Killing two birds with one stone: Siglec-15 targeting integrated bioactive glasses hydrogel for treatment of breast cancer bone metastasis.

Bone metastasis is a fatal consequence of breast cancer that occurs when patients fail to respond to conventional therapies and mainly result from a vicious cycle involving dysregulated bone homeostasis and uncontrolled tumor growth. Recent research has underscored the significance of Siglec-15, a membrane protein implicated in immunosuppression and osteoclast generation. Targeting Siglec-15 may disrupt the "vicious cycle" that causes bone metastases in patients with breast cancer.

Predicting and optimizing pure electric vehicle road noise via a locality-sensitive hashing transformer and interval analysis.

Pure electric vehicles (PEVs) lack engine noise; thus, the overall noise level within vehicle cabins are reduced. However, due to the absence of engine noise, previously overlooked noise sources are accentuated and detrimentally affect interior noise quality. Road noise is a predominant PEV noise source and significantly contributes to middle- and low-frequency interior noise levels.

Visible light-activated dye-sensitized TiO antibacterial film: A novel strategy for enhancing food safety and quality.

Antibacterial packaging holds promise in addressing food spoilage by inactivating bacteria, but current antimicrobial packaging solutions face challenges like depletion of antibacterials and concerns of antibiotic abuse. In response to these limitations of existing packaging materials, we developed a novel antibacterial packaging film by incorporating titanium dioxide (TiO)- tetra(4-carboxyphenyl) porphyrin (TcPP) conjugates into cellulose nanofibrils (CNF) films. Unlike conventional antimicrobial packaging, this film harnesses visible light energy to excite electrons from TcPP to TiO, generating reactive oxygen species (ROS) that inactivate bacteria without relying on antibiotics.

Chiral Nematic Graphene Films with a mesoporous Structure.

Ordering a crucial material like pure-graphene into the chiral nematic structure can potentially revolutionize the fields of photonics, chiral separation, and energy storage. However, the controlled fabrication of highly ordered graphene films with a long-range chiral nematic mesoporous structure is very challenging and as such, has not been achieved. Here, a chiral-template-directed chemical vapor deposition growth strategy is presented for the precise fabrication of mesoporous chiral nematic graphene films by using nanocrystalline cellulose as templates.

Cu-doped CdZnS nanocrystals: a leap forward in selective photocatalytic CO reduction to methane.

Our research has demonstrated a significant correlation between the Cu doping concentration in CdZnS and its photocatalytic performance, with CZS-2 exhibiting a 15-fold increase in methane (CH) production rate compared to pristine CZS, reaching a peak value of 519.2 μL g h. Moreover, CZS-2 demonstrates an unprecedented CH selectivity of 85.

Effects of long-term exposure to air pollutant mixture on blood pressure in typical areas of North China.

Background: Studies about the combined effects of gaseous air pollutants and particulate matters are still rare.

Objectives: This study was performed based on baseline survey of the Diverse Life-Course Cohort in the Beijing-Tianjin-Hebei (BTH) Region of North China to evaluate the association of long-term air pollutants with blood pressure and the combined effect of the air pollutants mixture among 32821 natural han population aged 20 years or above.

Methods: Three-year average exposure to air pollutants (PM, PM, PM, O, SO, NO, and CO) and PM components [black carbon (BC), ammonium (NH), nitrate (NO), sulfate (SO), and organic matter (OM)] of residential areas were calculated based on well-validated models.

Realization of chiral two-mode Lipkin-Meshkov-Glick models via acoustics.

Theare mimicked in a potential hybrid quantum system, involving two ensembles of solid-state spins coupled to a pair of interconnected surface-acoustic-wave cavities. With the assistance of dichromatic classical optical drives featuring chiral designs, it can simulate two-mode LMG-type long-range spin-spin interactions with left-right asymmetry. For applications, this unconventional LMG model can not only engineer both ensembles of collective spins into two-mode spin-squeezed states but also simulate novel quantum critical phenomena and time crystal behaviors, among others.

Sex-specific associations between total and regional Fat-to-muscle Mass ratio and cardiometabolic risk: findings from the China National Health Survey.

Background: The fat-to-muscle mass ratio (FMR), integrating the antagonistic effects of fat and muscle mass, has been suggested as a valuable indicator to assess cardiometabolic health independent of overall adiposity. However, the specific associations of total and regional FMR with cardiometabolic risk are poorly understood. We aimed to examine sex-specific associations of total and regional FMR with single and clustered cardiometabolic risk factors (CRFs).

Accelerated Fatigue Test for Electric Vehicle Reducer Based on the SVR-FDS Method.

The reducer serves as a pivotal component within the power transmission system of electric vehicles. On one hand, it bears the torque load within the power transmission system. On the other hand, it also endures the vibration load transmitted from other vehicle components.

Optimizing Cellulase- ZC529 Synergy Fermentation for Preserving Pericarp's Potential Use as Antioxidants.

pericarps (MIP) are byproducts of nut production which are rich in natural antioxidant compounds, making them an excellent source for extracting bioactive compounds. However, the antioxidant compounds in MIP are easily oxidized under natural storage conditions, resulting in significant biomass loss and resource wastage. To preserve the potential of MIP to be used as an antioxidant product, we employed cellulase and ZC529 ( ZC529) fermentation and utilized response surface methodology to optimize the fermentation parameters for mitigating the antioxidant loss.

3D chromatin structures associated with ncRNA for hyperactivation and coactivation across the entire X chromosome.

The three-dimensional (3D) organization of chromatin within the nucleus is crucial for gene regulation. However, the 3D architectural features that coordinate the activation of an entire chromosome remain largely unknown. We introduce an omics method, RNA-associated chromatin DNA-DNA interactions, that integrates RNA polymerase II (RNAPII)-mediated regulome with stochastic optical reconstruction microscopy to investigate the landscape of noncoding RNA -associated chromatin topology for gene equalization to achieve dosage compensation.

