Noninvasive early identification of durable clinical benefit from immune checkpoint inhibition: a prospective multicenter study (NCT04566432).

Immune checkpoint inhibitors (ICIs) have changed the treatment landscape for patients with non-small cell lung cancer (NSCLC). In spite of durable responses in some patients, many patients develop early disease progression during the ICI treatment. Thus, early identification of patients with no durable benefit would facilitate the clinical decision for these patients.

STK39-mediated amplification of γ-H2A.X promotes homologous recombination and contributes to PARP inhibitor resistance.

The phosphorylation of histone H2A.X into γH2A.X is a crucial early event in the DNA damage response, marking DNA damage sites and initiating repair processes.

Fance deficiency impaired DNA damage repair of prospermatogonia and altered the repair dynamics of spermatocytes.

Background: Non-obstructive azoospermia (NOA) is the most severe form of male infertility and affects approximately 1% of men worldwide. Fanconi anemia (FA) genes were known for their essential role in DNA repair and growing evidence showed the crucial role of FA pathway in NOA. However, the underlying mechanisms for Fance deficiency lead to a serious deficit and delayed maturation of male germ cells remain unclear.

Femtosecond laser composite manufactured double-bionic micro-nano structure for efficient photothermal anti-icing/deicing.

The solar anti-icing/deicing (SADI) strategy represents an environmentally friendly approach for removing ice efficiently. However, the extensive use of photothermal materials could negatively impact financial performance. Therefore, enhancing light utilization efficiency, especially by optimizing the design of a structure with a low content of photothermal materials, has rapidly become a focal point of research.

Preparation of κ-carrageenan oligosaccharides by photocatalytic degradation: Structural characterization and antioxidant activity.

To accurately, efficiently, and environmentally prepare carrageenan oligosaccharides, we have developed a method that uses HO and TiO as catalysts for the photodegradation of κ-carrageenan (KC). The photodegradation of KC was monitored using various amounts of TiO and HO and different concentrations of KC via HPLC and it could decrease the average molecular weight of KC into 1.6 kDa within 2 h.

Spontaneous Separation of Immiscible Organic Droplets on Asymmetric Wedge Channels with Hierarchical Microchannels.

Spontaneous separation of immiscible organic droplets has substantial research implications for environmental protection and resource regeneration. Compared to the widely explored separation of oil-water mixtures, there are fewer reports on separating mixed organic droplets on open surfaces due to the low surface tension differences. Efficient separation of mixed organic liquids by exploiting the rapid spontaneous transport of droplets on open surfaces remains a challenge.

L.-Like Periodic Micronano Structured Superhydrophobic Surface with Ultralow Ice Adhesion for Efficient Anti-Icing/Deicing.

Wind turbine blades are often covered with ice and snow, which inevitably reduces their power generation efficiency and lifetime. Recently, a superhydrophobic surface has attracted widespread attention due to its potential values in anti-icing/deicing. However, the superhydrophobic surface can easily transition from Cassie-Baxter to Wenzel at low temperature, limiting its wide applications.

Reduced FANCE Confers Genomic Instability and Malignant Behavior by Regulating Cell Cycle Progression in Endometrial Cancer.

Fanconi anemia complementation group E (FANCE) is a subunit of fanconi anemia (FA) pathway and plays a key role in repairing DNA interstrand cross-links (ICLs) damage. We investigate detailed functions and mechanisms of FANCE in endometrial cancer (EC). FANCE protein and RNA expression in EC and non-cancerous tissues were detected by Western blotting (WB), immunohistochemistry (IHC), and real-time polymerase chain reaction (RT-PCR) assays.

Excessive Sedentary Time Is Associated with Cognitive Decline in Older Patients with Minor Ischemic Stroke.

Background: Cognitive impairment is commonly seen after acute ischemic stroke (AIS). Sedentary behaviors increase the risk of dementia among community dwelling population.

Objective: This study aims to investigate the association of sedentary behaviors with poststroke cognitive impairment among older adults with minor AIS.

Extreme learning machine and genetic algorithm in quantitative analysis of sulfur hexafluoride by infrared spectroscopy: erratum.

This erratum reports corrections for the original publication, Appl. Opt.61, 2834 (2022)APOPAI0003-693510.

Fance deficiency inhibits primordial germ cell proliferation associated with transcription-replication conflicts accumulate and DNA repair defects.

Fanconi anemia (FA) gene mutations are critical components in the genetic etiology of premature ovarian insufficiency (POI). Fance mice detected meiotic arrest of primordial germ cells (PGCs) as early as embryonic day (E) 13.5 and exhibited decreased ovarian reserve after birth.

Fracture Resistance Biomechanisms of Walnut Shell with High-Strength and Toughening.

Walnut shell is lightweight material with high-strength and toughening characteristics, but it is different from other nut shells' microstructure with two or three short sclerotic cell layers and long bundle fibers. It is essential to explore the fracture resistance biomechanism of lightweight walnut shell and how to prevent damage of bionic structure. In this study, it is found that the asymmetric mass center and geometric center dissipated impact energy to the whole shell without loading concentration in the loading area.

Rapamycin reverses ferroptosis by increasing autophagy in MPTP/MPP-induced models of Parkinson's disease.

