Serologic detection of regenerating protein I alpha by time-resolved fluoroimmunoassay and its clinical value in gastric cancer.

Background: Regenerating protein I alpha (REG Iα) plays a key role in the progression of gastric cancer (GC). However, the clinical application value of serum REG Iα in GC remains largely unknown.

Methods: Serum REG Iα levels were analyzed through time-resolved fluoroimmunoassay (TRFIA) in healthy controls (HCs) and patients with benign gastric disease (BGD) and GC.

ConvXGB: A novel deep learning model to predict recurrence risk of early-stage cervical cancer following surgery using multiparametric MRI images.

Background: Accurate estimation of recurrence risk for cervical cancer plays a pivot role in making individualized treatment plans. We aimed to develop and externally validate an end-to-end deep learning model for predicting recurrence risk in cervical cancer patients following surgery by using multiparametric MRI images.

Methods: The clinicopathologic data and multiparametric MRI images of 406 cervical cancer patients from three institutions were collected.

Dipyridamole Attenuates Experimental Periodontitis by Regulating M1 Macrophage Polarization via PKA/PKG Pathways.

Aim: Periodontitis is a chronic inflammatory disease initiated by dysbiosis of the local microbial community. As a non-specific phosphodiesterase inhibitor, dipyridamole features anti-oxidant and anti-inflammatory properties. This study aimed to investigate the effects of dipyridamole in an experimental rat model of periodontitis.

Synthesis and discovery of simplified pleurotin analogs bearing tricyclic core as novel thioredoxin reductase inhibitors.

Pleurotin (1) is a benzoquinone meroterpenoid known for its wide-spectrum antitumor and antibiotic activities, notably acting as natural inhibitors of the thioredoxin reductase (TrxR). Pleurotin (1) has been chemically synthesized, but only in milligram quantities through at least 13 longest linear steps with 0.8 % overall yield due to its complex structure such as fused hexacyclic core with 8 contiguous stereocenters.

Palladium Nanosheet Enables Synergistic Electrocatalytic Dehalogenation via Direct and Indirect Electron Transfer Mechanisms.

Electrocatalytic dehalogenation is a promising method for the remediation of chlorinated organic pollutants. The dehalogenation performance is controlled by catalytic activity, and the underlying electrocatalytic dehalogenation mechanisms need to be carefully investigated for guiding the design of catalyst. Here we report the preparation of a new Pd-based catalyst with a nanosheet structure (Pd NS) by a simple wet-chemical reduction method.

Associations of Serum Homocysteine with Bone Mineral Density and Osteoporosis Incidence in Chinese Middle-Aged and Older Adults: A Retrospective Cohort Study.

Objective: This research investigated the prospective association of serum homocysteine with lumbar bone mineral density (BMD) and the risk of osteoporosis in the Chinese population.

Methods: In this cohort, 2551 Chinese individuals aged ≥50 years underwent annual health examinations. Among them, 2551, 1549, and 926 completed two, three, and more than three examinations, respectively.

Effects of Different Dietary Supplements on Swimming Performance: A Systematic Review and Network Meta-Analysis.

Background: Nutritional supplements are widely used by swimmers, but the effectiveness of various supplements and the identification of the most effective intervention require further investigation.

Purpose: This paper evaluated and compared the effectiveness of various nutrition-based interventions on swimming performance through both direct and indirect comparisons.

Methods: PubMed, Embase, Web of Science, Cochrane Library, and SPORTDiscus databases were thoroughly searched up to 4 April 2024.

Cytological, Physiological, and Transcriptome Analysis of Leaf-Yellowing Mutant in .

Color variation in plant leaves has a significant impact on their photosynthesis and plant growth. yellow-leaf mutants are ideal materials for studying the mechanisms of pigment synthesis and photosynthesis, but their mechanism of leaf variation is not clear. We systematically elucidated the intrinsic causes of leaf yellowing in the new variety 'Diecui Liuji' in terms of changes in its cell structure, pigment content, and transcript levels.

Genome-Wide Identification and Expression Analysis of Amino Acid/Auxin Permease (AAAP) Genes in Grapes ( L.) Under Abiotic Stress and During Development.

