Ultrasonographic modeling of lung and diaphragm mechanics: clinical trial of a novel non-invasive method to evaluate pre-operative pulmonary function.

Background: Pre-operative pulmonary function testing (PFT) plays a key role in predicting postoperative complications or functional impairment. However, PFT requires the subject and examiner to cooperate and the results are influenced by both technical and personal factors. In contrast, the use of ultrasound (US) for structural and functional assessments of the lungs and diaphragm is on the rise, as it requires minimal patient cooperation.

Enhanced chloramphenicol biodegradation and sustainable electricity generation via co-cultured electroactive biofilms modified with in-situ self-assembled gold nanoparticles and reduced graphene oxide.

Bioelectrochemical technology emerges as a promising approach for addressing the challenge of antibiotic residue contamination. This research innovated by incorporating in-situ self-assembled gold nanoparticles (Au-NPs) and reduced graphene oxide (rGO) into a co-cultured electroactive biofilm (EAB) of Raoultella sp. DB-1 and Shewanella oneidensis MR-1 (Au-rGO@R/S-C).

Isoflurane anesthesia decreases excitability of inhibitory neurons in the basolateral amygdala leading to anxiety‑like behavior in aged mice.

Anxiety after surgery can be a major factor leading to postoperative cognitive dysfunction, particularly in elderly patients. The role of inhibitory neurons in the basolateral amygdala (BLA) in anxiety-like behaviors in aged mice following isoflurane anesthesia remains unclear. Therefore, the present study aimed to investigate the role of inhibitory neurons in isoflurane-treated mice.

Abrupt shift in the organic matter input to sediments in Lake Liangzi, a typical macrophyte-dominated shallow lake in Eastern China, and its response to anthropogenic impacts.

Understanding the historical variations in organic matter (OM) input to lake sediments and the possible mechanisms regulating this phenomenon is important for studying carbon cycling and burial in lake systems; however, this topic remains poorly addressed for macrophyte-dominated lakes. To bridge these gaps, we analyzed bulk OM and molecular geochemical proxies in a dated sediment core from Lake Liangzi, a typical submerged macrophyte-dominated lake in East China, to infer changes in OM input to sediments over the past 169 years due to the intensification of human activities in the catchment. A relatively primitive OM input pattern was observed in ca.

3D Scene Creation and Rendering via Rough Meshes: A Lighting Transfer Avenue.

This paper studies how to flexibly integrate reconstructed 3D models into practical 3D modeling pipelines such as 3D scene creation and rendering. Due to the technical difficulty, one can only obtain rough 3D models (R3DMs) for most real objects using existing 3D reconstruction techniques. As a result, physically-based rendering (PBR) would render low-quality images or videos for scenes that are constructed by R3DMs.

Environment change recorded by lake sediment magnetism in the Songnen Plain, northeastern China.

Stratigraphic determination of the Anthropocene, the "Great Acceleration", requires more key globally synchronous stratigraphic markers which reflect the significant human impacts on Earth. Lacustrine sediment magnetic characteristics are of considerable importance in Anthropocene studies because they respond sensitively to environmental changes. There are many shallow lakes in the Songnen Plain (SNP) in northeast China, which are conducive to obtaining Anthropocene sedimentary records.

The Therapeutic Synergy of Selinexor and Venetoclax in Mantle Cell Lymphoma Through Induction of DNA Damage and Perturbation of the DNA Damage Response.

Mantle cell lymphoma (MCL) can be stratified into blastoid and classical subtypes based on morphological features, with the former subtype having a poorer prognosis. Despite recent advances in targeted approaches, including multiple bruton tyrosine kinase inhibitors which yield impressive clinical responses and improve prognoses, MCL remains an incurable disease with frequent relapses. Additional therapeutic interventions are therefore unmet medical needs for the management of patients with MCL.

Geochemical records of human-induced environmental changes in two small remote lakes of Songnen Plain, Northeast China.

The abundance and composition of aliphatic hydrocarbon biomarkers were determined in dated sediment cores from Lakes Qijiapao (QJP) and Huoshaoheipao (HSH) in the Songnen Plain, Northeast China, to investigate historical environmental changes in these lakes and identify likely controlling factors. Based on these results, the recent environmental history of the two lakes can be divided into three periods. Before 1950, low P values (avg.

A rare imaging presentation with multisystemic clinicopathological features of Langerhans cell histiocytosis: Case report and literature review.