Parkinson's disease is a neurodegenerative disorder, and ferroptosis plays a significant role in the pathological mechanism underlying Parkinson's disease. Rapamycin, an autophagy inducer, has been shown to have neuroprotective effects in Parkinson's disease. However, the link between rapamycin and ferroptosis in Parkinson's disease is not entirely clear.

Histological and transcriptomic analysis of Fance-deficient PGCs reveal the possible mechanisms of their depletion.

In Brief: Fanconi anemia results in subfertility and germ cell deficiency in women. We present histological and RNA-seq analysis of Fance-deficient primordial germ cells to explore the possible mechanisms of their progressive depletion.

Abstract: Primordial germ cells (PGCs) development is a subtle and complex regulatory process.

Gas sensing performance of InO nanostructures: A mini review.

Effective detection of toxic and hazardous gases is crucial for ensuring human safety, and high-performance metal oxide-based gas sensors play an important role in achieving this goal. InO is a widely used n-type metal oxide in gas sensors, and various InO nanostructures have been synthesized for detecting small gas molecules. In this review, we provide a brief summary of current research on InO-based gas sensors.

Effect of on Antioxidant and Anti-Ageing Activities in .

As an acidic polysaccharide, the formation of (HA) is typically (SH) for knee repair, oral treatment, skincare and as a food additive. Nevertheless, little information is available on the anti-ageing activity of SH as a food additive. Therefore, we treated with SH, then inferred the anti-aging activity of SH by examining the lifespan physiological indicators and senescence-associated gene expression.

Artemisinin exerts a protective effect in the MPTP mouse model of Parkinson's disease by inhibiting microglial activation via the TLR4/Myd88/NF-KB pathway.

Aims: We performed cell and animal experiments to explore the therapeutic effect of artemisinin on Parkinson's disease (PD) and the TLR4/Myd88 signaling pathway.

Methods: C57 mice were randomly divided into the blank, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced and artemisinin-treated groups. Clinical symptoms, the number of dopaminergic (DAergic) neurons in the substantia nigra, and microglial cell activation were compared among the three groups.

Pan-cancer analysis of the prognostic and immunological role of Fanconi anemia complementation group E.

Fanconi anemia (FA) genes contribute to tumorigenesis by regulating DNA repair. Despite its importance for assembly and functionality of the FA core complex, no pan-cancer analysis of was performed. We aimed to provide a comprehensive understanding of the role of in cancers.

Ceramides from Sea Red Rice Bran Improve Health Indicators and Increase Stress Resistance of through Insulin/IGF-1 Signaling (IIS) Pathway and JNK-1.

The antiaging effects of sea red rice bran , a new saline-tolerant sea rice byproduct containing high levels of ceramides (Cers), remain unknown. This study aimed to explore the antiaging effects exerted by Cers from sea red rice bran on , assess its health indicators as well as tolerance, and then reveal the mechanism of action of Cers in prolonging the mean life span through genetic studies. The results indicated that the mean life span of Cers-treated were dose-dependent in the range of 0.

Outcomes of High-Dose Stereotactic Ablative Radiotherapy to All/Multiple Sites for Oligometastatic Renal Cell Cancer Patients.

Background: Stereotactic ablative body radiotherapy (SABR) is one of the treatment options for oligometastatic renal cell carcinoma (RCC) but is limited by a lack of data to evaluate high-dose SABR to all/multiple sites.

Objective: This study retrospectively investigated the efficacy and prognostic factors of high-dose SABR for oligometastatic RCC patients.

Design, Setting, And Participants: Patients with oligometastatic RCC on systemic therapy were retrospectively collected.

FANCD2 promotes the malignant behavior of endometrial cancer cells and its prognostic value.

Defective DNA damage repair is a key mechanism affecting tumor susceptibility, treatment response, and survival outcome of endometrial cancer (EC). Fanconi anemia complementation group D2 (FANCD2) is the core component of the Fanconi anemia repair pathway. To explore the function of FANCD2 in EC, we examined the expression of FANCD2 in human specimens and databases, and discussed the possible mechanism of carcinogenesis by in vitro assays.

The Proportion of Vδ1T Cells in Peripheral Blood Correlated with Prognosis of Sepsis.

Background: Sepsis is a serious condition with a high mortality rate, and septic patients often have organ dysfunction, low tissue perfusion and hypoxia, lactic acidosis, oliguria, or functional brain changes.

Objective: To observe the number and the function of Vδ1T cells in peripheral blood of septic patients, to analyze the clinical significance of detecting Vδ1T cells, and to clarify the correlation of their presence with the prognosis of sepsis.

Methods: The basic data of the septic patients were recorded at admission.

High-Performance Visible-Near-Infrared Single-Walled Carbon Nanotube Photodetectors via Interfacial Charge-Transfer-Induced Improvement by Surface Doping.

Single-walled carbon nanotubes (SWCNTs) are considered to be promising candidates for next-generation near-infrared (NIR) photodetectors due to their extraordinary electrical and optical properties. However, the low separation efficiency of photogenerated carriers limits the full utilization of the potential of pristine SWCNTs as photoactive materials. Herein, we report a novel high-performance visible-NIR SWCNT-based photodetector via interfacial charge-transfer-induced improvement by Au nanoparticle (AuNP) surface doping.