Publications by authors named "Huamin Yin"
Article Synopsis
- Maternal COVID-19 infection has been linked to a higher rate of neurodevelopmental disorders (NDDs) in children, but the reasons for this are still unclear.
- The study found that COVID-19 during pregnancy disrupts immune interactions between mother and fetus, affecting specific brain cells like astrocytes and neurons.
- A risk score based on genes from the mothers' immune cells can predict NDD risk in children, and the research also identified 10 potential drugs that might help address these issues.
Aims: Maternal immune activation (MIA) via infection during pregnancy is known to be an environmental risk factor for neurodevelopmental disorders and the development of autism spectrum disorders (ASD) in the offspring, but it still remains elusive that the molecular relevance between infection-induced abnormal neurodevelopmental events and an increased risk for ASD development.
Main Methods: Fully considering the extremely high genetic heterogeneity of ASD and the universality of risk-gene with minimal effect-sizes, the gene and pathway-based association analysis was performed with the transcriptomic and DNA methylation landscapes of temporal human embryonic brain development and ASD, and the time-course transcriptional profiling of MIA. We conducted the transcriptional profiling of mouse abnormal neurodevelopment two days following induced MIA via LPS injection at E10.
Maternal immune activation (MIA) during pregnancy is known to be an environmental risk factor for neurodevelopment and autism spectrum disorder (ASD). However, it is unclear at which fetal brain developmental windows and regions MIA induces ASD-related neurodevelopmental transcriptional abnormalities. The non-chasm differentially expressed genes (DEGs) involved in MIA inducing ASD during fetal brain developmental windows were identified by performing the differential expression analysis and comparing the common DEGs among MIA at four different gestational development windows, ASD with multiple brain regions from human patients and mouse models, and human and mouse embryonic brain developmental trajectory.
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- Maternal insults during pregnancy are linked to a higher risk of autism spectrum disorders (ASD) in children, but the specific brain changes caused by this connection are not yet fully understood.
- Researchers analyzed gene expression data from mothers of children diagnosed with ASD and compared it to typical development, focusing on brain tissue samples from ASD patients.
- The study revealed that certain genes expressed in the frontal and temporal cortices are associated with COVID-19, indicating that this virus may act as an environmental risk factor for developing ASD.
Breast cancer (BC) is one of the most common malignancies in female, and has a high mortality rate. The mechanisms of tumorigenesis and reprogramming of somatic cells have a certain degree of similarity. Here, we focus on the relationship between gene expression, signaling pathways and functions in BC compared to induced pluripotent stem cells (iPSCs).
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