Short-term predictive value of sST2 in patients with STEMI following primary PCI: a prospective observational study.

Aim: The objective of this study was to investigate the level of soluble suppression of tumorigenicity-2 (sST2) in patients with acute ST-segment elevation myocardial infarction (STEMI) following primary percutaneous coronary intervention (PCI), and to provide a new biomarker for clinical management and prognosis assessment.

Method: This was a prospective study. 148 STEMI patients following primary PCI were enrolled and divided into 2 groups by the median value of sST2 and afterwards followed up for 30 days to access the occurrence of major adverse cardiac events (MACEs), which were defined as cardiovascular death, heart failure and recurrent MI.

Inhibition of aortic CX3CR1+ macrophages mitigates thoracic aortic aneurysm progression in Marfan syndrome in mice.

The pathogenesis of thoracic aortic aneurysm (TAA) in Marfan syndrome (MFS) is generally attributed to vascular smooth muscle cell (VSMC) pathologies. However, the role of immune cell-mediated inflammation remains elusive. Single-cell RNA sequencing identified a subset of CX3CR1+ macrophages mainly located in the intima in the aortic roots and ascending aortas of Fbn1C1041G/+ mice, further validated in MFS patients.

Bioinformatics-based analysis of the role of immune-related genes in acute rejection after kidney transplantation and renal cancer development.

Acute rejection (AR) is a common complication in the early stage after kidney transplantation. Some studies have shown that the occurrence of AR after kidney transplantation may further affect the development of tumors, and both AR and tumor development are related to immune cells and immune genes, so it is particularly important to diagnose the occurrence of AR at an early stage and to analyze the correlation between AR and tumors. In this study, we applied bioinformatics techniques for differential expression analysis and weighted gene co-expression network analysis analysis of AR patients to obtain differentially expressed genes and modular genes significantly associated with AR, respectively, so as to obtain their intersecting genes with immune-related genes; 21 intersecting genes were screened by lasso regression and Boruta algorithm to obtain the genes, and finally, the feature genes that were significantly associated with the dependent variable were further obtained by single-factor and multi-factor logistic regression.

KNG1 mutations (c.618 T > G and c.1165C > T) cause disruption of the Cys206-Cys218 disulfide bond and truncation of the D5 domain leading to hereditary high molecular weight kininogen deficiency.

Background: High molecular weight kininogen (HMWK), encoded by the kininogen-1 (KNG1) gene, is a multifunctional glycoprotein closely associated with the initiation of blood coagulation, tumor growth, and other pathological processes.

Objective: We conducted a study on the clinical phenotype, genetic mutations, and molecular pathogenesis of a female patient with uterine leiomyosarcoma, who presented with HMWK deficiency and an isolated prolonged activated partial thromboplastin time (APTT).

Methods: Clinical phenotyping was conducted through APTT mixing studies, quantitative assessments of intrinsic coagulation factor activities, antigen levels of HMWK, and thromboelastography.

Prenylation-dependent membrane localization of a deubiquitinating enzyme and its role in regulating G protein-mediated signaling in yeast.

Miy1 is a highly conserved de-ubiquitinating enzyme in yeast with MINDY1 as its human homolog. Miy1 is known to act on K48-linked polyubiquitin chain, but its biological function is unknown. Miy1 has a putative prenylation site, suggesting it as a membrane-associated protein that may contribute to the regulation of cell signaling.

A scientific-article key-insight extraction system based on multi-actor of fine-tuned open-source large language models.

The exponential growth of scientific articles has presented challenges in information organization and extraction. Automation is urgently needed to streamline literature reviews and enhance insight extraction. We explore the potential of Large Language Models (LLMs) in key-insights extraction from scientific articles, including OpenAI's GPT-4.

Impact of Noise on Medical Anxiety in Hospitalized Children with Pneumonia: A Retrospective Study.

Purpose: Noise levels may have an impact on the level of fear and anxiety in hospitalized children, which, in turn, may affect the effectiveness of treatment. This retrospective study aimed to investigate the impact of noise levels on medical anxiety in hospitalized children with pneumonia.

Methods: Children hospitalized for pneumonia in our hospital from January 2020 to December 2023 were consecutively enrolled in this study.

Semaglutide vs. dulaglutide for glycemic and weight control in patients with type 2 diabetes mellitus: A systematic review and meta‑analysis.

