utilizes L-arabinose to silence virulence gene expression for accelerated pathogen growth within the host.

Carbon source is an important nutrient for bacteria to sustain growth and often acts as a signal that modulates virulence expression. L-arabinose is produced by plants and plays an important role in regulating the global gene expression of bacteria. Previously, we have shown that L-arabinose induces a more severe systemic infection in -infected mice with normal microbiota, but does not affect the disease progression in mice with microbiota depleted by antibiotic treatment.

Within-host evolution of a transcriptional regulator contributes to the establishment of chronic Pseudomonas aeruginosa infection.

As an opportunistic pathogen, Pseudomonas aeruginosa can cause both acute and chronic infections that are notoriously difficult to treat. However, the mechanism underlying acute or chronic P. aeruginosa infection remains unclear.

EML4-ALK-Positive Ovarian Cancer With Intracranial Metastasis Responds to Lorlatinib: A Case Report and Literature Review.

We report a case showing that lorlatinib is effective in treating EML4-ALK-positive low-grade serous ovarian cancer (LGSO) with intracranial metastasis. This may be the first clinical evidence of LGSO benefit from ALK inhibitors, to provide evidence for the use of ALK inhibitors in more ovarian cancer patients with EML4-ALK fusion and promoting new ideas for the study of EML4-ALK targets in ovarian cancer.

Prevention and management of medical adhesive-related skin injuries in tumor patients with peripheral central venous catheters: a best practice implementation project.

Introduction: Peripheral central venous catheters are common vascular access devices used in patients with tumors. To prevent catheter shedding and displacement, it is essential to use medical adhesives to secure the catheters. Repeated adhesion and removal of medical adhesives can weaken the barrier function of the skin, leading to medical adhesive-related skin injuries (MARSI), which can increase the patients' pain and medical expenses.

Dietary L-arabinose-induced gut dysbiosis exacerbates infection outcome.

The gut microbiota is essential for providing colonization resistance against pathogens. Dietary sugars markedly shift the composition of the intestinal microbiota and alter host susceptibility to enteric infections. Here, we demonstrate the effect of L-arabinose on bacterial infection by using a mouse infection model with serovar Typhimurium (.

A new analytical model for bond strength between corroded steel strand and concrete.

Degradation of bond strength due to corrosion of steel strands is of great importance for serviceability of prestressed concrete structures. An analytical model is proposed to demonstrate the effect of corrosion of steel strand on reduction of bond strength. Corrosion expansion force generated by steel strand corrosion before and after corrosion cracking is firstly estimated.

Does frequent tea consumption provide any benefit to cognitive function in older adults? Evidence from a national survey from China in 2018.

Objectives: This present study aims to investigate the effect of tea consumption on cognitive function and examine possible psychosocial mechanisms in older adults.

Participants And Methods: The data of this study came from the 2018 wave of the Chinese Longitudinal Healthy Longevity Survey(CLHLS), and a total of 11,910 valid samples were included. We used ordinary least squares (OLS) to explore whether frequent tea consumption had significant effect on the cognitive function of older people.

Medical Evaluation Readiness Information Toolset (MERIT): Developing a Data-driven Decision Support Tool to Augment Complex Clinical Decisions.

Introduction: Medical readiness continues to be a significant concern for the military. DoD policy directs medical authorities to refer service members to the Disability Evaluation System (DES) when the course of further recovery is relatively predictable or within 1 year of diagnosis, whichever is sooner. The Medical Evaluation Readiness Information Toolset (MERIT) is an application that leverages artificial intelligence within a clinical decision support tool to provide clinicians with predictions of a service member's likelihood of referral to the DES for the top 24 medical conditions that result in separation from the service, which represent more than 90% of all referral cases to the DES since 2000.

ASIC1/RIP1 accelerates atherosclerosis via disrupting lipophagy.

Introduction: Atherosclerosis, a major contributor to cardiovascular disease, remains a significant health concern worldwide. While previous research has shown that acid-sensing ion channel 1 (ASIC1) impedes macrophage cholesterol efflux, its precise role in atherogenesis and the underlying mechanisms have remained elusive.

Objectives: This study aimed to investigate the role of ASIC1 in atherosclerosis and its underlying mechanisms.

Prognostic factor analysis and clinical significance of HER‑2‑positive breast cancers with negative lymph nodes and a tumor diameter ≤1 cm.

