Self-Supervised Transfer Learning Based on Domain Adaptation for Benign-Malignant Lung Nodule Classification on Thoracic CT.

The spatial heterogeneity is an important indicator of the malignancy of lung nodules in lung cancer diagnosis. Compared with 2D nodule CT images, the 3D volumes with entire nodule objects hold richer discriminative information. However, for deep learning methods driven by massive data, effectively capturing the 3D discriminative features of nodules in limited labeled samples is a challenging task.

Fomite Transmission Follows Invasion Ecology Principles.

The invasion ecology principles illustrated in many ecosystems have not yet been explored in the context of fomite transmission. We hypothesized that invaders in fomite transmission are trackable, are neutrally distributed between hands and environmental surfaces, and exhibit a proximity effect. To test this hypothesis, a surrogate invader, Lactobacillus delbrueckii subsp.

Genetic predisposition to papillary thyroid carcinoma is mediated by a long non-coding RNA TINCR enhancer polymorphism.

Single nucleotide polymorphisms (SNPs) in the enhancer region have been demonstrated to confer to altered enhancer activities, aberrant gene expression, and cancer susceptibility. In this study, we aimed to examine the association between an SNP, rs8101923, within terminal differentiation-induced non-coding RNA (TINCR) and the risk of papillary thyroid carcinoma (PTC). Blood samples from 559 patients with PTC and 445 healthy individuals were collected.

Nutritional value and bioaccumulation of heavy metals in nine commercial fish species from Dachen Fishing Ground, East China Sea.

The study evaluated the nutritional quality in muscle tissues of nine commercially important marine fish species. And the concentrations of trace metals (i.e.

Acetylation of SCFD1 regulates SNARE complex formation and autophagosome-lysosome fusion.

SCFD1 (sec1 family domain containing 1) was recently shown to function in autophagosome-lysosome fusion, and multiple studies have demonstrated the regulatory impacts of acetylation (a post-translational modification) on macroautophagy/autophagy. Here, we demonstrate that both acetylation- and phosphorylation-dependent mechanisms control SCFD1's function in autophagosome-lysosome fusion. After detecting a decrease in the extent of SCFD1 acetylation under autophagy-stimulated conditions, we found that KAT2B/PCAF catalyzes the acetylation of residues K126 and K515 of SCFD1; we also showed that these two residues are deacetylated by SIRT4.

Intervention Mechanism of Hunag-Lian Jie-Du Decoction on Canonical Wnt/-Catenin Signaling Pathway in Psoriasis Mouse Model.

Background: Psoriasis is a common chronic inflammatory skin disease with multifactor etiology, characterized by abnormal proliferation and differentiation of keratinocytes. Huang-Lian Jie-Du decoction (HLJDD) is a traditional Chinese medicine prescription with good clinical curative effect on psoriasis. However, its therapeutic mechanisms are still unclear.

The diagnostic value of blood cell-derived indexes in subacute thyroiditis patients with thyrotoxicosis: a retrospective study.

Background: Both subacute thyroiditis (SAT) and Graves' disease (GD) can lead to thyrotoxicosis, but the methods to distinguish these two diseases are relatively complex. Therefore, it is necessary to find biomarkers which can quickly and efficiently identify the two kinds of thyrotoxicosis. Blood cell-derived indexes are widely used to evaluate systemic inflammation.

Topological magnon modes on honeycomb lattice with coupling textures.

Topological magnon modes are expected to be useful for novel applications such as robust information propagation, since they are immune to backscattering and robust against disorder. Although there are several theoretical proposals for topological magnon modes and growing experimental efforts for realizing them by now, it is still desirable to add complementary insights on this important phenomenon. Here, we propose a new scheme to achieve topological magnon where only nearest-neighbour exchange couplings on honeycomb lattice are necessary.

Experimental and theoretical study of ZrMo-KIT-6 solid acid catalyst with abundant Brønsted acid sites.

Given their excellent reusability and environmental friendliness, solid acid catalysts have drawn considerable attention in acid-catalyzed reactions. However, the rational design and synthesis of solid acid catalysts with abundant Brønsted acid sites remains a challenge. In this paper, KIT-6, Zr-KIT-6, Mo-KIT-6, and ZrMo-KIT-6 solid acid catalysts are designed and synthesized.

Low-dose glucocorticoids withdrawn in systemic lupus erythematosus: a desirable and attainable goal.

Objectives: To assess the risk of flare in systemic lupus erythematosus (SLE) patients after low-dose glucocorticoid (GC) discontinuation and to evaluate the risk factors of flare.

Methods: SLE patients who ever discontinued GCs were identified from the Peking University First Hospital SLE cohort. The disease flare profile after GC discontinuation was analysed.

Discriminant models for the prediction of postponed viral shedding time and disease progression in COVID-19.

Background: COVID-19 infection can cause life-threatening respiratory disease. This study aimed to fully characterize the clinical features associated with postponed viral shedding time and disease progression, then develop and validate two prognostic discriminant models.

Methods: This study included 125 hospitalized patients with COVID-19, for whom 44 parameters were recorded, including age, gender, underlying comorbidities, epidemiological features, laboratory indexes, imaging characteristics and therapeutic regimen, et al.

Towards a Better Implementation of Treat-to-Target Strategy in Rheumatoid Arthritis: A Comparison of Two Real-World Cohorts.

Introduction: Treat-to-target (T2T) strategy has been the core of rheumatoid arthritis (RA) management for over a decade, although it implementation has varied distinctly in real practices. We report here our investigation of the differences in disease activity and target achievement of two patient cohorts with different T2T implementations.

