Publications by authors named "Huan Chang"

In this Letter, we propose a novel, to the best of our knowledge, end-to-end (E2E) learning scheme leveraging a time-frequency decoupling network (TFDnet) for joint probabilistic shaping (PS) and pre-equalization in hollow-core fiber (HCF)-based wavelength division multiplexing (WDM) systems. The TFDnet emulator effectively models HCF transmission channels by decoupling signal impairments into high-frequency, linear, and nonlinear distortions. Furthermore, a TFDnet emulator-based E2E strategy for joint PS and pre-equalization is presented with the aim of compensating the signal impairment for the HCF-based WDM systems.

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The presence of a selection marker in transgenic plants has raised public concerns regarding health safety. We have developed a CRISPR/Cas9-based DNA delivery system termed transgenic selection-associated fragment elimination (T-SAFE). The T-SAFE system comprises four cassettes: the selection marker, CRISPR/Cas9, spacer-plus-protospacer adjacent motif (SP), and the cargo.

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Due to mode coupling, a high signal-to-noise ratio (SNR) is required in orbital angular momentum (OAM) modular division multiplexing (MDM) systems to improve transmission performance. In this paper, a cascade delta-sigma modulation (CDSM) scheme is proposed for OAM-MDM intensity modulation and direct detection (IM/DD) transmission. Different from the traditional DSM (TDSM) scheme, the scheme is divided into signal modulation and in-band noise modulation, in which the in-band noise modulation is used to further decrease the quantization noise generated in the signal modulation.

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Orbital angular momentum (OAM) multiplexing is emerging as a critical technique for achieving high data capacity in underwater wireless optical communications (UWOC). Nonetheless, wavefront distortions induced by underwater turbulence compromise the orthogonality of OAM modes. In this paper, we introduce a physics-driven untrained learning approach for adaptive optics that operates independently of extensive amplitude datasets.

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Background: Chronic post-thoracotomy pain (CPTP) is characterized by high incidence, long duration, and severity of pain. Medial prefrontal cortex (mPFC) is a brain region closely associated with chronic pain, and norepinephrine is involved in pain regulation. But the role of mPFC norepinephrine in CPTP and its possible mechanism is unclear.

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Purpose: This study aimed to identify a lactylation-related gene signature for predicting prognosis and guiding therapies in colon adenocarcinoma (COAD). We seek to address the challenges in COAD prognostication due to tumor heterogeneity and variable treatment responses.

Methods: The study employed integrative bioinformatics analyses on multi-omics data from public databases, including gene expression profiles, clinical data, and lactylation-related genes (LRGs).

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Lymantria xylina is the most important defoliator, damaging the effective coastal windbreak tree species Casuarina equisetifolia. However, the underlying genetic mechanisms through which C. equisetifolia responds to L.

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Article Synopsis
  • * It involves collecting data from patients at Sichuan Provincial People's Hospital between 2018 and 2021, using various ML techniques to ensure the model's accuracy, interpretability, and fairness.
  • * The research is approved ethically and aims to publish findings in a peer-reviewed journal, with the best-performing predictive model being validated externally and made available online for practical use.
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Ring core fibers (RCFs) offer unique advantages in fiber image transmission, as their weakly-coupled orbital angular momentum mode groups result in high resolution images. However, severe image distortion is still exhibited during fiber transmission when subjected to strong disturbances. Here, we present a novel approach with a differential neural network, namely the polarization speckle differential imaging (PSDI) method, to significantly enhance both the robustness and image resolution of RCF-based imaging systems.

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In this study, we present an all-optical image reconstruction technique leveraging a diffractive deep neural network (D2NN) within a ring-core fiber (RCF) architecture. Orbital angular momentum (OAM) modes are employed to facilitate imaging transmission. We experimentally validate the efficacy of our approach for complex field diffractive image reconstruction through a multimode fiber (MMF) and RCF at a 1550 nm operating wavelength.

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Intensity modulation direct detection (IM/DD) orbital angular momentum (OAM) mode division multiplexing (MDM) technology can greatly expand the capacity of a communication system, which is a promising solution for the next generation of high-speed passive optical networks (PONs). However, there are serious obstacles such as mode coupling, device nonlinear impairment, and quantization noise in an IM/DD OAM-MDM system with a low-resolution digital-to-analog converter (DAC). In this Letter, we propose a novel, to the best of our knowledge, end-to-end (E2E) learning scheme based on a double residual feature decoupling network (DRFDnet) emulator with joint probabilistic shaping (PS) and noise shaping (NS) for the OAM-MDM IM/DD transmission.

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Article Synopsis
  • - The study investigates how multimodal apparent diffusion (MAD) weighted MRI can differentiate between malignant and benign breast lesions, as well as predict Ki-67 expression levels in breast cancer patients.
  • - In a sample of 93 patients, MAD imaging yielded significant differences in parameters between lesion types, with combined parameters showing improved diagnostic performance (AUC of 0.851 for malignancy and 0.691 for Ki-67 levels).
  • - Results suggest that MAD weighted MRI is effective for diagnosing breast lesions and predicting Ki-67 expression, which can aid in treatment planning.
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  • This study characterizes MYC transcription factors in Cucurbitaceae species, identifying the number of MYC genes in four species: cucumber, melon, watermelon, and Benincasa hispida.
  • The MYC proteins exhibit a conserved sequence crucial for DNA binding, with evolutionary analysis grouping them into five distinct categories and indicating their expansion before monocot-dicot divergence.
  • Expression of cucumber MYC genes varies across organs, showing significant upregulation in response to temperature stress, with differing homologous gene expressions observed in other species, suggesting diverse functions of these genes.
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Background: Cardiac blood cysts are exceedingly rare cardiac tumours usually found on cardiac valves in infants. We report and discuss a rare unique case wherein a giant atrial septal cardiac blood cyst was found in an adult.

