Treponema denticola major surface protein (Msp): a key player in periodontal pathogenicity and immune evasion.

Treponema denticola, a bacterium that forms a "red complex" with Porphyromonas gingivalis and Tannerella forsythia, is associated with periodontitis, pulpitis, and other oral infections. The major surface protein (Msp) is a surface glycoprotein with a relatively well-established overall domain structure (N-terminal, central and C-terminal regions) and a controversial tertiary structure. As one of the key virulence factors of T.

Sinomenine attenuates uremia vascular calcification by miR-143-5p.

Vascular calcification is considered to be a killer of the cardiovascular system, involved inflammation and immunity. There is no approved therapeutic strategy for the prevention of vascular calcification. Sinomenine exhibited anti-inflammatory and immunosuppressive effects.

5β-hydroxycostic acid from Laggera alata ameliorates sepsis-associated acute kidney injury through its anti-inflammatory and anti-ferroptosis effects via NF-κB and MAPK pathways.

Ethnopharmacological Relevance: The whole plant of Laggera alata is frequently utilize to remedy inflammatory diseases including nephritis as a traditional Chinese medicine. However, its active ingredients and mechanism of action against sepsis-associated acute kidney injury (SA-AKI) are unknown.

Aim Of The Study: This study aimed to identify active compounds from L.

GFA-Net: Geometry-Focused Attention Network for Six Degrees of Freedom Object Pose Estimation.

Six degrees of freedom (6-DoF) object pose estimation is essential for robotic grasping and autonomous driving. While estimating pose from a single RGB image is highly desirable for real-world applications, it presents significant challenges. Many approaches incorporate supplementary information, such as depth data, to derive valuable geometric characteristics.

Dihydroartemisinin ameliorates skeletal muscle atrophy in the lung cancer cachexia mouse model.

Introduction: Cancer cachexia (CC) is characterized by weight loss with specifically reduced skeletal muscles and adipose tissues in patients with late-stage cancer. Dihydroartemisinin (DHA), an effective antimalarial derivative of artemisinin, has been demonstrated to have anti-inflammatory and antitumor properties.

Materials And Methods: This study examined the effects of DHA on the Lewis lung carcinoma (LLC)-induced CC mouse model.

Understanding and addressing the global impact: A systematic review and cross-sectional bibliometric analysis of Langya henipavirus and pre-existing severe henipaviruses.

In 2022, Langya henipavirus was identified in patients with fever in eastern China. This study provides an overview of the scientific landscape, highlights research focus areas, and outlines potential future investigations. The relevant scientific literature was systematically searched and reviewed via advanced bibliometric techniques.

Unraveling the neural dichotomy of consensus and idiosyncratic experiences in short video viewing.

Human experiences are inherently shaped by individual perspectives, leading to diverse interpretations of the same events. However, shared activities, such as communal film watching or sports viewing, underscore the dual nature of these experiences: collective joy arises through social interactions, while individual emotional responses are influenced by personal preferences. The neural mechanisms underlying this interplay between shared and idiosyncratic experiences, particularly in the context of reward processing, remain insufficiently explored.

Engineered S. cerevisiae-pYD1-ScFv-AFB1 mitigates aflatoxin B1 toxicity via bio-binding and intestinal microenvironment repair.

The highly toxic aflatoxin B1 (AFB1) is considered one of the primary risk factors for hepatocellular carcinoma, while effective measures after AFB1 exposure remain to be optimized. This study utilized cell-surface-display technique to construct an engineered S. cerevisiae-pYD1-ScFv-AFB1 (S.

Signal-on lateral flow immunoassays for rapid detection of tetrodotoxin in pufferfish.

Small-molecule biotoxins are frequently founded in grains, corns, peanuts, and different kinds of aquatic products, and they are harmful to human health. Lateral flow immunoassays (LFIAs) have been widely used for on-site detection of small-molecule biotoxins. However, most of the reported LFIAs approaches are signal-off type because each small-molecule biotoxin only has one antigen binding site due to the small size of the molecule.

New insights into the role of mitophagy related gene affecting the metastasis of osteosarcoma through scRNA-seq and CRISPR-Cas9 genome editing.

Background: Osteosarcoma (OSA), the most common primary bone malignancy, poses significant challenges due to its aggressive nature and propensity for metastasis, especially in adolescents. Mitophagy analysis can help identify new therapeutic targets and combined treatment strategies.

