BMP10 Knockdown Modulates Endothelial Cell Immunoreactivity by Inhibiting the HIF-1α Pathway in the Sepsis-Induced Myocardial Injury.

Sepsis is a life-threatening syndrome triggered by a cascade of dysregulated immune responses. Sepsis-induced myocardial injury (SIMI) substantially impacts the survival time of septic patients. However, the molecular mechanisms underlying the pathology of SIMI remain unclear.

Tunable High-Performance Electromagnetic Interference Shielding of VO Nanowires-Based Composite.

The unique metal-insulator transition of VO is very suitable for dynamic electromagnetic (EM) regulation materials due to its sharp change in electrical conductivity. Here, we have developed an off/on switchable electromagnetic interference (EMI) shielding composite by interconnecting VO nanowires (NWs) in poly(vinylidene fluoride--hexafluoropropylene) (PVDF-HFP) to form conductive networks, resulting in outstanding performance at the X and Ku bands with maximum change values of 44.8 and 59.

A Time Mode Pulse Interleaver in a Silicon-on-Insulator Platform for Optical Analog-to-Digital Converters.

We propose and demonstrate a novel on-chip optical sampling pulse interleaver based on time mode interleaving. The designed pulse interleaver was fabricated on a 220 nm silicon-on-insulator (SOI) platform, utilizing only one S-shaped delay waveguide. Interleaving is achieved by the relative time delay between different optical modes in the waveguide, eliminating the need for any active tuning.

Unprecedented Spatial Manipulation and Transformation of Dynamic Thermal Radiation Based on Vanadium Dioxide.

Reconfigurable infrared (IR) materials have widespread applications in thermal management and smart IR concealment. Although various reconfigurable IR materials can be customized by positive or negative differential VO-based resonators, their insightful mechanism remains unknown. Here, we comprehensively investigate the fundamental design rule of reconfigurable thermal radiation between positive and negative differential thermal radiation properties for the first time.

Monolithically integrated 128-channel hybrid mode/polarization/wavelength (de)multiplexer on silicon-on-insulator.

In this paper, we proposed a 128-channel hybrid mode/polarization/wavelength (de)multiplexer by monolithically integrating four 16-wavelength-channel (de)multiplexers based on bi-directional MRRs arrays and an 8-channel hybrid mode/polarization (de)multiplexer. The hybrid mode/polarization (de)multiplexer consists of a polarization beam splitter (PBS) and cascaded six asymmetric directional couplers (ADCs). The present 128-channel hybrid (de)multiplexer utilizes four modes, dual polarizations, and sixteen wavelengths to improve the data transmission capacity of optical communication systems.

Genome-wide CRISPR off-target prediction and optimization using RNA-DNA interaction fingerprints.

The powerful CRISPR genome editing system is hindered by its off-target effects, and existing computational tools achieved limited performance in genome-wide off-target prediction due to the lack of deep understanding of the CRISPR molecular mechanism. In this study, we propose to incorporate molecular dynamics (MD) simulations in the computational analysis of CRISPR system, and present CRISOT, an integrated tool suite containing four related modules, i.e.

γ-Secretase inhibitor alleviates lipopolysaccharide-induced myocardial injury through regulating JAK2/STAT3 signaling.

Background: Septic myocardial injury is one of the most life-threatening organ dysfunction. The γ-secretase-based approaches have been developed as potential strategies for diverse diseases management. Unfortunately, the role of γ-secretase inhibitor in septic myocardial injury is unclarified.

A Novel Silicon Forward-Biased PIN Mach-Zehnder Modulator with Two Operating States.

In this paper, we demonstrate a silicon forward-biased positive intrinsic negative (PIN) Mach-Zehnder modulator (MZM), which has two operating states of high efficiency and high speed. The two operating states are switched by changing the position where the electric signal is loaded. The modulator incorporates a PIN phase shifter integrated with the passive resistance and capacitance (RC) equalizer (PIN-RC), which expands the electro-optic (E-O) bandwidth by equalizing it with modulation efficiency.

Silicon nitride assisted tri-layer edge coupler on lithium niobate-on-insulator platform.

Lithium niobate-on-insulator (LNOI) is a promising integration platform for various applications, such as optical communication, microwave photonics, and nonlinear optics. To make Lithium niobate (LN) photonic integrated circuits (PICs) more practical, low-loss fiber-chip coupling is essential. In this Letter, we propose and experimentally demonstrate a silicon nitride (SiN) assisted tri-layer edge coupler on LNOI platform.

Comparative transcriptome analysis of Saposhnikovia divaricata to reveal drought and rehydration adaption strategies.

Background: Water scarcity has become one of the most prevalent environmental factors adversely affecting plant growth and development. Different species have developed multiple ways of drought resistance. Saposhnikovia divaricata is a commonly used traditional herb in East Asia.

The expression and biological effect of NR2F6 in non-small cell lung cancer.

Objective: This study aimed to explore the expression and effect of the nuclear receptor subfamily 2 group F member 6 (NR2F6) gene in non-small cell lung cancer (NSCLC) and provide an experimental basis for the targeted therapy of NSCLC.

Method: First, the expression of NR2F6 in lung cancer tissues was analyzed using the Gene Expression Omnibus and the Cancer Genome Atlas (TCGA) databases, and the expression of NR2F6 in lung cancer tissues and cells was verified by Western blotting and quantitative polymerase chain reaction. Next, the relationship between NR2F6 expression and the clinicopathological features of lung cancer was analyzed immunohistochemistry, and the relationship between NR2F6 expression and prognosis was analyzed using the Kaplan-Meier Plotter.

PALD encoding a lipid droplet-associated protein is critical for the accumulation of lipid droplets and pollen longevity in Arabidopsis.