Amino acids in wine grapes function as precursors for various secondary metabolites and play a vital role in plant growth, development, and stress resistance. The amino acid/auxin permease () genes encode a large family of transporters; however, the identification and function of the gene family in grapes remain limited. Consequently, we conducted a comprehensive bioinformatics analysis of all genes in grapes, encompassing genome sequence analysis, conserved protein domain identification, chromosomal localization, phylogenetic relationship analysis, and gene expression profiling.

Metabolic and transcriptional analysis of tuber expansion in Curcuma kwangsiensis.

The tubers of Curcuma kwangsiensis are regarded as an important medicinal material in China. In C. kwangsiensis cultivation, tuber expansion is key to yield and quality, but the regulatory mechanisms are not well understood.

Exploring the Metal-Centered Reactivity of Isomeric, N-Bridged Biscyclometalated Platinum(II) Complexes.

The field of platinum chemistry is ubiquitous in the research of anticancer drugs and new OLED materials. Within the vast library of existing compounds, the majority of work focuses on complexes in the +2 and +4 oxidation states, with comparatively few examples of PtIII complexes reported without bridging ligands. PtIII complexes with metal-metal bonding can be made by mild oxidation of PtII complexes having bis(phenylpyridine) ligands.

Research progress on surface modification and coating technologies of biomedical NiTi alloys.

NiTi alloys are an important class of biomaterials with extensive clinical applications such as cardiovascular stents, orthodontic arch-wires, esophageal stents, orthopedic implants and more. However, the long-term implantation of NiTi alloys presents significant challenges due to their susceptibility to wear, corrosion and the excessive release of harmful nickel ions. These factors can severely compromise both the biocompatibility and the overall service life of the implants.

Balancing the solar irradiance needs: optimising growth in sphagnum palustre through tailored UV-B effects.

Background: The carbon sequestration potential and water retention capacity of peatlands are closely linked to the growth dynamics of Sphagnum mosses. However, few studies have focused on the response of Sphagnum moss growth dynamics to UV-B radiation, and existing research has emphasized species differences. In this study, Sphagnum palustre L.

Joint effects of depressive symptoms and triglyceride-glucose index on cardiovascular events in acute coronary syndrome patients: The mediating role of TyGi.

Objective: Our aim was to explore the joint impacts of depressive symptoms along with triglyceride-glucose index (TyGi) on major adverse cardiovascular events (MACE) in patients who have acute coronary syndrome (ACS) and investigate whether the impact of depressive symptoms on MACE is mediated through the TyGi.

Methods: This extensive cohort study included 3681 ACS patients. Depressive symptoms and TyGi were assessed at baseline, and the patients were subsequently followed for two years to monitor the occurrence of MACE.

Investigating the self-healing potential of polycystic ovary syndrome in a mouse model: Implications for offspring health.

Polycystic ovarian syndrome (PCOS) is a prevalent metabolic endocrine disorder in reproductive-aged women. This study aims to investigate the self-healing ability of PCOS and its potential impact on offspring. Methods: Female C57 BL/6J mice aged 4-5 weeks were administered letrozole (1 mg/kg/d) and a high-fat diet for 21 days to establish a PCOS model, and a control group was established.

Thrombopoietin Receptor Agonists for Thrombocytopenia in Pediatric Hematologic Malignancies.

Background: Thrombopoietin receptor agonists (TPO-RAs) have demonstrated efficacy in treating clinically significant thrombocytopenia, including chemotherapy-induced thrombocytopenia in adults. However, data regarding their safety and efficacy in pediatric, adolescents, and young adult (AYA) patients with hematologic malignancies are limited.

Methods: We retrospectively identified 15 pediatric and AYA patients aged 25 years or younger with hematologic malignancies treated with a TPO-RA at UCSF Benioff Children's Hospitals between 2015 and 2023.

Learning with noisy labels via clean aware sharpness aware minimization.