The present systematic review and meta-analysis aimed to evaluate the effectiveness of semaglutide and dulaglutide for glycemic control and weight loss in patients with type 2 diabetes mellitus (T2DM). A thorough literature search was conducted using several databases from inception until the end of July 2024. The primary outcome was the difference in glycated hemoglobin levels from the initial measurement between the groups.

Knockdown of GSDMD inhibits pyroptosis in psoriasis by blocking the NOD-like receptor signaling pathway.

Background: Psoriasis is a chronic inflammatory skin disease regulated by autoimmunity, and pyroptosis plays an important role in this condition. This research sought to examine the function and potential molecular pathway of Gasdermin D (GSDMD) in psoriasis.

Methods: GSDMD expression was examined by immunohistochemistry in biopsied skin tissues from patients with psoriasis.

Differential Expression and Distribution of Slco4a1 and Slco1b2 in an Internal Environment Disorder-induced Hepatocellular Carcinoma Mouse Model.

Objective: This study aims to enhance the understanding of underlying mechanisms and potential therapies of the solute carrier organic anion (SLCO) transporter family in internal environment disorder (IED)-induced hepatocellular carcinoma (HCC). This could lead to new therapeutic strategies and offer new directions for the creation of new patents for HCC treatment products.

Methods: The orthotopic transplantation (OT), IED and IED-based OT (IED-OT) mouse models were established.

Exploring the Crystal Landscape of Mandelamide and Chiral Resolution via Cocrystallization.

The crystal structures of (±)-mandelamide, -mandelamide, and enantioenriched mandelamide (94 : 6 ) were determined. Diastereomeric cocrystal pairs of -mandelamide with both enantiomers of mandelic acid and proline were synthesized. The diastereomeric cocrystal pairs of -mandelamide with /-mandelic acid form 1:1 cocrystals in each case, while the diastereomeric cocrystal pairs of -mandelamide with proline have different stoichiometries.

Near-infrared-II-driven Z-scheme heterojunction Polyglycolated MoS/CoFeO amplified edge potential for dual-mode imaging guided tumor synergistic therapy.

Targeting the peculiarities of tumor tissue microenvironment different from normal tissue, such as lower pH and overexpression of hydrogen peroxide is the key to effective treatment. In this study, acid-responsive Z-scheme heterojunctions polyglycolated MoS/CoFeO (MoS = molybdenum disulfide, CoFeO = cobalt ferrite) was synthesized using a two-step hydrothermal method, designated as MSCO-PEG, guided by dual modes of photoacoustic imagine (PAI) and nuclear magnetic imaging (MRI). MSCO-PEG (PEG = polyethylene glycol) responded to the acidic environment of tumor tissues and overexpression of hydrogen peroxide to turn on multimodal synergistic treatment of tumor cells under near-infrared-II (NIR-II) illumination.

Roles of blood monocytes carrying TREM2 mutation in pathogenesis of Alzheimer's disease and its therapeutic potential in APP/PS1 mice.

Introduction: The triggering receptor expressed on myeloid cells 2 (TREM2) arginine-47-histidine (R47H) mutation is a significant risk for Alzheimer's disease (AD) with unclear mechanisms. Previous studies focused on microglial amyloid-β (Aβ) phagocytosis with less attention on the impact of TREM2 mutation on blood monocytes.

Methods: Bone marrow transplantation (BMT) models were used to assess the contribution of blood monocytes carrying TREM2 mutation to AD.

SND1-SMARCA5 interaction strengthened by PIM promotes the proliferation, metastasis, and chemoresistance of esophageal squamous cell carcinoma.

Chromatin remodeling plays a pivotal role in the progression of esophageal squamous cell carcinoma (ESCC), but the precise mechanisms remain poorly understood. Here, we elucidated the critical function of staphylococcal nuclease and tudor domain-containing 1 (SND1) in modulating chromatin dynamics, thereby driving ESCC progression in both in vitro and in vivo models. Our data revealed that SND1 was markedly overexpressed in ESCC cell lines.

A Generalized Multi-Detector Combination Approach for Differential Item Functioning Detection.

Many studies on differential item functioning (DIF) detection rely on single detection methods (SDMs), each of which necessitates specific assumptions that may not always be validated. Using an inappropriate SDM can lead to diminished accuracy in DIF detection. To address this limitation, a novel multi-detector combination (MDC) approach is proposed.