Methods: Data of the CENTRA (Collaboratively intENsive Treat-to-target in RA) and TARRA (Treat-to-TARget in RA) cohorts were used.

Structure-switchable aptamer-arranged reconfigurable DNA nanonetworks for targeted cancer therapy.

The structural DNA nanotechnology holds great potential application in bioimaging, drug delivery and cancer therapy. Herein, an intelligent aptamer-incorporated DNA nanonetwork (Apt-Nnes) is demonstrated for cancer cell imaging and targeted drug delivery, which essentially is a micron-scale pattern with the thickness of double-stranded monolayer. Cancer cell-surface receptors can make it perform magical transformation into small size of nanosheet intermediates and specifically enter target cells.

A relationship among the blood serum levels of interleukin-6, albumin, and 25-hydroxyvitamin D and frailty in elderly patients with chronic coronary syndrome.

Background: With the aggravation of the aging of the world population, frailty has become one of the common complications in elderly people. Its diagnosis is not objective, the pathogenesis is not clear, and interventions are not sound, thus intensifying the problem. Furthermore, frailty is closely associated with the occurrence and poor prognosis of coronary atherosclerotic heart disease.

A pH-Driven indomethacin-loaded nanomedicine for effective rheumatoid arthritis therapy by combining with photothermal therapy.

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterised by inflammatory micro-environments in the joints. Indomethacin (IND), a conventional nonsteroidal anti-inflammatory drug (NSAID), has been used for the therapy of RA. However, the poor solubility and serious side effects of oral administration of IND significantly limit its efficacy.

Engineered Bacteria EcN-MT Alleviate Liver Injury in Cadmium-Exposed Mice its Probiotics Characteristics and Expressing of Metallothionein.

Cadmium (Cd) exposure is a widespread problem in many parts of the world, but effective means to treat Cd exposure is still lacking. Hence, an engineered strain expressing metallothionein (MT) named Nissle 1917 (EcN)-MT was constructed, and its potential in the treatment of Cd exposure was evaluated. The studies showed that metallothionein expressed by EcN-MT could significantly bind Cd.

Clinicopathological features of non-conventional renal cell carcinoma histological subtypes: Learning points from a large contemporary series spanning over three decades.

Purpose: To perform a retrospective review of the clinicopathological features of patients with conventional and non-conventional renal cell carcinoma (cRCC and ncRCC).

Materials And Methods: A large prospectively maintained uro-oncological registry was accessed to extract clinicopathological data of patients diagnosed with renal tumors who subsequently underwent nephrectomy from 1990-2019. Demographics and operative parameters were extracted.

The Neuropsychiatric Changes After COVID-19 Quarantine in Patients With Cognitive Impairment and Their Caregivers in Chongqing, China: A Cohort Study.

Background: The follow-up study on neuropsychiatric changes after the lifting of coronavirus disease 2019 (COVID-19) quarantine in patients with cognitive impairment and their caregivers is still lacking, and relative information is needed to formulate more comprehensive healthcare prevention measures worldwide.

Aims: To provide data on the changes in neuropsychiatric performance after the lifting of COVID-19 quarantine in patients with cognitive disorders and their caregivers.

Methods: Two surveys in Chongqing, China were conducted telephonic interview with 531 patients and their caregivers.

Coupling relationship between cold chain logistics and economic development: A investigation from China.

This paper builds an evaluation index system, uses the entropy weight method (EWM) to decide the weights and, based on the coupling coordination degree model (CCDM), it systematically studies the coupling relationship between Chinese cold chain logistics and the Chinese economy from 2010 to 2019. It performs a grey relational analysis (GRE) to explore the main factors influencing the coordinated development of the two. The results show that the coupling coordination degree between the two presents a steady upward trend, and their coupling relationship has been upgraded from 'coordination' to 'good coordination'.

Aqueous Extract of Reprogramming Macrophage Polarization by Activating TLR4-NF-κB Signaling Pathway.

Purpose: (), which has been used in traditional oriental medicine for a long period, was reported to exert extensive antitumor activity, but the effect and molecular biological mechanism of on multiple myeloma (MM) has not been elaborated. Tumor-associated macrophages (TAMs) exhibit a sustained polarization between tumor killing M1 subtype and tumor supporting M2 subtype. And a lower ratio of M1/M2 is associated with tumor angiogenesis, proliferation and invasion.

Microparticles from Hyperphosphatemia-Stimulated Endothelial Cells Promote Vascular Calcification Through Astrocyte-Elevated Gene-1.

Endothelial microparticles (EMPs) can be released in chronic kidney disease (CKD). Plasma concentration of high inorganic phosphate (HP) is considered as a decisive determinant of vascular calcification in CKD. We therefore explored the role of HP-induced EMPs (HP-EMPs) in the vascular calcification and its potential mechanism.

Tenuifolin ameliorates chronic restraint stress-induced cognitive impairment in C57BL/6J mice.

The general consensus is that stress affects the central nervous system and can lead to cognitive problems. The root of Polygala tenuifolia (P. tenuifolia) is a well-known traditional Chinese medicine used for improving brain function.

The Cognitive-Enhancing Effects of Lindl Extract in Sleep Deprivation-Induced Amnesic Mice.

Chronic sleep deprivation (SD) causes neurological and neurodegenerative dysfunction including learning and memory deficit. The orchid Lindl (DNL), is widely used as a Yin tonic and medicinal food throughout Asia, and has many reported pharmacological effects. This study focused on the cognitive-enhancing effects of DNL in sleep deprivation-induced amnesia in mice and its biochemical mechanisms.