Platelet-mimicking nanoparticles loaded with diallyl trisulfide for Mitigating Myocardial Ischemia-Reperfusion Injury in rats.

Hydrogen sulfide (HS) shows promise in treating myocardial ischemia-reperfusion injury (MIRI), but the challenge of controlled and sustained release hinders its clinical utility. In this study, we developed a platelet membrane-encapsulated mesoporous silica nanoparticle loaded with the HS donor diallyl trisulfide (PM-MSN-DATS). PM-MSN-DATS demonstrated optimal encapsulation efficiency and drug-loading content.

Influence of the Enterovirus 71 Vaccine and the COVID-19 Pandemic on Hand, Foot, and Mouth Disease in China Based on Counterfactual Models: Observational Study.

Background: Hand, foot, and mouth disease (HFMD) is a highly contagious viral illness. Understanding the long-term trends of HFMD incidence and its epidemic characteristics under the circumstances of the enterovirus 71 (EV71) vaccination program and the outbreak of COVID-19 is crucial for effective disease surveillance and control.

Objective: We aim to give an overview of the trends of HFMD over the past decades and evaluate the impact of the EV71 vaccination program and the COVID-19 pandemic on the epidemic trends of HFMD.

Structural-color meta-nanoprinting embedding multi-domain spatial light field information.

Recently, multifunctional metasurface has showcased its powerful functionality to integrate nanoprinting and holography, and display ultracompact meta-images in near- and far-field simultaneously. Herein, we propose a tri-channel metasurface which can further extend the meta-imaging ranges, with three independent images located at the interface, Fresnel and Fourier domains, respectively. Specifically, a structural-color nanoprinting image is decoded right at the interface of the metasurface, enabled by varying the dimensions of nanostructures; a Fresnel holographic image and another Fourier holographic image are present at the Fresnel and Fourier (far-field) domains, respectively, enabled by geometric phase.

Experimental retrieval of metaholographic images via evanescent wave using a single-layer nanostructure for encryption.

Metasurfaces have demonstrated significant potential in optical encryption and anti-counterfeiting due to their incredible capability of manipulating various light properties. However, previous metasurface-encryption methods did not sufficiently explore the spatial frequency aspect, particularly regarding evanescent waves. Here, we propose an encryption scheme by introducing evanescent waves into the encoding and decoding processes.

Four new species and a key to Australian species of the genus Diochus Erichson (Coleoptera: Staphylinidae, Staphylininae, Diochini).

The Australian species of the genus Diochus Erichson, 1839 (Coleoptera: Staphylinidae, Staphylininae, Diochini) are reviewed and four new species are described: Diochus basseti sp. nov. and D.

Taxonomy of the genus Diochus Erichson (Coleoptera: Staphylinidae, Staphylininae, Diochini) of Papua New Guinea, Vanuatu and Solomon Islands.

This paper presents taxonomic studies of the genus Diochus Erichson, 1839 (Coleoptera: Staphylinidae, Staphylininae, Diochini) from Papua New Guinea, Vanuatu and Solomon Islands. Three new species are described: Diochus elongatus Huang, Janák & Zhou, sp. nov.

Six new species and a key to 12 species of the genus Diochus Erichson (Coleoptera: Staphylinidae, Staphylininae, Diochini) from India, Nepal and Pakistan.

This paper presents taxonomic studies of the genus Diochus Erichson, 1839 (Coleoptera: Staphylinidae, Staphylininae, Diochini) of Bhutan, India, Nepal, Myanmar, Pakistan and Thailand. Six new species are described: Diochus cameroni Huang, Janák & Zhou, sp. nov.

Gr-1 blockade remodels the immunosuppressive microenvironment induced by incomplete microwave ablation of hepatocellular carcinoma.

Background: Ablation is one of the main methods for local treatment of hepatocellular carcinoma (HCC). Different from radiofrequency ablation (RFA), microwave ablation (MWA) is not limited by tissue conductivity, and can use multiple electrodes at the same time to improve ablation efficiency. In addition, MWA can form a larger ablation area, which makes it possible to completely ablate large HCC.

Tri-channel metasurface fusion of continuously varying gray levels for nanoprinting and holographic displays.

Metasurfaces are extensively utilized in nanoprinting and hologram fusion displays due to their superior wavefront shaping capabilities. However, the creation of continuously varying grayscale images based on conventional Malus's law necessitates the use of at least one polarizer for observation, which compromises the metasurface's integration. In this study, inspired by the Jacobi-Anger expansion, we propose a tri-channel metasurface to establish three independent information channels for simultaneous grayscale nanoprinting and polarization multiplexed holography.

Preparation of nanocellulose-silk fibroin stiff hydrogel and high absorbing-low expansion xerogel via polysaccharide-protein interactions.

Inspired by the unique environmental sensitivities of polysaccharides and proteins, nanocellulose (NC) and silk fibroin (SF) nanocomposite hydrogels with tailored network structures and mechanical properties were developed by varying induction methods and assembly sequences. In the optimal process, SF was first assembled along the NC template to create a unique nanobead-like structure under thermal induction, followed by crosslinking in an acetic acid coagulation bath to form a polysaccharide-protein nanocomposite hydrogel with high mechanical strength, with elastic modulus as of 62,330 G' in Pa at only 0.25 wt% NC and 1.

