Publications by authors named "Huang Sheng-Jie"

A facile and highly efficient visible-light photoredox-catalyzed protocol for aryldifluoromethylation of acrylamides was developed using -(difluoromethyl)sulfonium salt as the difluoromethyl source. With this method, pharmaceutically interesting CFH-containing oxindoles were readily accessed from -arylacrylamides, and this method featured mild reaction conditions, a broad scope of substrates, good tolerance of functional groups, and good to excellent yields. Control experiments revealed that this protocol proceeded through a difluoromethylation/cyclization cascade process.

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Sepsis is a life-threatening organ dysfunction caused by the maladjustment of the body's response to infection. Abnormal immune response plays an important role in the progression of sepsis, and immunomodulatory therapy is a promising therapeutic strategy for sepsis. Great efforts have been made recently to elucidate the mechanism by which immune dysfunction contributes to sepsis, and identify potential biomarkers and targets for the diagnosis and therapy of sepsis induced by emerging pathogens, especially for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes COVID-19.

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Article Synopsis
  • Sepsis is a serious condition resulting from the body's improper response to infection, with TLR-4 playing a crucial role in inflammation and immune cell death.
  • Clinical trials using monoclonal antibodies targeting TLR-4 and immunotherapy focusing on inflammatory cytokines have not been successful in treating sepsis.
  • Recent research suggests that the innate immune system is more important for controlling sepsis progression than the adaptive immune system, leading to a proposed shift in treatment strategies and highlighting the potential role of TREML4 in sepsis management.
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Article Synopsis
  • - SARS-CoV-2 causes a global health crisis due to its high infectivity and rapid spread, leading to severe cases of COVID-19 with complications.
  • - Advances in understanding SARS-CoV-2's molecular biology have revealed various laboratory biomarkers that can aid in diagnosing, treating, and predicting patient outcomes for COVID-19.
  • - This review highlights the current progress in identifying COVID-19-related biomarkers and suggests future approaches for their application in clinical settings.
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Polyethylene glycol (PEG) surface film-forming method was used to prepare hydrophilic Indigo Naturalis decoction pieces with stable effect.The preparation process of modified Indigo Naturalis was optimized and its microscopic properties,hydrophilicity,antipyretic efficacy,and safety were systematically evaluated.With equilibrium contact angle as assessment index,the influence of modifier type,modifier dosage,dispersant dosage,and co-grinding time on water solubility of Indigo Naturalis was investigated by single factor test.

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Background: Indigo naturalis is a blue dye in ancient, as well as an extensive used traditional Chinese medicine. It has a wide spectrum of pharmacological properties and can be used to treat numerous ailments such as leukemia, psoriasis, and ulcerative colitis. This article aims to expand our understanding of indigo naturalis in terms of its chemical constituents, pharmacological action and clinical applications.

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Sepsis is an important disorder in intensive care medicine, and the emphasis is not on infections but the imbalance in body reactions and life-threatening organ dysfunction. The infection, the imbalance in the body's reaction, and the deadly organ dysfunction are three aspects of sepsis. Currently, there is still a debate on suitable criteria for the diagnosis of patients with sepsis with continuing changes in the guidelines on sepsis management.

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Inflammatory bowel disease (IBD) is a global health problem in which gut microbiota dysbiosis plays an important pathogenic role. However, the current drugs for IBD treatment are far from optimal. Previous researches indicated that parthenolide (PTL) had not only anti-cancer properties but also strong anti-inflammatory activities.

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Article Synopsis
  • The text discusses a new method for constructing and classifying topological states that are protected by both onsite and spatial symmetry groups.
  • It introduces the concept of "topological crystals," where these states are arranged in a specific spatial configuration without open edges, making them stable under symmetry transformations.
  • The authors provide a detailed enumeration of all unique types of topological crystals for certain electronic insulators, leading to a comprehensive classification of topological crystalline insulators.
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