Daily dosing frequency as a determinant of clozapine concentration-to-dose ratio: Data from a therapeutic drug monitoring service (2019-2022).

Background And Aims: Daily dosing frequency is an important factor influencing the plasma concentration of clozapine. This study investigated pharmacokinetic parameters in different daily dosing frequency regimens of clozapine in a naturalistic therapeutic drug monitoring sample to establish the necessary clozapine dosage to achieve plasma levels of 350-600 ng/mL in the Chinese population.

Study Design: A single-center, retrospective, cross-sectional study was conducted at Xi'an Mental Health Center in China, where data on clozapine-treated patients between 2019 and 2022 were collected.

Electrochemical chiral recognition of tryptophan enantiomers by using chiral polyaniline and β-CD-MOF.

Chiral detection of tryptophan (Trp) isomers is of vital importance and the introduction of efficient, stable and sensitive enantioselective recognition technology is in high demand in the fields of medicine, food and life science. Herein, a facile and sensitive electrochemical probe for the chiral recognition of Trp enantiomers by using chiral polyaniline (D-PANI) and β-CD-MOF is presented. The structure and electrochemical performance of the designed sensor (GCE/β-CD-MOF/D-PANI) were characterized FT-IR, SEM, TEM, EIS, CV and DPV methods.

Alkaline capacity decay induced vacancy-rich LDH for high-performance magnesium ions hybrid supercapacitor.

Transition metal double hydroxides (LDHs) are among the most promising electrode materials in electrochemical energy storage. In this study, we synthesized electrodeposited nickel-cobalt layered double hydroxide (NiCo-LDH) to investigate the significant capacity gap in LDHs at different scan rates in an alkaline electrolyte. Experimental results demonstrate that the degradation of capacity at high scan rates is primarily attributed to the slow ion diffusion and the decreased reversibility of active metal ions.

Consumer Preferences and Willingness to Pay for High-Quality Vegetable Oils: A Cross-Sectional Analysis of Chinese Residents.

The consumption of edible vegetable oil is an important source of essential fatty acids and vitamin E for the human body. Guiding residents to consume scientifically and reasonably control the intake of edible oils is an important part of promoting the construction of a healthy China. Currently, Chinese residents have an insufficient understanding of the scientific consumption of edible oils, leading to an intake exceeding the dietary recommendations, resulting in excessive fat intake and increasing the risk of chronic diseases such as obesity and cardiovascular diseases.

Inhibition of γ-secretase/Notch pathway as a potential therapy for reversing cancer drug resistance.

The mechanism of tumor drug resistance is complex and may involve stem cell maintenance, epithelial-mesenchymal transition, the activation of survival signaling pathways, transporter protein expression, and tumor microenvironment remodeling, all of which are linked to γ-secretase/Notch signaling. Increasing evidence has shown that the activation of the γ-secretase/Notch pathway is a key driver of cancer progression and drug resistance development and that γ-secretase inhibitors (GSIs) may be the most promising agents for reversing chemotherapy resistance of tumors by targeting the γ-secretase/Notch pathway. Here, we systematically summarize the roles in supporting γ-secretase/Notch activation-associated transformation of cancer cells into cancer stem cells, promotion of the EMT process, PI3K/Akt, MEK/ERK and NF-κB activation, enhancement of ABC transporter protein expression, and TME alteration in mediating tumor drug resistance.

A retrospective study of clozapine and norclozapine concentration in patients with schizophrenia: Data from the Therapeutic Drug Monitoring Service, 2019-2022.

Objective: The aim of this research was to assess the therapeutic drug monitoring (TDM) of clozapine (CLO) and norclozapine (NCLO).

Methods: TDM results of CLO and NCLO in patients obtained from the Xi'an Mental Health Center were retrospectively analyzed.

Results: TDM of CLO and NCLO was typically conducted only once in the majority of patients, particularly those receiving outpatient care.

Successful treatment of urticarial vasculitis with omalizumab in children: a case series.

Urticarial vasculitis (UV) is a small vessel leucocytoclastic vasculitis, which often needs to be distinguished from urticaria and other dermatoses. Treatment of UV in children is challenging because of the unsatisfying efficacy of antihistamines and the safety concern of long-term systemic corticosteroids or immunosuppressive agents. As a classic biological agent widely used in chronic spontaneous urticaria, omalizumab might also be a potential therapeutic option in the treatment of children with UV.

Fatal multisystem inflammatory syndrome in a 78-year-old adult after severe COVID-19 pneumonia during 2022 Omicron variant epidemic in Shanghai, China.

Multisystem inflammatory syndrome adult type (MIS-A) is a rare type of post-acute COVID-19 syndrome which more frequently occurred in younger population. Here we present a 78-year-old Chinese female, the oldest case reported, diagnosed with MIS-A who had severe SARS-CoV-2 infection. She was diagnosed with severe COVID-19 and experienced an unexpected sudden hemodynamic collapse in the recovery period within three weeks.

MXene-based wireless facemask enabled wearable breath acetone detection for lipid metabolic monitoring.