Structural characterization and screening of chemical markers of alkaloids in Aconiti lateralis radix Praeparata and its processed products by UHPLC/Q-TOF-MS/MS and GNPS combining multivariate statistical methods based on the clinic.

Rational: Aconiti Lateralis Radix Praeparata (AC) is a traditional Chinese medicine with a long history of use. However, the current research on the material basis of AC and its processed products is still not comprehensive, especially the changes in lipo-diterpenoid alkaloids (LDAs) that can be hydrolyzed into diester-diterpenoid alkaloids in AC before and after processing. This study aimed to provide material basis guidance for the clinical use of AC and its processed products by comprehensively analyzing the changes in substances between AC and its processed products.

Associations of muscle mass, strength, and quality with diabetes and the mediating role of inflammation in two National surveys from China and the United states.

Aims: The evidence for joint and independent associations of low muscle mass and low muscle strength with diabetes is limited and mixed. The study aimed to determine the associations of muscle parameters (muscle mass, strength, quality, and sarcopenia) and sarcopenia obesity with diabetes, and the previously unstudied mediating effect of inflammation.

Materials And Methods: A total of 13,420 adults from the 2023 China National Health Survey (CNHS) and 5,380 adults from the 2011-2014 National Health and Nutrition Examination Survey (NHANES) were included in this study.

The Frictional Vibration Attenuation of Rubber Utilizing a Groove on the Body.

Frictionally induced vibrations in rubber are readily triggered due to their lower stiffness and higher elasticity. This study developed a numerical model to investigate the frictional vibration of a rubber block with a groove on its side surface against an aluminum disc. The results indicate that a backside groove (GB) on the block significantly enhances vibration attenuation, with a decay time 0.

Hydrothermally Assisted Conversion of Switchgrass into Hard Carbon as Anode Materials for Sodium-Ion Batteries.

Sodium-ion batteries (SIBs) are emerging as a viable alternative to lithium-ion batteries, reducing the reliance on scarce transition metals. Converting agricultural biomass into SIB anodes can remarkably enhance sustainability in both the agriculture and battery industries. However, the complex and costly synthesis and unsatisfactory electrochemical performance of biomass-derived hard carbon have hindered its further development.

Reducing postoperative hypothermia in infants: Quality improvement in China.

Background: Unintended postoperative hypothermia in infants is associated with increased mortality and morbidity. We noted consistent hypothermia postoperatively in more than 60% of our neonatal intensive care (NICU) babies. Therefore, we set out to determine whether a targeted quality improvement (QI) project could decrease postoperative hypothermia rates in infants.

Immediate postpartum cessation of tenofovir did not increase risk of virological or clinical relapse in highly viremic pregnant mothers with chronic hepatitis B infection.

Background & Aims: Peripartum prophylaxis (PP) with tenofovir disoproxil fumarate (TDF) is the standard of care to prevent mother-to-child transmission of chronic hepatitis B (CHB) infection in mothers who are highly viremic. We investigated the maternal and infant outcomes in a large Chinese cohort of TDF-treated CHB pregnant participants.

Methods: In this prospective study, treatment-naive mothers with CHB and highly viremic (HBV DNA ≥200,000 IU/ml) but without cirrhosis were treated with TDF at 24-28 weeks of pregnancy.

Comprehensive Atlas of Alternative Splicing Reveals NSRP1 Promoting Adipogenesis through .

Alternative splicing (AS) plays a crucial role in regulating gene expression, function, and diversity. However, limited reports exist on the identification and comparison of AS in Eastern and Western pigs. Here, we analyzed 243 transcriptome data from eight tissues, integrating information on transcription factors (TFs), selection signals, splicing factors (SFs), and quantitative trait loci (QTL) to comprehensively study alternative splicing events (ASEs) in pigs.

Combined dilute alkali and milling process enhances the functionality and gut microbiota fermentability of insoluble corn fiber.

In this study, we developed a process combining dilute alkali (NaOH or NaHCO) and physical (disk milling and/or ball milling) treatments to improve the functionality and fermentability of corn fiber. The results showed that combining chemical with physical processes greatly improved the functionality and fermentability of corn fiber. Corn fiber treated with NaOH followed by disk milling (NaOH-DM-CF) had the highest water retention (19.

Preoperative T-staging of Colorectal Cancer by Dual-energy Computed Tomography: A Retrospective Study.

Background: Preoperative T-staging is essential for planning optimal treatment and care for colorectal cancer (CRC).

Objective: To evaluate the accuracy of Dual-energy CT (DECT) in preoperative T-staging of CRC.

Methods: The clinical data and DECT images of 37 patients with 39 CRC lesions were retrospectively analyzed.

Food Waste from Campus Dining Hall as a Potential Feedstock for 2,3-Butanediol Production via Non-Sterilized Fermentation.

Food waste is a major issue that is increasingly affecting our environment. More than one-third of food is wasted, resulting in over $400 billion in losses to the U.S.

Structure determines performance: isomeric Ti-MOFs for photocatalytic synthesis of hydrogen peroxide.

NH-UiO-66(Ti) and NH-MIL-125(Ti) were successfully prepared by using post-synthesis exchange (PSE) and hydrothermal methods, and then these frameworks were tested for photocatalytic hydrogen peroxide production in pure water under visible light. NH-MIL-125(Ti) exhibits superior activity compared to NH-UiO-66(Ti) due to its shorter Ti-O bond. In addition, NH-MIL-125-D (defective) demonstrates a high photocatalytic yield of hydrogen peroxide owing to the presence of defect-rich titanium rich sites.