[Sulforaphane alleviates acute liver injury induced by diquat in mice by activating Keap1/Nrf2 signaling pathway].

Objective: To investigate the protective effect and possible mechanism of sulforaphane (SFN) on acute liver injury in mice induced by diquat (DQ) poisoning.

Methods: Forty-eight male C57BL/6 mice were divided into Control group, DQ model group (DQ group), SFN intervention group (DQ+SFN group), and SFN control group (SFN group) using a random number table method, with 12 mice in each group. Acute liver injury mice model was established by one-time intraperitoneal injection of 1 mL of 40 mg/kg DQ solution at once.

Mediating effect of physical activity on the relationship between high dietary live microbe intake and obesity among U.S adolescents, finding from NHANES 1999-2018.

Background And Aims: The impact of dietary live microbe intake on adolescent obesity is still not fully understood. This study aims to investigate the potential relationship between dietary live microbe intake and obesity among U.S adolescents, and to explore the mediating role of physical activity (PA).

Pesticide exposures and 10-year atherosclerotic cardiovascular disease risk: Integrated epidemiological and bioinformatics analysis.

Background And Purpose: Recent studies link pesticide exposures to cardiovascular disease risk factors. However, research on the combined effects of multiple pesticides on atherosclerotic cardiovascular disease (ASCVD) is limited, particularly in rural areas. Despite advances in toxicogenomics, the mechanisms underlying these effects remain unclear.

Development and external validation of a prediction model for the risk of relapse in psoriasis after discontinuation of biologics.

Background: Some patients with psoriasis experience relapses shortly after discontinuation of biologics. However, there is a lack of risk prediction tools to identify those at high risk of relapse.

Objective: To develop and validate a risk prediction model for psoriasis relapse after biologics discontinuation.

The matrix protease ADAMTS1 is transcriptionally activated by KLF6 and contributes to cardiac fibrosis in non-ischemic cardiomyopathy.

Aims: Aberrant cardiac fibrosis, defined as excessive production and deposition of extracellular matrix (ECM), is mediated by myofibroblasts. ECM-producing myofibroblasts are primarily derived from resident fibroblasts during cardiac fibrosis. The mechanism underlying fibroblast-myofibroblast transition is not fully understood.

Comparative proteotranscriptomic analysis of four carpenter moth species reveals key salivary proteins related to feeding adaptations.

Salivary proteins play a crucial role in insects, facilitating nutrient acquisition and regulating complex interactions with host plants. However, most research has focused on pierce-sucking insects, leaving chewing insects, such as caterpillars largely unexplored. Carpenter moths (Cossidae) are important destructive wood bores whose larvae cause significant damage to forestry.

Analyte-initiated disassembly of electrochromic metal-organic framework-based nanocomposites for smart colorimetric sensing.

An electrochromic (EC) sensing strategy was presented through analyte-induced disassembly of an EC metal-organic framework-based nanocomposite. Carbon dots underwent charge reversion to separate from the entity stimulated by analytes, acting as a nanoswitch of the EC activity. We achieved colorimetric detection of glucose the EC activity recovery mediated by released protons during glucose oxidation.

Molecular identification of TRAF4 gene in aquatic keystone species Daphnia magna and its response to toxic cyanobacteria challenge.

Cyanobacterial blooms, which are becoming more frequent in aquatic ecosystems across the globe, pose a significant health threat to the aquatic keystone species, Daphnia magna. Given that D. magna solely rely on innate immunity centered around tumor necrosis factor receptor-associated factor 4 (TRAF4), the aim of this study is to analyze how the TRAF4 gene in D.

Mechanically stabilized UiO-66-NH-MB screen printed carbon electrode for high-performance electrochemical ratiometric quantification of miR-21-5p.

The ratiometric sensing strategy, which uses dual-signal output, drastically compensates for the background noise and interference from the detection environment, compared to the sensing methods that rely on a single-signal output. However, the stability of the reference signal has become the primary challenge in constructing a ratiometric detection sensor. Therefore, in order to achieve stable ratiometric signal sensing, methylene blue (MB) was encapsulated in the UiO-66-NH framework and printed as a reference signal onto a screen-printed carbon electrode (SPCE), facilitating the precise detection of miR-21-5p.