Preparation of carboxylated-silk nanofibers by the one-pot method of maleic acid hydrolysis.

In this study, a maleic acid (MA) hydrolysis one-pot method is proposed to prepare carboxylated silk nanofibers (MA-SNFs). The MA concentration, hydrolysis temperature, and processing time were optimized. Combined with high-pressure homogenization, MA-SNFs with a carboxyl content of 0.

Minimalist design of multifunctional metasurfaces for helicity multiplexed holography and nanoprinting.

Recently, polarization multiplexing has become a common strategy to enhance the information capacity of metasurfaces. Nevertheless, the intricate design of anisotropic nanostructures forming a polarization multiplexed metasurface poses a significant challenge, increasing the requirements for manufacturing processes and diminishing overall robustness. Herein, we present a minimalist metasurface comprised of only two kinds of nanostructures to achieve the integration of continuous-amplitude modulated nanoprinting and eight-step phase-only helicity-multiplexed holography.

Introducing Phosphate Ester into DAPhen by Propyl Enhanced the Selectivity for UO over Th.

A new type of phenanthroline carboxamide(DAPhen)-phosphate ester ligand (/) was synthesized for the selective separation of U(VI) over Th(IV). Liquid-liquid extraction experiments showed that the introduction of phosphate ester could increase the extraction ability of ligands for U(VI), especially , which showed high selectivity for the separation of U(VI) over Th(IV). The slope analysis indicated that could form 1:1 and 1:2 complexes with U(VI) and 1:1 complexes with Th(IV).

Photo-Amplified Plasma Membrane Rupture by Membrane-Anchoring NIR-II Small Molecule Design for Improved Cancer Photoimmunotherapy.

Immunotherapy is a promising cancer treatment method for eradicating tumor cells by enhancing the immune response. However, there are several major obstacles to conventional phototherapy-mediated immune responses, including inadequate immunogenicity and immunosuppressive environment. Here, we present a novel photoimmunotherapy modality-the development of membrane-anchoring small molecule inducing plasma membrane rupture (PMR) by NIR-II photo-stimulation, thus evoking cell necrotic death and enhancing antitumor immunotherapy.

KIF18B: an important role in signaling pathways and a potential resistant target in tumor development.

KIF18B is a key member of the kinesin-8 family, involved in regulating various physiological processes such as microtubule length, spindle assembly, and chromosome alignment. This article briefly introduces the structure and physiological functions of KIF18B, examines its role in malignant tumors, and the associated carcinogenic signaling pathways such as PI3K/AKT, Wnt/β-catenin, and mTOR pathways. Research indicates that the upregulation of KIF18B enhances tumor malignancy and resistance to radiotherapy and chemotherapy.

Electrically tunable planar liquid-crystal singlets for simultaneous spectrometry and imaging.

Conventional hyperspectral cameras cascade lenses and spectrometers to acquire the spectral datacube, which forms the fundamental framework for hyperspectral imaging. However, this cascading framework involves tradeoffs among spectral and imaging performances when the system is driven toward miniaturization. Here, we propose a spectral singlet lens that unifies optical imaging and computational spectrometry functions, enabling the creation of minimalist, miniaturized and high-performance hyperspectral cameras.

Characteristics, Influence, Prevention, and Control Measures of the Mpox Infodemic: Scoping Review of Infodemiology Studies.

Background: The mpox pandemic has caused widespread public concern around the world. The spread of misinformation through the internet and social media could lead to an infodemic that poses challenges to mpox control.

Objective: This review aims to summarize mpox-related infodemiology studies to determine the characteristics, influence, prevention, and control measures of the mpox infodemic and propose prospects for future research.

Endothelin 3/EDNRB signaling induces thermogenic differentiation of white adipose tissue.

Thermogenic adipose tissue, consisting of brown and beige fat, regulates nutrient utilization and energy metabolism. Human brown fat is relatively scarce and decreases with obesity and aging. Hence, inducing thermogenic differentiation of white fat offers an attractive way to enhance whole-body metabolic capacity.

Effects of 6-Week Weighted-Jump-Squat Training With and Without Eccentric Load Reduction on Explosive Performance.

Purpose: To compare the effects of 6-week barbell weighted-jump-squat (WJS) training with and without eccentric load reduction on explosive performance.

Methods: Twenty well-trained male athletes were randomly assigned to either an experimental group (n = 10) or a control group (n = 10). Participants completed 12 WJS training sessions (6 sets of 5 repetitions of barbell back squat at 30% of 1-repetition maximum [1RM]) twice a week over a 6-week period.

GJB2 Promotes HCC Progression by Activating Glycolysis Through Cytoplasmic Translocation and Generating a Suppressive Tumor Microenvironment Based on Single Cell RNA Sequencing.

Despite substantial breakthroughs in the treatment of hepatocellular carcinoma (HCC) in recent years, many patients are diagnosed in the middle or late stages, denying them the option for surgical excision. Therefore, it is of great importance to find effective therapeutic targets of HCC. In this study, it is found that Gap junction protein beta-2 (GJB2) is highly enriched in malignant cells based on single-cell RNA sequencing and higher expression of GJB2 indicates a worse prognosis.