Recurrent Enteritis and Intestinal Obstruction in a Patient with Chronic Mucocutaneous Candidiasis due to STAT1 Gain-of-Function Mutation.

We presented a case of chronic mucocutaneous candidiasis (CMC) due to STAT1 GOF mutation with recurrent enteritis and intestinal obstruction. A 33-year-old woman complained of recurrent oral erosion and finger (toe) nails damage for over 30 years. Candida albicans were cultured from the oral mucosa and nails.

Depth-of-Discharge Dependent Capacity Decay Induced by the Accumulation of Oxidized Lattice Oxygen in Li-Rich Layered Oxide Cathode.

More and more basic practical application scenarios have been gradually ignored/disregarded, in fundamental research on rechargeable batteries, e.g. assessing cycle life under various depths-of-discharge (DODs).

Effectively Enhancing the Physiological Activity and Sensory Quality of Whole Calamondin Puree via Yeast Fermentation.

To explore the feasibility of pure yeast fermentation in whole Calamondin puree (FWCP) for the utilization of the whole fruit, yeasts were isolated from naturally fermented Calamondin, and their fermentation characteristics were evaluated. The results indicated that all yeasts were able to ferment FWCP, reducing the sour taste by degrading citric acid, increasing the contents of nutrients (such as phenols and limonins) and volatile compounds, and enhancing the antioxidant activity and inhibition of α-glucosidase activity ( < 0.05).

Age-related decline in CD8 tissue resident memory T cells compromises antitumor immunity.

Aging compromises antitumor immunity, but the underlying mechanisms remain elusive. Here, we report that aging impairs the generation of CD8 tissue resident memory T (T) cells in nonlymphoid tissues in mice, thus compromising the antitumor activity of aged CD8 T cells, which we also observed in human lung adenocarcinoma. We further identified that the apoptosis regulator BFAR was highly enriched in aged CD8 T cells, in which BFAR suppressed cytokine-induced JAK2 signaling by activating JAK2 deubiquitination, thereby limiting downstream STAT1-mediated T reprogramming.

Elucidating the Structural Evolution of O3-type NaNiFeMnO: A Prototype Cathode for Na-Ion Battery.

Extending the depth-of-charge (DoC) of the layered oxide cathode presents an essential route to improve the competitiveness of the Na-ion battery versus the commercialized LiFePO-based Li-ion battery (0.8 CNY/Wh). However, the DoC-dependent boundary between detrimental/irreversible structural distortion and neutral/reversible structure interconversion cannot be clearly distinguished, which is attributed to the ambiguous recognition of correlation among the complex phase transition, local covalent environment evolution, and charge compensation.

FGL2 peptides improve the antitumor effect of HCMV-IE1mut vaccine against glioblastoma by modulating immunosuppressive cells in the tumor microenvironment.

Glioblastoma multiforme (GBM) is a highly aggressive primary brain tumor characterized by poor prognosis and lack of effective treatments. In recent years, peptide vaccines that use sequences based on tumor-specific or tumor-associated antigens to activate immune responses against tumor cells have emerged as a new therapeutic strategy. In this study, we developed a novel therapeutic polypeptide vaccine targeting the tumor-associated antigen Fibrinogen-Like Protein 2 (FGL2), whose dominant epitope peptide was tandemly linked to the C-terminus of HCMV-IE1mut via a linker.

Urinary Microalbumin predicts early neurological deterioration in acute ischemic stroke: A study based on etiological classification.

Introduction: To investigate the correlation between urinary microalbumin (U-Alb) levels and early neurological deterioration (END), as well as its predictive ability, in patients with acute ischemic stroke (AIS) under different etiological subtypes.

Materials And Methods: We consecutively enrolled AIS patients within 72 h of onset, collecting relevant clinical characteristics and baseline laboratory data including U-Alb. END was defined as an increase of ≥4 points in NIHSS score within 72 h of onset, and TOAST criteria were used for stroke etiologic typing.

A novel fluorescent probe based on coumarin derivatives-grafted cellulose for specific detection of Fe and its application.

Fe is one of the most important ions for maintaining the normal growth of plants and animals. However, imbalance and accumulation of Fe can lead to serious damage to the environmental system. Hence, it is considerably crucial to monitor the concentration of Fe.

A novel dialdehyde cellulose-based colorimetric and turn-on fluorescent probe for HS detection and its application in red wine.