Pollen longevity is critical for plant pollination and hybrid seed production, but few studies have focused on pollen longevity. In this study, we identified an Arabidopsis thaliana gene, Protein associated with lipid droplets (PALD), which is strongly expressed in pollen and critical for the regulation of pollen longevity. PALD was expressed specifically in mature pollen grains and the pollen tube, and its expression was upregulated under dry conditions.

VO-Based Infrared Radiation Regulator with Excellent Dynamic Thermal Management Performance.

Dynamic thermal management materials attract fast-increasing interest due to their adaptability to changing environments and greater energy savings as compared to static materials. However, the high transition temperature and the low emittance tunability of the vanadium dioxide (VO)-based infrared radiation regulators limit their practical applications. This study addresses these issues by proposing a smart infrared radiation regulator based on a Fabry-Pérot cavity structure (VO/HfO/Al), which is prepared by high-power impulse magnetron sputtering (HiPIMS) and has the potential for large-scale production.

C-band four-channel CWDM (de-)multiplexers on a thin film lithium niobate-silicon rich nitride hybrid platform.

A four-channel coarse wavelength division multiplexing (CWDM) (de)multiplexer on a thin film lithium niobate-silicon rich nitride hybrid platform has been designed, fabricated, and experimentally measured. Enabled by cascaded multimode waveguide Bragg gratings, the (de)multiplexer has a box-like spectral response, wide 1-dB bandwidth (10 nm), low excess loss (<1.08), and low channel cross talk (<-18).

On-chip four-mode (de-)multiplexer on thin film lithium niobate-silicon rich nitride hybrid platform.

A four-mode (de-)multiplexer with transverse electric field light (-) is experimentally demonstrated on a thin film lithium niobate-silicon rich nitride hybrid platform. Enabled by cascaded asymmetrical directional couplers, a (de-)multiplexer with low insertion loss (0.38 dB to 1.

40 GHz high-efficiency Michelson interferometer modulator on a silicon-rich nitride and thin-film lithium niobate hybrid platform.

We propose and demonstrate a Michelson interferometer modulator with integrated Bragg reflectors on a silicon-rich nitride-thin-film lithium niobate hybrid platform. High-reflectivity Bragg reflectors are placed at the ends of both arms, which double the electro-optic (E-O) interaction length and reduce the velocity mismatch between the microwave and optical wave. The presented Michelson interferometer modulator achieves a measured half-wave voltage length product as low as 1.

Efficient grating couplers on a thin film lithium niobate-silicon rich nitride hybrid platform.

A grating coupler on a thin film -cut lithium niobate-silicon rich nitride hybrid platform is proposed and demonstrated. An inverse taper is applied to suppress higher-order mode excitation. A coupling efficiency of -5.

Ultra-compact low-loss variable-ratio 1×2 power splitter with ultra-low phase deviation based on asymmetric ladder-shaped multimode interference coupler.

We propose a novel optical 1×2 power splitter based on an asymmetric ladder-shaped multimode interference (MMI) coupler in silicon-on-insulator (SOI) which has an ultra-compact size of 3.3 µm×2.4 µm.

Passive silicon ring-assisted Mach-Zehnder interleavers operating in the broadband spectral range.

We propose and experimentally demonstrate a passive and compact interleaver on a silicon on insulator (SOI) platform using a ring-assisted asymmetrical Mach-Zehnder interferometer configuration. The wavelength-insensitive couplers, i.e.

TE/TM-pass polarizers based on lateral leakage in a thin film lithium niobate-silicon nitride hybrid platform: publisher's note.

This publisher's note contains a correction to Opt. Lett.45, 4915 (2020)OPLEDP0146-959210.

TE/TM-pass polarizers based on lateral leakage in a thin film lithium niobate-silicon nitride hybrid platform.

TE/TM-pass polarizers based on the lithium niobate-silicon nitride hybrid platform are numerically proposed for the first time, to the best of our knowledge. By utilizing the lateral leakage of a shallowly etched rib waveguide, 1-mm-long TE/TM-pass polarizers with high extinction ratios of 28.72/24.

A Novel Method for Notable Reducing Phase Transition Temperature of VO Films for Smart Energy Efficient Windows.

Although Vanadium dioxide (VO) has a potential application value for smart energy efficient windows because of its unique phase transition characteristic, there are still many obstacles that need to be overcome. One challenge is to reduce its high transition temperature ( = 68 °C) to near room temperature without causing its phase transition performance degradation. In this paper, a novel method was employed that covered a 3 nm ultra-thin heavy Cr-doped VO layer on the pure VO films.

Ultra-compact low-loss 1 × 4 optical power splitter with splitting ratio of 1∶2∶4∶8 based on two-stage cascaded MMI couplers.

An ultra-compact low-loss 1×4 optical power splitter with a splitting ratio of 1∶2∶4∶8 is proposed and demonstrated on a 220-nm-thick silicon-on-insulator (SOI) platform at the C band. The splitter is based on two stages of a cascaded 1×3 multimode interference (MMI) coupler and a 4×4 MMI coupler. The footprint of the device is 124.

Polarization beam splitter based on a silicon nitride-silica-silicon horizontal slot waveguide.

A novel compact polarization beam splitter (PBS) based on a silicon nitride-silica-silicon horizontal slot waveguide is numerically proposed, to the best of our knowledge. In the slot waveguide, the transverse electric (TE) mode propagates through the silicon layer, while the transverse magnetic (TM) mode is confined in the slot region. By utilizing an asymmetric directional coupler (DC) and bent directional coupler (bent DC) consisting of a slot waveguide and a thin silicon waveguide, PBSs with 14.