Publications by authors named "Huan-Zhou Xue"
Objective: Lenvatinib was the standard first-line therapy for patients with unresectable HCC. PD-1 blockades demonstrated promising efficacy for patients with previously-treated HCC. Therefore, this study was to investigate the feasibility and tolerability of lenvatinib plus PD-1 blockades for patients with unresectable HCC retrospectively.
View Article and Find Full Text PDFAppleby operation for carcinoma of the body and tail of the pancreas.
J Cancer Res Ther
December 2018
Article Synopsis
- The study evaluates the effectiveness of the Appleby operation in treating pancreatic cancer, analyzing patient outcomes over several weeks and noting key health metrics before and after surgery.
- The operation was performed on 17 patients, resulting in significant pain relief, improved body weight, and enhanced quality of life, despite a notable complication rate of 47.1%.
- The 1-, 2-, 3-, and 5-year survival rates post-surgery were 80.4%, 54.2%, 32.5%, and 16.3%, respectively, indicating that the Appleby operation is a viable option for managing this condition.*
Article Synopsis
- The study aimed to find key genes and pathways in pancreatic ductal adenocarcinoma (PDAC) to help with early diagnosis.
- Researchers analyzed gene expression data from 34 PDAC samples and compared it with 16 healthy samples, identifying 630 upregulated and 1,002 downregulated genes.
- Important findings included specific ribosomal protein genes and spliceosome-related genes that may serve as potential molecular markers for early detection and could be crucial in the disease's progression.
Open Versus Hand-assisted Laparoscopic Total Gastric Resection With D2 Lymph Node Dissection for Adenocarcinoma: A Case-Control Study.
Surg Laparosc Endosc Percutan Tech
February 2017
Objective: A case-control study was conducted to investigate the feasibility and safety of hand-assisted laparoscopic total gastrectomy (HALTG) with D2 lymphadenectomy for gastric cancer as opposed to traditional open total gastrectomy (OTG).
Methods: One hundred fifty-four patients suffering cardia, upper, middle, or whole gastric cancer operated in our department from February 2009 to February 2012 were divided into 2 groups: the open total gastrectomy group (the OTG group) and the hand-assisted laparoscopic total gastrectomy group (the HALTG group). Operative time, estimated blood loss, number of lymph node retrieval, time to the first flatus, and postoperative hospital stay were compared between the 2 groups.
Article Synopsis
- The study investigates the roles of microRNAs miR-34a and miR-217 in hepatocellular carcinoma (HCC), focusing on their expression levels and their potential as indicators of tumor progression and patient prognosis.
- Results showed that both miR-34a and miR-217 were significantly downregulated in HCC tissues, with lower levels linked to worse clinicopathological features such as vascular invasion and advanced disease stage.
- The findings suggest that reduced expression of miR-34a and miR-217 correlates with poorer overall survival for HCC patients, indicating their potential role as tumor suppressors.
Aim: Emerging evidence has showed that long non-coding RNA (lncRNA) play an important role in the occurrence and development of various cancers. In the present study, the expression level of lincRNA-p21 was investigated in hepatocellular carcinoma (HCC), and its role in invasion of HCC was also explored.
Methods: The lincRNA-p21 levels in human HCC tumor tissue and cell lines HepG2 and SMMC-7721 were determined by real-time polymerase chain reaction.
We evaluated miR-371-5p expression in gastric cancer (GC) tissues and its influence on the expression of downstream genes, especially SOX2. MiR-371-5p expression (measured using qRT-PCR) was upregulated in GC tissues and correlated positively with TNM staging and lymph node (LN) metastasis. MiR-371-5p expression was higher in human GC cell lines (AGS, MKN-28, BGC-823, MGC-803, SGC-7901 and MKN-45) than in human normal gastric epithelial (GES-1) cells (all P < 0.
View Article and Find Full Text PDFArticle Synopsis
- SUMOylation and deSUMOylation are important processes that regulate how proteins work, with SENP proteins playing a role in removing SUMO tags from proteins, and their alteration can be linked to cancer progression.
- SENP2 specifically influences the growth of liver cancer cells (HCC) through its interaction with β-catenin, though the detailed mechanism was previously unclear.
- This study reveals that the protein WWOX is essential for the stability of β-catenin in HCC cells and is regulated by SENP2, suggesting that WWOX functions as a crucial modulator of SENP2's tumor-suppressing effects in liver cancer.
Background: Budd-Chiari syndrome (BCS) is characterized by liver sinusoidal congestion, ischemic liver cell damage, and liver portal hypertension caused by hepatic venous outflow constriction. The aim of this research was to investigate the clinicopathological features of BCS-associated hepatocellular carcinoma (HCC) and explore its surgical treatment and prognosis.