Noise label learning has attracted considerable attention owing to its ability to leverage large amounts of inexpensive and imprecise data. Sharpness aware minimization (SAM) has shown effective improvements in the generalization performance in the presence of noisy labels by introducing adversarial weight perturbations in the model parameter space. However, our experimental observations have shown that the SAM generalization bottleneck primarily stems from the difficulty of finding the correct adversarial perturbation amidst the noisy data.

METTL3-mediated mA modification regulates muscle development by promoting TM4SF1 mRNA degradation in P-body via YTHDF2.

N6-methyladenosine (mA), a well-known post-transcriptional modification, is implicated in diverse cellular and physiological processes. However, much remains unknown regarding the precise role and mechanism of mA modification on muscle development. In this study, we make observation that the levels of mA and METTL3 are markedly elevated during the differentiation phase (DM) compared to the growth phase (GM) in both C2C12 and bovine myoblasts.

In situ swelling of low-friction, high load-bearing self-bending bilayer hydrogels inspired by articular cartilage.

The articular cartilage is characterized by its gradient hierarchical structure, which exhibits excellent lubrication and robust load-bearing properties. However, its inherent difficulty in self-repair after damage presents numerous formidable challenges for cartilage repair. Inspired by the unique structure of articular cartilage, a biomimetic bilayer hydrogel composed of PAM (polyacrylamide) and PAM/SA (sodium alginate) is prepared using a two-step in-situ swelling method.

Establishment of Time-Resolved Fluorescence Immunoassay for Thyrotropin Receptor Antibodies and Clinical Application.

Thyroid-stimulating hormone receptor antibody (TRAb) is a specific marker for Graves' disease (GD) and the measurement of which can improve the accuracy of GD diagnosis. Current detection methods utilize porcine-derived polyclonal-TRAb, which is unstable and is a source of significant inter-assay variability. This study aims to establish a time-resolved fluorescence immunoassay (TRFIA) method based on stable source of recombinant human TSHR and TRAb for the detection of serum TRAb.

Comparative analysis of improved m6A sequencing based on antibody optimization for low-input samples.

The most effective method for mapping N6-methyladenosine (mA) is mA RNA immunoprecipitation sequencing (MeRIP-seq). The quality of MeRIP-seq relies on various factors, with the anti-mA antibody being a crucial determinant. However, comprehensive research on anti-mA antibody selection and optimal concentrations for different tissues has been limited.

Mechanical properties and mechanisms of soda residue and fly ash stabilized soil.

To improve the utilization rates of soda residue (SR) and fly ash (FA), reduce environmental pollution, and enhance the mechanical properties of marine clay (MC), this study proposes mixing SR, FA, and MC with cement and /or lime to prepare soda residue-fly ash stabilized soil (SRFSS). Using an orthogonal design for the proportions, the study analyzes the compaction performance, unconfined compressive strength (UCS), and shear strength of SRFSS. The influence of various factors on the mechanical properties of SRFSS was investigated through range and variance analyses.

Circular Dichroism and Interlayer Exciton Hall Effect in Transition Metal Dichalcogenides Homobilayers.

In van der Waals (vdW) architectures of transition metal dichalcogenides (TMDCs), the coupling between interlayer exciton and quantum degrees of freedom opens unprecedented opportunities for excitonic physics. Taking the MoSe homobilayer as representative, we identify that the interlayer registry defines the nature and dynamics of the lowest-energy interlayer exciton. The large layer polarization () is proved, which ensures the formation of layer-resolved interlayer excitons.

The Effects of Ultrasound on the Rehydration of Konjac Glucomannan/Soy Protein Isolate Gel and Simulation of Gas-Liquid Interface Evolution During the Rehydration Process.

Soy protein isolate (SPI) possesses potential gelling properties, making it suitable for gel-based applications. However, the gel network stability and mechanical properties of SPI are relatively poor and can be improved through modifications or by combining it with other polymers, such as Konjac Glucomannan (KGM). Combining SPI with KGM can overcome the poor gel network stability and mechanical properties of SPI, but it reduces the water-absorbing capacity of the gel network after drying, which affects the quality characteristics of plant-based protein rehydrated foods and limits the economic feasibility of soy protein foods.