Breath acetone (BrAC) detection presents a promising scheme for noninvasive monitoring of metabolic health due to its close correlation to diets and exercise-regulated lipolysis. Herein, we report a TiCT MXene-based wireless facemask for on-body BrAC detection and real-time tracking of lipid metabolism, where TiCT MXene serves as a versatile nanoplatform for not only acetone detection but also breath interference filtration. The incorporation of in situ grown TiO and short peptides with TiCT MXene further improves the acetone sensitivity and selectivity, while TiO-MXene interfaces facilitate light-assisted response calibration.

Novel pathogenic variants in gene in three Chinese piebaldism patients.

Background: Piebaldism is a rare autosomal dominant disease, and roughly 75% patients had gene mutations. Up to date, approximately 90 mutations causing piebaldism were reported.

Methods: To identify gene mutations in three pediatric piebaldism patients from different families and explore the genotype-phenotype correlation, peripheral blood DNA were collected from probands and their parents.

Effects of Age, Sex, and Comedication on the Plasma Concentrations of Olanzapine in Chinese Patients With Schizophrenia Based on Therapeutic Drug Monitoring Data.

Background: Olanzapine (OLA) is an atypical second-generation antipsychotic that exhibits significant pharmacokinetic variability. We retrospectively investigated the effects of age, sex, and specific comedications on OLA pharmacokinetics in Chinese patients with schizophrenia.

Methods: Data on sex, age, and OLA dosage and steady-state plasma concentrations of 386 patients with schizophrenia (who have received OLA or a comedication of OLA with a psychotherapeutic drug) were collected and analyzed.

Effects of quadratus lumborum block on perioperative multimodal analgesia and postoperative outcomes in patients undergoing radical prostatectomy.

Background: This study aimed to investigate the effects of ultrasound-guided quadratus lumborum block (QLB) on perioperative multimodal analgesia and postoperative outcomes in patients undergoing radical prostatectomy.

Methods: A total of 80 patients undergoing radical prostatectomy were randomly divided into two groups: general anaesthesia with QLB (QLB group; n = 40) and general anaesthesia with sham QLB (normal saline [NS] group; n = 40). QLB or sham QLB was performed before the induction of anaesthesia.

ALICE: a hybrid AI paradigm with enhanced connectivity and cybersecurity for a serendipitous encounter with circulating hybrid cells.

A fully automated and accurate assay of rare cell phenotypes in densely-packed fluorescently-labeled liquid biopsy images remains elusive. Employing a hybrid artificial intelligence (AI) paradigm that combines traditional rule-based morphological manipulations with modern statistical machine learning, we deployed a next generation software, ALICE (Automated Liquid Biopsy Cell Enumerator) to identify and enumerate minute amounts of tumor cell phenotypes bestrewed in massive populations of leukocytes. As a code designed for futurity, ALICE is armed with internet of things (IOT) connectivity to promote pedagogy and continuing education and also, an advanced cybersecurity system to safeguard against digital attacks from malicious data tampering.

Facet-dependent decoration of TiO mesocrystals on TiO microcrystals for enhanced photoactivity.

Bottom-up constructions of hierarchical TiO are effective to enhance their photoactivity towards degradations of organic pollutants. Thanks to highly active facets, {001} exposed anatase TiO microcrystals attract much attention in photocatalysis; yet their efficiency is limited by the large crystal size. Herein, we report a facile solution approach to deposit anatase TiO mesocrystals only on {101} facets of anatase TiO microcrystals.

Sheet-on-belt branched TiO(B)/rGO powders with enhanced photocatalytic activity.

TiO(B) is usually adopted to construct phase junctions with anatase TiO for applications in photocatalysis to facilitate charge separation; its intrinsic photocatalytic activity, especially when in the form of one- or three-dimensional nanostructures, has been rarely reported. In this study, a sheet-on-belt branched TiO(B) powder was synthesized with the simultaneous incorporation of reduced graphene oxide (rGO). The monophase, hierarchically nanostructured TiO(B) exhibited a reaction rate constant 1.

Ultrasonic irradiation of low intensity with a mode of sweeping frequency enhances the membrane permeability and cell growth rate of Candida tropicalis.

Here we report the enhancement of both cellular permeability and cell growth rate of Candida tropicalis after treatment with the ultrasonic irradiation of low intensity using a mode of sweeping frequency (UILS) generated by a self-developed ultrasonic device in our lab. After the ultrasonic treatment, remarkable biomass enhancement of the yeast was observed; the hyphae became significantly longer; the seeped cellular protein and nucleic acid from the yeast increased and the cellular Ca content became lower. Illumina transcriptome sequencing showed that the ultrasonic treatment affected the expression of genes involved in diverse cellular components, biological processes and molecular functions.

Effects of ammonia exposure on carcass traits and fatty acid composition of broiler meat.

We aimed to study the effects of ammonia on carcass traits, organ indices and fatty acid composition of broilers. Four hundred 21-d-old male Arbor Acres broilers with initial weight 563.52 ± 2.