Methods: Clinical data from 38 patients with BCS-associated HCC who were surgically treated in our hospital from July 1998 to August 2010 were retrospectively analyzed.
Background & Aims: We aimed at investigating the effects of the targeted transduction of the Wtp53-pPRIME-miR30-shRNA gene into liver cancer cells, under the mediation of anti-alpha fetoprotein scFv-directed lentivirus, and the inhibitory effect of this system on liver cancer cells.
Methods: The result of infection was observed by fluorescence microscopy. Polymerase chain reaction and Western blotting were used to demonstrate the successful transduction and transcription of the Wtp53-pPRIME-miR30-shRNA-IGF1R gene.
Background/aims: Resveratrol, a polyphenolic phytochemical present in berries, grapes, and wine, has emerged as a promising chemopreventive candidate. The aim of the present study was to determine the inhibitory effect of resveratrol on vascular endothelial growth factor (VEGF) expression and angiogenesis in hepatocellular carcinoma (HCC) and to explore its mechanism.
Methodology: VEGF protein was detected by western blot, whereas VEGF mRNA expression was investigated by RT-PCR.
Matrine is the major active component of the traditional Chinese medicine Sophora flavescens, but the molecular mechanisms of matrine on tumor invasion inhibition remain unclear. The aim of this study is to elucidate the effects of matrine on invasion ability of human hepatocellular carcinoma (HCC) cells, matrix metalloproteinase-9 (MMP-9), and nuclear factor (NF)-kappa B expression. The expression activity of MMP-9 was measured by reverse transcription polymerase chain reaction, Western blot, and gelatin zymography analysis.
View Article and Find Full Text PDF[Duodenum-preserving pancreatic head resection in treating patients with chronic pancreatitis].
Zhonghua Yi Xue Za Zhi
November 2010
Objective: To evaluate the therapeutic efficacy of duodenum-preserving pancreatic head resection (DPPHR) for severe chronic pancreatitis (CP).
Methods: From February 2004 to March 2010, duodenum-preserving resection of pancreatic head was performed in 21 patients with severe CP. A "modified-DPPHR" was carried out in 14 patients of them and a "Frey's DPPHR" in the other 7 patients.
Background: Few reports have evaluated the efficacy of re-operation for relapse after initial surgery for hepatocellular carcinoma (HCC) with bile duct thrombosis (BDT). The aim of this study was to investigate the efficacy of initial surgery and subsequent re-operation for HCC with BDT, and their effects on prognosis.
Methods: The clinical data of 880 patients with HCC, including 28 patients with BDT, who underwent radical hepatectomy between 1998 and 2008 in our hospital, were reviewed.
Objective: To observe the expression of antibodies of cytokeratin 19 and 20 in lymph node micrometastasis in patients with extrahepatic cholangiocarcinoma (EHCC), evaluate the prognostic significance of lymph node (LN) micrometastasis and study the correlation between lymph node micrometastasis and clinicopathological features, CA19-9 and CEA.
Methods: A total of 279 lymph nodes was intra-operatively collected from 59 EHCC patients and routine histological examination performed. Immunohistochemical staining was performed on all samples by the murine antibodies of anti-CK19 and anti-CK20 respectively.
Objectives: To investigate the expression of Survivin in patients with extrahepatic cholangiocarcinoma (EHCC) and its relationship with clinicopathological features of EHCC, and the correlation between the expression of Survivin and lymph node micrometastasis, tumor markers, and the prognosis of EHCC.
Methods: The expression of Survivin protein in paraffin-embedded specimens of 59 patients with EHCC and their 20 para-carcinoma tissues were evaluated by S-P method of immunohistochemical staining. The correlation between the expression of Survivin and the lymph node micrometastasis, clinicopathological features of EHCC and the prognosis of EHCC were analyzed.
Objective: To evaluate the therapeutic efficacy of interposition of graft meso-cavo-atri shunt (MCAS) for the treatment of Budd-Chiari syndrome (BCS) with occlusion of both inferior cava vena (ICV) and hepatic veins (HVs).
Methods: 51 BCS patients with combined occlusion of ICV and HVs, 30 males and 20 females, aged 18-45, underwent MCAS. A 16-18 mm ring-reinforced graft (main graft) was anastomosed firstly to the side of ICV with continuous 5/0 vascular suture, then to the side of the right atrium with continuous 5/0 vascular suture.
Background & Objective: The excision rate is low for the intermediate and advanced pancreatic head carcinoma. Comprehensive treatment is the main method to prolong patient's life. The objective of this study was to discuss the effect of intraoperative and postoperative radiotherapy on intermediate and advanced pancreatic head carcinoma.
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