Publications by authors named "Huan-Huan Liang"
Aim: To investigate the change of ocular surface and corneal nerve and their correlation in patients suffering from type 2 diabetes mellitus under different degrees of retinopathy.
Methods: Totally 129 type 2 diabetes mellitus patients (257 eyes) were included. They were divided into three groups: no diabetic retinopathy (NDR) group (33 cases, 66 eyes), non-proliferative diabetic retinopathy (NPDR) group (32 cases, 64 eyes), and proliferative diabetic retinopathy (PDR) group (34 cases, 67 eyes).
Article Synopsis
- Acute promyelocytic leukemia (APL) is primarily driven by the PML-RARA fusion gene resulting from a specific chromosomal translocation (t(15;17)), but some cases don't show this fusion using conventional tests.
- Next-generation sequencing of 111 pediatric APL patients revealed additional genetic rearrangements and fusion genes, suggesting alternative pathways to APL development and highlighting the complexity of the disease beyond the PML-RARA fusion.
- The presence of RARA rearrangements is associated with better survival outcomes in APL patients, while mutations in genes like WT1 and NPM1 are linked to both primary and relapsed stages of the disease, indicating their role in disease progression.
[Expression of zinc finger protein X-linked in childhood B lineage acute lymphoblastic leukemia].
Zhongguo Dang Dai Er Ke Za Zhi
July 2013
Objective: To study the expression of zinc finger protein X-linked (ZFX) in bone marrow mononuclear cells (BMMCs) of children with B lineage acute lymphoblastic leukemia (B-ALL) and its relationship with prognosis.
Methods: The expression of ZFX in human leukemia cell lines (REH, HL-60, NB(4) and K562) was measured by Western blot. ZFX gene was cloned by PCR from one patient and DNA sequencing technology was used to confirm it.