The 2021 National Comprehensive Cancer Network guidelines recommend that adjuvant chemotherapy combined with trastuzumab be considered for human epidermal growth factor receptor 2 (HER-2)-positive breast cancer patients with small tumors (tumor diameter ≤1 cm) and negative lymph nodes. Additionally, the prognostic factors and clinical significance of HER-2-positive breast cancer with negative lymph nodes and a tumor diameter ≤1 cm remain unclear. In the present study, the clinical data and prognostic factors of 87 patients with HER-2-positive breast cancer with negative lymph nodes and a tumor diameter ≤1 cm admitted to Guangdong Women and Children Hospital from January 2013 to December 2019 were retrospectively analyzed.

The metabolites of lactic acid bacteria: classification, biosynthesis and modulation of gut microbiota.

Lactic acid bacteria (LAB) are ubiquitous microorganisms that can colonize the intestine and participate in the physiological metabolism of the host. LAB can produce a variety of metabolites, including organic acids, bacteriocin, amino acids, exopolysaccharides and vitamins. These metabolites are the basis of LAB function and have a profound impact on host health.

Effectiveness of exercise interventions in the management of cancer-related fatigue: a systematic review of systematic reviews.

Background: Cancer-related fatigue is a widely prevalent global public health concern with serious consequences. Increasing evidence suggests the effectiveness of exercise intervention in treating cancer-related fatigue, but there is a lack of a summary of relevant literature on the same to help reach a clear consensus.

Objective: To summarize evidence regarding the efficacy of exercise interventions to reduce cancer fatigue, as determined in systematic reviews (SRs) and/or meta-analyses (MAs).

Nitrogen-doped carbonized polymer dots activated by alkalinity of arginine for multicolor multi-platform sensor.

Among carbon-based materials, carbon dots (CDs) are popular because of their stable optical properties and good biocompatibility. Their fluorescence properties often are tailored by size, surface modification, or heteroatom doping with multiple precursors. In this paper, the alkalinity of Arginine (Arg) acts as an activator to promote carbonation and increase luminescence efficiency.

Release of Pb adsorbed on graphene oxide surfaces under conditions of Shewanella putrefaciens metabolism.

In this study, Pb(II) was used as a target heavy metal pollutant, and the metabolism of Shewanella putrefaciens (S. putrefaciens) was applied to achieve reducing conditions to study the effect of microbial reduction on lead that was preadsorbed on graphene oxide (GO) surfaces. The results showed that GO was transformed to its reduced form (r-GO) by bacteria, and this process induced the release of Pb(II) adsorbed on the GO surfaces.

Clinical Study of Acupotomy for Knee Osteoarthritis Based on the Meridian-Sinew Theory: A Randomized Controlled Clinical Trial.

This study was performed to compare the effectiveness of acupotomy based on the meridian-sinew theory with acupotomy based on the anatomical theory in the treatment of knee osteoarthritis (KOA). A total of 124 patients with knee osteoarthritis were randomized into the meridian-sinew (MS) group (63 patients) and anatomy group (61 patients). In the MS group, acupotomy based on the meridian-sinew theory was performed.

LINC02381, a sponge of miR-21, weakens osteogenic differentiation of hUC-MSCs through KLF12-mediated Wnt4 transcriptional repression.

Introduction: Human umbilical cord blood-derived MSCs (hUC-MSCs) have the potential to differentiate into osteoblasts. This study investigated the function and potential mechanisms of a novel lncRNA LINC02381 in hUC-MSC osteogenic differentiation.

Materials And Methods: hUC-MSCs were maintained in osteogenic differentiation medium.

Synthesis and biological evaluation of novel 8- substituted sampangine derivatives as potent inhibitor of Zn-Aβ complex mediated toxicity, oxidative stress and inflammation.

A series of 8-substituted sampangine derivatives have been designed, synthesized and tested for their ability to inhibit cholinesterase and penetrate the blood-brain barrier. Their chelating ability toward Zn and other biologically relevant metal ions was also demonstrated by isothermal titration calorimetry. The new derivatives exhibited high acetylcholinesterase inhibitory activity, high blood-brain barrier penetration ability and high chelating selectivity for Zn.

Novel sampangine derivatives as potent inhibitors of Cu-mediated amyloid-β protein aggregation, oxidative stress and inflammation.