Rationale: Langerhans cell histiocytosis (LCH) is a kind of rare disease in which dendritic cells proliferate abnormally. It often occurs in children and can involve any tissue and organ. The affected sites usually include bone, skin, pituitary gland, and lungs, while the thyroid gland and external auditory canal are rarely observed.

Synthesis and Biological Activities of Oxazolidinone Pleuromutilin Derivatives as a Potent Anti-MRSA Agent.

A series of pleuromutilin derivatives containing an oxazolidinone skeleton were synthesized and evaluated in vitro and in vivo as antibacterial agents. Most of the synthesized derivatives exhibited potent antibacterial activities against three strains of (including MRSA ATCC 33591, MRSA ATCC 43300, and MSSA ATCC 29213) and two strains of (including MRSE ATCC 51625 and MSSE ATCC 12228). Compound was the most active antibacterial agent in vitro (MIC = 0.

Sediment geochemical records of water quality deterioration in lake Jiren, a remote alpine lake on the southeastern margin of the Tibetan Plateau.

Limited human activities in catchments make remote alpine lakes valuable sites for studying the evolution of lake environments in response to climate change and atmospheric deposition; however, this issue remains rarely studied owing to the scarcity of monitoring data. In this study, water quality evolution in Lake Jiren, a remote alpine lake on the southeastern margin of the Tibetan Plateau, over the past two centuries was reconstructed through geochemical analyses of aliphatic hydrocarbons, major and trace elements, and organic matter (OM) pyrolysis products in a dated sediment core, and the associated drivers were identified by temporally comparing the geochemical results with document records. All geochemical data demonstrated that the lake water remained relatively pure until 1947, after which the n-alkane and αβ-hopane proxies indicated eutrophication and petroleum contamination.

Network pharmacology- and molecular docking-based investigation of the therapeutic potential and mechanism of daucosterol against multiple myeloma.

Background: Some studies have shown that daucosterol has potential anti-tumor activity, but its therapeutic effect on multiple myeloma (MM) has not been reported. This study aimed to evaluate the therapeutic effect daucosterol against MM and explore its possible mechanism through network pharmacology.

Methods: We collected daucosterol and approved drugs for MM, and their potential target profiles were obtained.

Aberrantly expressed long noncoding RNAs as potential prognostic biomarkers in newly diagnosed multiple myeloma: A systemic review and meta-analysis.

Background: Numerous studies have manifested long noncoding RNAs (lncRNAs) as biomarkers to determine the prognosis of multiple myeloma (MM) patients. Nevertheless, the prognostic role of lncRNAs in MM is still ambiguous. Herein, we performed a meta-analysis to evaluate the predictive value of aberrantly expressed lncRNAs in MM.

PARP-1 inhibitors enhance the chemosensitivity of leukemia cells by attenuating NF-кB pathway activity and DNA damage response induced by Idarubicin.

Idarubicin (IDA), an anthracycline antineoplastic drug, is commonly used in the treatment of acute myeloid leukemia (AML) with reasonable response rates and clinical benefits. However, some patients still relapse, or do not respond, and suffer high fatality rates. Recent studies have shown that overexpression of PARP-1 may represent an important risk factor in AML patients.

Geochemical records of Lake Erhai (South-Western China) reveal the anthropogenically-induced intensification of hypolimnetic anoxia in monomictic lakes.

In monomictic lakes, hypolimnetic anoxia is becoming severe in extent and duration over the past few decades. Understanding historical trends in hypolimnetic dissolved oxygen (DO) levels and the factors controlling them is crucial for effective protection and management of monomictic lakes everywhere, but the issue remains little studied in China. Here, our study elucidated the variation of hypolimnion DO and organic matter (OM) input in Lake Erhai (a typical monomictic lake in South-Western China) during the past 200 years, by using the geochemical profiles of elements (C, N, P, S, Mo, Ca, and Al) and aliphatic hydrocarbons in a dated sediment core.

Rational Design of Pt-Pd-Ni Trimetallic Nanocatalysts for Room-Temperature Benzaldehyde and Styrene Hydrogenation.

Nanostructures of the multimetallic catalysts offer great scope for fine tuning of heterogeneous catalysis, but clear understanding of the surface chemistry and structures is important to enhance their selectivity and efficiency. Focussing on a typical Pt-Pd-Ni trimetallic system, we comparatively examined the Ni/C, Pt/Ni/C, Pd/Ni/C and Pt-Pd/Ni/C catalysts synthesized by impregnation and galvanic replacement reaction. To clarify surface chemical/structural effect, the Pt-Pd/Ni/C catalyst was thermally treated at X=200, 400 or 600 °C in a H reducing atmosphere, respectively termed as Pt-Pd/Ni/C-X.

