To achieve this goal, we designed and synthesized ,'-bis-hydroxynaphthoylhydrazone-functionalized conjugated pillar[5]arene (), in which bis-hydroxynaphthoylhydrazone plays the role of clamps, while the pillar[5]arene provides the macrocyclic cavity.

Integrative Gut Microbiota and Metabolomic Analyses Reveal the PANoptosis- and Ferroptosis-Related Mechanisms of Chrysoeriol in Inhibiting Melanoma.

Chrysoeriol, a natural flavonoid, has shown potential in inhibiting melanoma. However, the detailed molecular mechanisms of its action still need to be clarified. In this study, chrysoeriol showed significant suppressive effects on melanoma progression in a mouse model.

Drug repurposing: An antidiabetic drug Ipragliflozin as Mycobacterium tuberculosis sirtuin-like protein inhibitor that synergizes with anti-tuberculosis drug isoniazid.

The surge of drug-resistant Mycobacterium tuberculosis (DR-TB) impedes the World Health Organization's efforts in ending TB and calls for new therapeutic formulations. M. tuberculosis sirtuin-like protein Rv1151c is a bifunctional enzyme with both deacetylation and desuccinylation activities, which plays an important role in M.

Polyketide Origin of the Indole Ring during the Biosynthesis of Indole Alkaloid Coprisidins.

Coprisidins, a new class of indole alkaloids, feature a 1,4-naphthoquinone moiety attached to C-3 of 2-oxindole. Heterologous expression of a type II polyketide synthase-containing gene cluster resulted in the generation of three coprisidins. Gene disruption and isotope feeding studies suggested that the 2-oxindole moieties of coprisidins originate from a tetracyclic aromatic polyketide through oxidative rearrangements.

Ursolic acid attenuates pseudo-allergic reactions via reducing MRGPRX2-mediated mast cell degranulation.

Mas-related G protein-coupled receptor X2 (MRGPRX2) is a newly identified receptor on mast cells that contribute to IgE-independent pseudo-allergy. Ursolic acid (UA), a pentacyclic triterpenoid, has been reported for its anti-allergy effects. However, the protective mechanism against pseudo-allergic reactions remains unclear.