Fe/Cu-AuNP nanocomposites as enzyme-like catalysts to modulate the tumor microenvironment for enhanced synergistic cancer therapy.

The intensive investigation of chemodynamic therapy (CDT) for tumor eradication revealed that the therapeutic effects of this ROS-mediated therapy are limited by endogenous reductants and inefficient Fenton-like reactions. In this study, we developed a new Fe/Cu-AuNP-PEG nanocomposite to enhance CDT and provide a synergistic treatment for tumors. The Fe/Cu-AuNP-PEG nanocomposite demonstrated effective ˙OH production and high photothermal conversion efficiency under 808 nm illumination, which promoted the ˙OH production, thereby enhancing the CDT efficacy and exhibiting a synergistic treatment for cancer.

Universal Control for Micromotor Swarms with a Hybrid Sonoelectrode.

Enabled by active motion of microrobots, conventional biological detection and chemical analyses limited by passive diffusion can be significantly enhanced with fast testing speed and unique sensitiveness. However, controlled release and precise enrichment of microrobot swarms are still difficult to accomplish and thus prohibit them away from practical applications. Here, an efficient and versatile strategy utilizing a needle-shaped hybrid sonoelectrode to disperse and aggregate distinct micromotors is presented, remarkably accelerating mass transfer and enhancing the signal intensity.