Publications by authors named "Huang Jia-Xin"
Objective: To develop a model for accurate prediction of axillary lymph node (LN) status after neoadjuvant chemotherapy (NAC) in breast cancer patients with nodal involvement.
Methods: Between October 2018 and February 2024, 671 breast cancer patients with biopsy-proven LN metastasis who received NAC followed by axillary LN dissection were enrolled in this prospective, multicenter study. Preoperative ultrasound (US) images, including B-mode ultrasound (BUS) and shear wave elastography (SWE), were obtained.
Purpose: To develop a combined approach using shear wave elastography (SWE) and conventional ultrasound (US) to determine the extent of positive axillary lymph nodes (LNs) following neoadjuvant therapy (NAT) in breast cancer patients with nodal involvement.
Methods: This prospective, multicenter study was registered on the Chinese Clinical Trial Registry (ChiCTR2400085035). From October 2018 to February 2024, a total of 303 breast cancer patients with biopsy-proven positive LN were enrolled.
In a cohort of 2303 children with type 1 diabetes (T1D), we found that non-English speaking status (HR 2.82, 95% CI 1.54-5.
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- - The study aims to explore the relationship between sarcopenia (muscle loss) and outcomes in patients with extensive small-cell lung cancer (SCLC) treated with first-line immunochemotherapy, involving 63 patients over a two-year period.
- - Results showed that 19% of the patients had sarcopenia, which was linked to older age, lower BMI, reduced grip strength, and lower albumin levels, as well as a poorer response to treatment (30% vs. 79% response rate).
- - Overall survival was significantly shorter for patients with sarcopenia, averaging 9 months compared to 24 months for those without sarcopenia, despite similar rates of chemotherapy-related side effects.
Article Synopsis
- Identifying axillary pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) in breast cancer patients is difficult, prompting the investigation of shear wave elastography (SWE) for prediction accuracy.* -
- This study analyzed the correlation between shear wave velocity (SWV) and pathologic traits in tumors and lymph nodes of 319 breast cancer patients, revealing stronger relationships in breast tumors than in axillary lymph nodes.* -
- The results show that SWE is more effective for predicting axillary pCR when performed on breast tumors (AUC 0.87) compared to axillary lymph nodes (AUC 0.70), indicating its potential as a useful tool in breast cancer assessment
Article Synopsis
- This study investigated the calf proportion index (CPI) to assess its relationship with malnutrition and survival in overweight and obese cancer patients.
- The research included 3,499 patients and found that lower CPI values were correlated with higher mortality and greater risk of malnutrition, especially in obese individuals.
- The CPI proved to be a more effective predictor of survival than other measurements, and specific cut-off values were identified (0.65% for men, 0.57% for women) to determine risk levels.
Article Synopsis
- Older cancer patients face increased risks of malnutrition and decreased quality of life (QoL), prompting a study on the correlation between malnutrition and QoL using GLIM criteria for diagnosis.
- This study included over 5,300 older cancer patients, revealing that those with malnutrition had lower QoL scores, with severe malnutrition having the most significant impact on QoL.
- The findings indicated that both malnutrition and QoL are critical factors in predicting survival for older cancer patients, particularly for those with lung and gastric cancers.
In a cohort of 1817 children with type 1 diabetes (T1D), short-term hyperglycemia was associated with transient albuminuria (11 % during new-onset T1D without diabetic ketoacidosis (DKA), 12 % during/after DKA, 6 % during routine screening). Our findings have implications regarding future risk of diabetic kidney disease and further investigation is needed.
View Article and Find Full Text PDFContrast-enhanced Imaging in Peripheral Pulmonary Lesions: The Role in US-guided Biopsies.
Radiol Cardiothorac Imaging
June 2024
Purpose To compare the tissue adequacy and diagnostic accuracy of US-guided biopsies of peripheral pulmonary lesions (PPLs) with and without contrast agents. Materials and Methods A retrospective study was conducted at four medical centers in patients with PPLs who underwent US-guided percutaneous transthoracic needle biopsy (PTNB) between January 2017 and October 2022. The patients were divided into contrast-enhanced US (CEUS) and US groups based on whether prebiopsy CEUS evaluation was performed.
View Article and Find Full Text PDFBackground: To develop a convenient modality to predict axillary response to neoadjuvant chemotherapy (NAC) in breast cancer patients.
Materials And Methods: In this multi-center study, a total of 1019 breast cancer patients with biopsy-proven positive lymph node (LN) receiving NAC were randomly assigned to the training and validation groups at a ratio of 7:3. Clinicopathologic and ultrasound (US) characteristics of both primary tumors and LNs were used to develop corresponding prediction models, and a nomogram integrating clinicopathologic and US predictors was generated to predict the axillary response to NAC.
Article Synopsis
- This study investigated the prognostic value of hepatic proteins (albumin, prealbumin, and transferrin) in predicting survival outcomes for patients with cancer cachexia, a condition marked by severe weight loss and muscle wasting.
- In a cohort of 1,303 patients, low levels of these proteins were associated with higher mortality rates, confirming their role as independent risk factors for long-term survival in various types of cancer.
- The findings highlighted that albumin was the strongest predictor of survival, especially in patients with certain cancers like upper gastrointestinal and colorectal types, emphasizing the importance of monitoring these protein levels in cancer care.
Purpose: Our study aimed to comprehensively analyze the association between anemia and systemic inflammation in older patients with cancer.
