Publications by authors named "Huan X Meng"
Objective: To investigate various factors affecting the clinical outcome of nonsurgical periodontal treatment and evaluate the treatment effects of adjunctive amoxicillin and metronidazole (AMX + MET) in patients with generalised aggressive periodontitis (GAgP).
Methods: Forty-two patients with GAgP were recruited and randomly assigned to three groups: scaling and root planing (SRP) only, AMX + MET after SRP, and AMX + MET during SRP. The patients were assessed every 2 months post-therapy.
Article Synopsis
- The study aimed to explore how the CYP1A1 rs1048943 genetic variant affects outcomes of nonsurgical periodontal therapy in patients with generalized aggressive periodontitis.
- 224 patients were genotyped and 125 underwent treatment, with clinical measurements taken at baseline, 3 months, and up to 3 years post-treatment.
- Results showed that G allele carriers had worse clinical outcomes like deeper probing depths and greater tooth loss compared to non-carriers, suggesting that this genetic variant may significantly impact treatment success.
Objective: To evaluate whether the periodontal status was affected in patients with stage IV/grade C periodontitis after orthodontic treatment.
Methods: Twenty-four patients with stage IV/grade C periodontitis who received combined periodontal and orthodontic treatment were included in this study. Probing depth (PD), bleeding on probing (BOP) and percentage of relative bone height (RBH%) were measured and calculated.
Objective: To explore associations between mean discrepancy values for the first and second molars (MDVFSs) and generalised aggressive periodontitis (GAgP) using hospital-based periodontal examination records from a large Chinese population.
Methods: Data from consecutive patients diagnosed as having chronic periodontitis (CP, n = 51,849) and GAgP (n = 2,706) were included. Patient ages, gender, smoking status, mean full-mouth probing depth (PD), and mean full-mouth attachment loss (AL), as well as MDVFSs for PD and AL, were extracted.
Background: The aim of the present study is to evaluate the serum receptor activator of nuclear factor-κβ ligand (RANKL)/osteoprotegerin (OPG) system in patients with chronic periodontitis (CP) and type 2 diabetes mellitus (T2DM) and its changes after periodontal intervention.
Methods: Thirty-five patients with CP + T2DM, 35 systemically healthy patients with CP, and 35 healthy controls were enrolled, and serum levels of RANKL and OPG were measured at baseline. Then the CP + T2DM group was divided into a well-controlled subgroup and a poorly controlled subgroup according to their hemoglobin A1c (HbA1c), and initial periodontal therapy was performed.
Article Synopsis
- - This study examines the discomfort felt by patients during non-surgical periodontal therapy when local anaesthesia (LA) is either provided or refused.
- - Out of 60 participants, those who received LA reported significantly less discomfort and dental anxiety compared to those who did not, highlighting the importance of pain management.
- - The findings suggest that dentists should consider alternative pain control methods for patients who decline LA, as this can influence their overall satisfaction with the treatment.
Treatment of generalised aggressive periodontitis: a 4-year follow-up case report.
Chin J Dent Res
September 2012
Aggressive periodontitis comprises a group of rare, often severe, rapidly progressive forms of periodontitis mostly characterised by an early age of clinical manifestation and a distinctive tendency for cases to aggregate in families. This case report presents a 16-year-old female patient with clinical and radiographic evidence of severe attachment loss, whose mother was also a patient with severe periodontal destruction. The girl was diagnosed with generalised aggressive periodontitis and received full-mouth scaling and root planing, bone graft surgeries and guided tissue regeneration on intrabony defects mesial of the mandibular first molars.
View Article and Find Full Text PDFHereditary gingival fibromatosis (HGF) is a rare condition characterised by severe gingival hyperplasia, which could result in serious aesthetic and emotional problems and functional impairment. Here the present authors report a case of a 28-year-old female patient with generalised severe gingival enlargement covering almost all of the teeth and diagnosed as HGF. Her family history was of significance, since her father and 3-year-old daughter suffered from the same symptoms.
View Article and Find Full Text PDFCyclic neutropenia is a rare haematologic disorder. This case report presents a 6-year-old girl who was referred in order to treat gingival recession, and was finally diagnosed as having cyclic neutropenia based on an oral examination, complete blood counts and a sternal puncture bone marrow test. The patient received systematic granulocyte colony-stimulating factor therapy, full-mouth scaling and root planing and was followed up for 4 years.
View Article and Find Full Text PDFObjective: To examine changes of four proinflammatory proteins in whole saliva in the early stage of plaque-induced experimental gingivitis.
Methods: Eleven young male volunteers were recruited following the cessation of all oral hygiene measures for a period of 21 days. The levels of Interleukin-6 (IL-6), Interleukin-1ß (IL-1ß), calprotectin in saliva were determined with enzyme linked immunosorbent assay.
Objective: to examine the possible association of CCR2-V64I and MCP-1-2518A/G polymorphisms with generalised aggressive periodontitis (GAgP) in the Chinese population.
Methods: one hundred and twenty-four GAgP patients and 94 healthy subjects were included in the study. A peripheral blood sample was obtained from each subject and genomic DNA was isolated.
Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can activate apoptotic pathways associated with maintenance of genome integrity. This perspective focuses on the pathways linking DNA methyltransferases and methyl-CpG binding proteins to apoptosis, and includes new bioinformatic analyses to characterize the evolutionary origin of two G/T mismatch-specific thymine DNA glycosylases, MBD4 and TDG.
View Article and Find Full Text PDF[FBAT analysis of polymorphisms of vitamin D receptor (Taq I and Fok I) in aggressive periodontitis families].
Beijing Da Xue Xue Bao Yi Xue Ban
February 2010
Article Synopsis
- This study explored the link between specific genetic variations (polymorphisms) of the vitamin D receptor gene (Taq I and Fok I) and aggressive periodontitis (AgP) using family-based association testing (FBAT).
- A total of 93 families were examined, revealing that allele T was significantly more common than allele t, and fathers had a higher frequency of allele t compared to mothers.
- Ultimately, the findings indicated no significant correlation between these vitamin D receptor gene polymorphisms and the occurrence of aggressive periodontitis in the studied Chinese families.
[Relationship between herpesviruses and periodontal pathogenic bacteria in subgingival plaque].
Beijing Da Xue Xue Bao Yi Xue Ban
June 2008
Objective: To evaluate the prevalence rates of human cytomegalovirus(HCMV) and Epstein-Barr virus-1(EBV-1) in subgingival plaque and analyze the relationship between herpesviruses, periodontal pathogenic bacteria and periodontal clinical parameters in Chinese patients with aggressive periodontitis(AgP).
Methods: A total of one hundred and twenty subgingival plaque samples were collected from 89 AgP patients and 31 healthy subjects. HCMV and EBV-1 were detected using nested polymerase chain reaction(PCR).
Background: It has been suggested that aggressive periodontitis (AgP) has a genetic basis, but this theory has not been confirmed. The intent of this investigation was to study whether specific interleukin (IL)-1 genotypes and/or alleles could be used to predict susceptibility to generalized AgP (GAgP) in Chinese.
Methods: The GAgP group consisted of 122 patients, and the control group included 95 healthy subjects.