Publications by authors named "Hualing Ruan"
Associations of Clinical Risk Factors and Novel Biomarkers With Age at Onset of Type 2 Diabetes.
J Clin Endocrinol Metab
December 2023
Context: Younger onset of type 2 diabetes (T2D) was associated with higher risks of vascular complications and mortality.
Objective: To prospectively assess risk profiles for incident T2D stratified by age at onset.
Methods: A total of 471 269 participants free of T2D at baseline were included from the UK Biobank.
Article Synopsis
- The study aimed to examine the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and mortality rates in individuals diagnosed with metabolic dysfunction-associated fatty liver disease (MAFLD) or nonalcoholic fatty liver disease (NAFLD).
- It analyzed data from 4,651 individuals using ultrasonography for FAT and linked mortality data from the National Death Index, finding significant death rates during follow-ups averaging around 26 years.
- Results indicated that higher serum 25(OH)D levels (above 75.0 nmol/L) were associated with lower mortality rates, with a significant nonlinear relationship identified especially in younger adults with MAFLD, suggesting a critical threshold around
Background: Long non-coding RNAs (lncRNAs) have been reported to play vital roles in diabetic nephropathy (DN). The aim of this study was to explore the function of mechanism of lncRNA KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) in DN.
Methods: DN cell models were established using high glucose (HG) treatment in human glomerular mesangial cells (HGMC) and human renal glomerular endothelial cells (HRGEC).
Diabetic nephropathy (DN), a frequent diabetes complication, has complex pathogenesis. Circular RNAs (circRNAs) circ_0000712 has been reported to be upregulated in kidney tissues and high glucose (HG)-inducted Mesangial cells (MCs). This study is designed to explore the role and mechanism of circ_0000712 in the HG-inducted MCs injury in DN.
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