Publications by authors named "Huan-Rong Bai"
Article Synopsis
- Mixed lineage leukemia (MLL) gene rearrangements are linked to acute leukemia, with menin playing a key role as an oncogenic cofactor for MLL fusion proteins.
- The interaction between menin and the MLL amino terminal sequences is essential for the cancer-causing effects of these proteins.
- Recent advancements in structural biology have led to the development of specific inhibitors targeting the menin-MLL interaction, with discussions on future research directions and the challenges faced in this area.