A series of 11-substituted sampangine derivatives have been designed, synthesized, and tested for their ability to inhibit cholinesterase. Their chelating ability and selectivity for Cu over other biologically relevant metal ions were demonstrated by isothermal titration calorimetry. Their blood-brain barrier permeability was also tested by parallel artificial membrane permeation assay.

Critical role of dysfunctional mitochondria and defective mitophagy in autism spectrum disorders.

Autism spectrum disorders (ASDs) are a group of complex neurodevelopmental disorders, including autistic disorder, Asperger's syndrome, pervasive developmental disorder and childhood disintegrative disorder. Mitochondria not only provide neurons with energy in the form of ATP to sustain neuron growth, proliferation and neurodevelopment, but also regulate neuron apoptosis, intracellular calcium ion (Ca) homeostasis, and reactive oxygen species (ROS) clearance. Due to their postmitotic state and high energy-demanded feature, neurons are particularly prone to mitophagy and mitochondrial disfunction.

Surface polaron states on single-crystal rutile TiO nanorod arrays enhancing charge separation and transfer.

Polaron states on TiO2 photoanodes provide an important electron transfer pathway at the electrode-electrolyte interface. Here, we electrochemically doped single-crystal rutile TiO2 nanorod arrays with exposed (110) facets to produce surface polaron states, Ti3+-OH, which greatly contributed to charge separation and transfer. Our results experimentally clarified the previously confused understanding of the origin of improved photoelectrochemical (PEC) water splitting performance and verified that the enhanced PEC effects mainly arise from surface polaron states instead of grain boundary passivation.

One-step synthesis of IrO-decorated ultrathin NiFe LDH nanosheets for efficient oxygen evolution reaction.

The oxygen evolution reaction (OER) is a vital proton donor for various clean energy technologies. Here, we synthesized IrOx-decorated ultrathin NiFe-LDH nanosheets (thickness 1-2 nm) by a one-step co-precipitation method. The IrOx was uniformly dispersed on the surface of ultrathin NiFe-LDH nanosheets, greatly increasing the active sites and the electric conductivity for NiFe-LDH.

Inhibitory potency of 4- substituted sampangine derivatives toward Cu mediated aggregation of amyloid β-peptide, oxidative stress, and inflammation in Alzheimer's disease.

Cu plays a key role in the pathogenesis of Alzheimer's disease (AD). The dysregulation of Cu can cause neuronal damage and aggravate development of AD. Moreover, a series of 4-substituted sampangine derivatives have been investigated as inhibitors of acetylcholinesterase and β-amyloid (Aβ) aggregation for the treatment of AD in our previous studies.

Use of preoperative erythropoietin therapy to facilitate autologous blood donation in orthopedic surgery: A meta-analysis.

Background: Autologous blood transfusion helps to avoid or reduce the need for allogenic blood transfusion in patients undergoing major surgery. We examined the value of erythropoietin therapy to support preoperative autologous blood donation (PABD) in patients undergoing orthopedic surgery.

Methods: For this systematic review and meta-analysis, Medline, Cochrane, EMBASE, and Google Scholar databases were searched from October 26th, 1989 until September 30th, 2017.

Inhibiting Hydrogen Evolution using a Chloride Adlayer for Efficient Electrochemical CO Reduction on Zn Electrodes.

A challenge in electrochemical CO reduction is inhibiting hydrogen evolution reaction (HER). Herein, a bulk Zn electrode was chosen to reveal the effect of specifically adsorbed Cl ions on HER during CO reduction. We found that in the Cl ion-containing electrolyte, the Zn-Cl adlayer formed because the weakly solvated Cl ions can strip the solvation shell and form a direct chemical bond with the metal Zn.

Nanoscale Crystalline Sheets and Vesicles Assembled from Nonplanar Cyclic -Conjugated Molecules.

A fundamental challenge in chemistry and materials science is to create new carbon nanomaterials by assembling structurally unique carbon building blocks, such as nonplanar -conjugated cyclic molecules. However, self-assembly of such cyclic -molecules to form organized nanostructures has been rarely explored despite intensive studies on their chemical synthesis. Here we synthesized a family of new cycloparaphenylenes and found that these fully hydrophobic and nonplanar cyclic -molecules could self-assemble into structurally distinct two-dimensional crystalline multilayer nanosheets.