Publications by authors named "Huan-Yang Zhang"
Article Synopsis
- Glutamate dehydrogenase 1 (GLUD1) expression decreases in hepatocellular carcinoma (HCC) tumors, correlating with a poorer prognosis for patients.
- Silencing GLUD1 promotes HCC cell growth and migration due to increased interleukin-32 via AKT activation, showing a mechanism for hepatocarcinogenesis.
- LASP1 and SYVN1 play crucial roles in promoting GLUD1 degradation, particularly in HBV-related HCC, thereby inhibiting GLUD1's tumor-suppressing functions.
Purpose: As a vital component of the hepatitis B virus (HBV) nucleocapsid, HBV core protein (HBC) contributes to hepatocarcinogenesis. Here, we aimed to assess the effects of RANGAP1 and KDM2A on tumorigenesis induced by HBC.
Methods: Co-immunoprecipitation (Co-IP) combined with mass spectrometry were utilized to identify the proteins with the capacity to interact with HBC.