Hydrogen sulfide (HS) is considered one of the most important gaseous transmitters in the metabolic system, and the abnormal concentration of HS is associated with a variety of diseases. Up to now, it is still a challenge to develop a portable assay for HS even though the research about the detection of HS is booming. Herein, a novel bifunctional dialdehyde-cellulose fluorescent probe DAC-DPD was prepared with high selectivity and sensitivity to HS with colorimetric and fluorescent "turn-on" characteristics, and the limit of detection (LOD) of DAC-DPD for HS was 0.

Molecular Regulation of Shoot Architecture in Soybean.

Soybean (Glycine max [L.] Merr.) serves as a major source of protein and oil for humans and animals.

Danggui Buxue decoction regulates the immune function and intestinal microbiota of cyclophosphamide induced immunosuppressed mice.

Ethnopharmacological Relevance: Danggui Buxue decoction (DBD) is a traditional Chinese herbal formula. According to the theory of traditional Chinese medicine, the combination of (AR) and (AS) is a classic prescription of tonifying and enriching blood. DBD has the functions of hematopoietic, immune enhancement and inflammation inhibition, usually used to treat qi and blood deficiency symptoms.

A Fe-NC electrocatalyst boosted by trace bromide ions with high performance in proton exchange membrane fuel cells.

Replacement of expensive and rare platinum with metal-nitrogen-carbon catalysts for oxygen reduction reactions in proton exchange membrane fuel cells is hindered by their inferior activity. Herein, we report a highly active iron-nitrogen-carbon catalyst by optimizing the carbon structure and coordination environments of Fe-N sites. A critical high-temperature treatment with ammonium chloride and ammonium bromide not only enhances the intrinsic activity and density of Fe-N sites, but also introduces numerous defects, trace Br ions and creates mesopores in the carbon framework.

Spatial-temporal pattern of ecosystem services and sustainable development in representative mountainous cities: A case study of Chengdu-Chongqing Urban Agglomeration.

The Sustainable Development Goals (SDGs) are essential measure for preserving the balance between human well-being and natural ecosystems. The benefit of preserving ecosystems health play a crucial role in promoting the SDGs by providing stable ecosystem services (ESs). However, the ecological health of mountainous cities is vulnerable, with relative low ecological resilience.

6-Methoxyldihydrochelerythrine Chloride Inhibiting Intra and Extracellular Drug-Resistant Bacteria.

Vancomycin-resistant enterococcus (VRE) is a major nosocomial pathogen that exhibits enhanced infectivity due to its robust virulence and biofilm-forming capabilities. In this study, 6-methoxyldihydrochelerythrine chloride (6-MDC) inhibited the growth of exponential-phase VRE and restored VRE's sensitivity to vancomycin. 6-MDC predominantly suppressed the biosynthetic pathway of pyrimidine and purine in VRE by the RNA-Seq analysis, resulting in obstructed DNA synthesis, which subsequently weakened bacterial virulence and impeded intracellular survival.

Food-derived skin-care ingredient as a promising strategy for skin aging: Current knowledge and future perspectives.

Skin aging involves complex biochemical reactions and has attracted a growing concern recently. For it, there is a great desire to replace the hazardous and easy-recurring "therapy means" with "daily care" based on some natural and healthy ingredients. According to a novel theory called "homology of cosmetic and food", the safety, efficacy and accessibility of food-derived skin-care ingredients offer an attractive option for combating skin aging, which will be an inevitable trend of dermatology in the future.

Early prediction of microvascular invasion (MVI) occurrence in hepatocellular carcinoma (HCC) by F-FDG PET/CT and laboratory data.

Background: Hepatocellular carcinoma (HCC) is one of the deadliest malignant tumors in China. Microvascular invasion (MVI) often indicates poor prognosis and metastasis in HCC patients. F-FDG PET-CT is a new imaging method commonly used to screen for tumor occurrence and evaluate tumor stage.

An in situ exploration of how Fe/N/C oxygen reduction catalysts evolve during synthesis under pyrolytic conditions.

In pursuing cheap and effective oxygen reduction catalysts, the Fe/N/C system emerges as a promising candidate. Nevertheless, the structural transformations of starting materials into Fe- and N-doped carbon catalysts remains poorly characterized under pyrolytic conditions. Here, we explore the evolution of Fe species and track the formation of Fe-N site development by employing diverse in-situ diagnostic techniques.

Effects of weight-bearing dance aerobics on lower limb muscle morphology, strength and functional fitness in older women.

Objective: To investigate the effects of 12-week weight-bearing dance aerobics (WBDA) on muscle morphology, strength and functional fitness in older women.

Methods: This controlled study recruited 37 female participants (66.31y ± 3.