Adaptive Context-Aware Multi-Modal Network for Depth Completion.

Depth completion aims to recover a dense depth map from the sparse depth data and the corresponding single RGB image. The observed pixels provide the significant guidance for the recovery of the unobserved pixels' depth. However, due to the sparsity of the depth data, the standard convolution operation, exploited by most of existing methods, is not effective to model the observed contexts with depth values.

Four new phenanthrene derivatives from Bulbophyllum retusiusculum.

Three new dihydrophenanthrenes, retusiusine D (1), retusiusine E (2), retusiusine F (3), and a new phenanthrene retusiusine G (4), together with two known dihydrophenanthrenes 4,7-dihydroxy-2,3-methylenedioxy-9,10-dihydrophenanthrene (5) and epemeranthol-A (6) were isolated from the tubers of Bulbophyllum retusiusculum. Their structures were established on the basis of extensive spectroscopic analyses. Compounds 1 and 2 exhibited potent cytotoxic activities against SMMC-7721 and weak cytotoxic activities against HL-60.

Role of mechanical and oral antibiotic bowel preparation in children with Hirschsprung's disease undergoing colostomy closure and pull-through.

Background: Mechanical and oral antibiotic bowel preparation (MOABP) has been performed routinely before colorectal surgery in children, but the necessity was questioned recently. We evaluated the utility of MOABP in children with Hirschsprung's disease (HSCR) undergoing colostomy closure and pull-through.

Methods: The medical records of pediatric patients with HSCR who underwent colostomy closure and pull-through in a single center from January 2010 to January 2020 were reviewed.

Occlusion Boundary: A Formal Definition & Its Detection via Deep Exploration of Context.

Occlusion boundaries contain rich perceptual information about the underlying scene structure and provide important cues in many visual perception-related tasks such as object recognition, segmentation, motion estimation, scene understanding, and autonomous navigation. However, there is no formal definition of occlusion boundaries in the literature, and state-of-the-art occlusion boundary detection is still suboptimal. With this in mind, in this paper we propose a formal definition of occlusion boundaries for related studies.

Molecular docking studies, anti-Alzheimer's disease, antidiabetic, and anti-acute myeloid leukemia potentials of narcissoside.

In this research, we explored their capacity for Narcissoside antioxidant and anticholinergic, antidiabetic, and anti-acute myeloid leukaemia. Narcissoside's antioxidant activities were elucidated by the use of various bioanalytical assays. Narcissoside's radical scavenging activities were evaluated by DPPH and ABTS scavenging activities.

Geometry-Consistent Generative Adversarial Networks for One-Sided Unsupervised Domain Mapping.

Unsupervised domain mapping aims to learn a function G to translate domain to in the absence of paired examples. Finding the optimal without paired data is an ill-posed problem, so appropriate constraints are required to obtain reasonable solutions. While some prominent constraints such as cycle consistency and distance preservation successfully constrain the solution space, they overlook the special properties of images that simple geometric transformations do not change the image's semantic structure.

Multiresponsive Microgels with Phase-Separated Nanodomains and Self-Regulating Properties via Incorporation of Anthraquinone Moieties.

Of the multitude of stimuli-responsive microgels, it is still a challenge to achieve multiple responsivenesses to one single stimulus, which can even revert to the corresponding original state autonomously after stimulus. In this work, we reported a series of anthraquinone functionalized microgels (PNI-VAQ) with thermosensitivity and redox-actuated self-regulating color, size, and fluorescent properties, which were easily synthesized via surfactant-free emulsion copolymerization (SFEP) with -isopropylacrylamide (NIPAm) as the monomer, 2-vinylanthraquinone (VAQ) as the comonomer, and ,'-methylenebis(acrylamide) (BIS) as the cross-linker in an aqueous solution at 70 °C. The hydrophobic interactions of comonomer VAQ also led to the formation of internal phase-separated hydrophobic nanodomains in the obtained PNI-VAQ microgels.

Kaixinsan, a Well-Known Chinese Herbal Prescription, for Alzheimer's Disease and Depression: A Preclinical Systematic Review.

Alzheimer's disease (AD), the most common cause of dementia, is highly prevalent worldwide with no modifying therapy. Behavioral and psychological symptoms of dementia (BPSD) occur in most patients with AD, and depression is one of the most common AD-related BPSD. Kaixinsan (KXS) is an ancient Chinese herbal prescription widely used to treat dementia and forgetfulness.