Case Summary: A 59-year-old Chinese lady with history of hypertension, hyperlipidemia and transient ischaemic attack presented with atypical chest pain.

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  • Endothelial cells (ECs) use glycolysis for energy, and targeting hyperglycolysis in tumor vessels has emerged as a promising therapy for cancer.
  • Research showed reduced expression of the Foxp1 protein in lung carcinoma, especially in tumor vascular ECs, highlighting its importance in regulating EC metabolism.
  • The study identified a pathway involving Foxp1, Hif1α, and Hk2 that controls glycolytic metabolism and angiogenesis, leading to potential therapeutic strategies using gene knockdown techniques to limit tumor growth.
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Objective: Analyze risk factors for cardiac surgery-associated acute kidney injury (CSA-AKI) in adults and establish a nomogram model for CSA-AKI based on plasma soluble urokinase-type plasminogen activator receptor (suPAR) and clinical characteristics.

Methods: In a study of 170 patients undergoing cardiac surgery with cardiopulmonary bypass, enzyme-linked immunosorbent assay (ELISA) measured plasma suPAR levels. Multivariable logistic regression analysis identified risk factors associated with CSA-AKI.

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Gold nanoparticles (AuNPs) were extensively employed for in-situ detection sulfadiazine (SDZ) residues, yet current synthesis methods suffer from complex procedures, reagent pollution of the environment, and low particle quality. This study presents a novel synthesis method using discarded longan seed extract as a reducing agent to synthesized high-quality AuNPs, and then can be used for in-situ SDZ detection. Response surface methodology (RSM) was employed to optimize synthesis parameters, which resulted in five optimal combinations that enhanced the flexibility of synthesis.

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Article Synopsis
  • Scientists are working on a new way to improve how data is sent through special modes of light called orbital angular momentum (OAM).
  • They created a smart computer program called FDFDnet that helps fix problems with the signals as they travel, making them clearer and stronger.
  • In tests, this new method did way better than older technologies, especially by handling lots of data faster and more accurately over long distances!
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Background: Distinguishing between prostatic cancer (PCa) and chronic prostatitis (CP) is sometimes challenging, and Gleason grading is strongly associated with prognosis in PCa. The continuous-time random-walk diffusion (CTRW) model has shown potential in distinguishing between PCa and CP as well as predicting Gleason grading.

Purpose: This study aimed to quantify the CTRW parameters (α, β & Dm) and apparent diffusion coefficient (ADC) of PCa and CP tissues; and then assess the diagnostic value of CTRW and ADC parameters in differentiating CP from PCa and low-grade PCa from high-grade PCa lesions.

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Rationale And Objectives: To develop and validate a deep learning radiomics (DLR) model based on contrast-enhanced computed tomography (CT) to identify the primary source of liver metastases.

Materials And Methods: In total, 657 liver metastatic lesions, including breast cancer (BC), lung cancer (LC), colorectal cancer (CRC), gastric cancer (GC), and pancreatic cancer (PC), from 428 patients were collected at three clinical centers from January 2018 to October 2023 series. The lesions were randomly assigned to the training and validation sets in a 7:3 ratio.

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In recent years, with the development of information networks, higher requirements for transmission capacity have been recommended. Yet, at the same time, the capacity of single-mode fiber is rapidly approaching the theoretical limit. The multidimensional multiplexing technique is an effective way to solve this problem.

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Remote sensing images change detection technology has become a popular tool for monitoring the change type, area, and distribution of land cover, including cultivated land, forest land, photovoltaic, roads, and buildings. However, traditional methods which rely on pre-annotation and on-site verification are time-consuming and challenging to meet timeliness requirements. With the emergence of artificial intelligence, this paper proposes an automatic change detection model and a crowdsourcing collaborative framework.

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The probabilistic shaping (PS) technique is a key technology for fiber optic communication systems to further approach the Shannon limit. To solve the problem that nonlinear equalizers are ineffective for probabilistic shaping optical communication systems with non-uniform distribution, a distribution alignment convolutional neural network (DACNN)-aided nonlinear equalizer is proposed. The approach calibrates the equalizer using the probabilistic shaping prior distribution, which reduces the training complexity and improves the performance of the equalizer simultaneously.

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Article Synopsis
  • The study looked into using deep learning and special MRI pictures to tell the different types of brain cancer caused by lung cancer.
  • They collected data from 246 patients with a total of 456 brain tumors at five hospitals over about six years.
  • The researchers found that their new MRI method could tell the types of tumors apart better than other methods, with good success rates for distinguishing between small-cell and non-small-cell lung cancers.
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Stochastic nonlinear impairment is the primary factor that limits the transmission performance of high-speed orbital angular momentum (OAM) mode-division multiplexing (MDM) optical fiber communication systems. This Letter presents a low-complexity adaptive-network-based fuzzy inference system (LANFIS) nonlinear equalizer for OAM-MDM intensity-modulation direct-detection (IM/DD) transmission with three OAM modes and 15 wavelength division multiplex (WDM) channels. The LANFIS equalizer could adjust the probability distribution functions (PDFs) of the distorted pulse amplitude modulation (PAM) symbols to fit the statistical characteristics of the WDM-OAM-MDM transmission channel.

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