Methods: This multicenter prospective cohort study included 4955 older patients with cancer between 2013 and 2020. Logistic regression analysis was performed to investigate risk factors of anemia, reporting odds ratios (ORs), and 95% confidence intervals (CIs).
Objectives: To evaluate for associations between a child's neighborhood, as categorized by Child Opportunity Index (COI 2.0), and 1) PICU mortality, 2) severity of illness at PICU admission, and 3) PICU length of stay (LOS).
Design: Retrospective cohort study.
Rationale And Objectives: To develop a monitoring model using radiomics analysis based on longitudinal B-mode ultrasound (BUS) and shear wave elastography (SWE) to early predict pathological response to neoadjuvant chemotherapy (NAC) in breast cancer patients.
Materials And Methods: In this prospective study, 112 breast cancer patients who received NAC between September 2016 and March 2022 were included. The BUS and SWE data of breast cancer were obtained prior to treatment as well as after two and four cycles of NAC.
A promising prognostic grading system incorporating weight loss and inflammation in patients with advanced cancer.
J Cachexia Sarcopenia Muscle
December 2023
Background: Involuntary weight loss and increased systemic response are frequently observed in patients with cancer, especially in advanced stages. This study aimed to develop a powerful weight loss and inflammation grading system (WLAIGS) and investigate its prognostic performance in patients with advanced cancer.
Methods: This multicentre prospective cohort study included 11 423 patients with advanced cancer.
Background: Malnutrition and systemic inflammation are considered 2 hallmarks of cancer cachexia. Our study aimed to construct a modified Controlling Nutritional Status by introducing C-reactive protein as an inflammatory parameter and investigate its prognostic value in patients with cancer cachexia.
Methods: This multicenter cohort study included 5221 patients with cancer, among whom 1719 were diagnosed with cachexia.
Background: Malnutrition and increased systemic inflammatory responses are highly prevalent in patients with cancer and they have a negative effect on prognosis. We aimed to develop a nutrition-inflammation prognostic grading system (NIPGS) for patients with cancer, which incorporates the Nutritional Risk Screening 2002 (NRS 2002) and C-reactive protein (CRP) levels.
Methods: This multicenter retrospective cohort study totally included 6891 patients diagnosed with cancer.
Background: The coronavirus disease 2019 (COVID-19) pandemic has resulted in infections among patients with cancer. Our study aimed to investigate the potential adverse impact of anti-cancer treatments within 2 weeks of COVID-19 infection on clinical outcomes in patients with cancer.
Methods: This retrospective cohort study analyzed 70 cancer patients with COVID-19 infection from the First Hospital of Jilin University in Changchun City, Jilin Province, between March and June 2022.
Background: Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive primary liver cancer, with increasing incidence worldwide. Effective first-line treatments for advanced ICC patients are currently limited. Therefore, our study aimed to assess the efficacy and safety of programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors in combination with gemcitabine/cisplatin (GC) and lenvatinib as first-line treatment in advanced ICC patients.
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- A study analyzed radiomics and deep convolutional neural networks (CNN) using ultrasound methods to predict how well breast cancer patients respond to neoadjuvant chemotherapy (NAC).
- A total of 255 patients were included, and models were created using B-mode ultrasound (BUS) and shear wave elastography (SWE) images, with CNN models performing better than traditional radiomics methods.
- The best predictive performance came from a CNN model that combined dual-modal ultrasound data and clinicopathologic characteristics, achieving an accuracy of over 83%, suggesting it could be used as a non-invasive tool to help tailor chemotherapy treatment for patients.
Article Synopsis
- - Neuregulin 4 (NRG4) is a vital adipocytokine involved in energy balance and preventing non-alcoholic fatty liver disease, with significant genomic, transcript, and protein studies done on humans, while chicken NRG4 (cNRG4) remains less understood.
- - This research systematically explored the genomic and transcriptional structure of the cNRG4 gene using techniques like RACE and RT-PCR, revealing a small coding region but a complex transcriptional framework with multiple start sites and isoforms.
- - The cNRG4 gene spans 21,969 bp on chicken chromosome 10, contains 11 exons and 10 introns, and can produce three protein isoforms, providing a
Objectives: Bronchiolitis is the most common cause for nonelective infant hospitalization in the United States with increasing utilization of high-flow nasal cannula (HFNC). We standardized initiation and weaning of HFNC for bronchiolitis and quantified the impact on outcomes. Our specific aim was to reduce hospital and ICU length of stay (LOS) by 10% between two bronchiolitis seasons after implementation.
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- - The study compared ultrasound (US) and contrast-enhanced ultrasound (CEUS) for liver biopsies in 820 patients with focal liver lesions (FLLs) and found that CEUS significantly increased sample adequacy and diagnostic accuracy compared to US.
- - CEUS resulted in better sensitivity and accuracy, particularly for larger or challenging FLLs, and showed improved performance in single-puncture biopsies.
- - The findings suggest that CEUS enhances the safety and effectiveness of liver biopsies by reducing the number of punctures needed while achieving higher success rates.
Objective: To determine the ability of conventional ultrasound (US) combined with shear wave elastography (SWE) to reveal axillary status after neoadjuvant chemotherapy (NAC) in breast cancer patients.
Methods: From September 2016 to December 2021, 201 patients with node-positive breast cancer who underwent NAC were enrolled in this prospective study. Conventional US features of axillary lymph nodes and SWE characteristics of breast lesions after NAC were analyzed.