Methods: This study integrates single-cell sequencing (scRNA-seq) data and bulk-seq to identify mitophagy-related genes (MRGs) associated with the progression of OSA metastasis and analyze their clinical significance.

Recent Research Progress of Benzothiazole Derivative Based Fluorescent Probes for Reactive Oxygen (HO HClO) and Sulfide (HS) Recognition.

Fluorescent sensing technology has advantages such as high sensitivity, good selectivity, and easy operation. It is widely used in the environment and biomedical field and receives increasing attention from people. It is easy to modify the structure of the benzothiazole fluorophores, and adding the push-pull electronic system can regulate the optical properties of benzodiapylene molecules.

A ratiometric two-photon fluorescent probe for the quantification of nitroreductase in hypoxic neurons.

We developed a novel ratiometric two-photon fluorescent probe for the selective and precise detection of nitroreductase (NTR) in neurons. Using this probe, we found that hypoxic stimulation could up-regulate endogenous NTR levels.

P53 status combined with MRI findings for prognosis prediction of single hepatocellular carcinoma.

Object: To develop and validate a nomogram for predicting recurrence in individuals suffering single hepatocellular carcinoma (HCC) after curative hepatectomy.

Material And Methods: A retrospective analysis was conducted on 189 patients with single HCC undergoing curative resection in our center were randomized into training and validation cohorts. P53 status was determined using immunohistochemistry.

Analysis of literature-derived duplicate records in the FDA Adverse Event Reporting System (FAERS) database.

The FDA Adverse Event Reporting System (FAERS) is a large-scale repository of reports concerning adverse drug events (ADEs). The same published clinical study or report may be reviewed by multiple companies or healthcare professionals and reported separately to the FDA, leading to a significant presence of duplicate reports in FAERS. These duplicate records can result in the identification of false associations between a given drug and an ADE.

Coordination-Based Site-Specific Labeling Strategy for Electrogenerated Chemiluminescence Biosensing of Matrix Metalloproteinase 2.

Matrix metalloproteinase 2 (MMP-2) is an important biomarker for some diseases. Herein, one first-case coordination-based site-specific labeling strategy is proposed for electrogenerated chemiluminescence (ECL) biosensing of MMP-2 by employing an iridium(III) solvent complex as a signal reagent and a histidine (His)-containing peptide as a molecular recognition substrate. One ECL probe was prepared via coordination labeling of the His-containing peptide with one iridium(III) solvent complex ([(3-(2-pyridyl)benzoic acid)Ir(DMSO)Cl], Ir1-DMSO).

Association of RS1126478 (LTF) with molar-incisor and generalized periodontitis.

Objectives: LTF SNP rs1126478 (T>C) could modulate Lactoferrin function and release and has been associated with periodontal disease in different locations before, but not in America. Thus, this study aimed to assess the association between this SNP and Grade C Periodontitis (Generalized (PerioC-G) and Molar Incisor Pattern (PerioC-MIP)) and seek a relationship between its presence and LTF gingival crevicular fluid (GCF) production.

Material And Methods: Oral cells from 361 Brazilians and 375 North Americans patients (Diseased and Health Controls (PH) from both locations) were collected.

Association between residential greenness exposure and semen quality: A retrospective study in China.

Background: The association between greenness exposure and semen quality and the underlying mechanism are unclear.

Objectives: To assess the association between greenness exposure and semen quality and whether the association is mediated by air pollutant exposure.

Methods: We collected data from 10,273 men in Zhejiang, China, whose wives received assisted reproductive technology from 2015 to 2021.

A computational analysis of the oncogenic and anti-tumor immunity role of P4HA3 in human cancers.

Prolyl-4-hydroxylase subunit alpha3 (P4HA3) is a triple helical procollagen synthesis protein. The role of P4HA3 in cancer development is not well known and lacks comprehensive analyses among human cancers. This study aimed to investigate the relationship between P4HA3 expression and anti-tumor immunity and its prognostic value in pan-cancer.

Exposure to nanoplastics induces the elevation of Zn levels in cells as visualized by a Golgi apparatus-targetable ratiometric fluorescent nanosensor.

Nanoplastics are prevalent in the environment and emerging evidence suggests they can induce organ injury by activating oxidative stress. Given that both nanoplastics and Zn levels are intertwined with oxidative stress, it is crucial to investigate the influence of nanoplastics on the level of labile Zn and get a better understanding of their cytotoxicity mechanisms. At the organelle level, the Golgi apparatus plays an active role in stress responses.