Monoterpene-chalcone conjugates and diarylheptanoids isolated from the seeds of Alpinia katsumadai Hayata with cytotoxic activity.

Five undescribed monoterpene-chalcone conjugates (1-5), one undescribed hypothetical precursor of diarylheptanoid (6), two undescribed diarylheptanoids (7-8), and fourteen known compounds (9-22) were isolated from the seeds of Alpinia katsumadai. Their structures were elucidated through the interpretation of HRESIMS, NMR, ECD, and X-ray diffraction data. MTT assays on human cancer cell lines (HepG2, A549, SGC7901, and SW480) revealed that compounds 3-8, 11, and 13 exhibited broad-spectrum antiproliferative activities with IC values ranging from 3.

Kavalactones isolated from (Pers.) Burtt. et Smith with protective effects against human umbilical vein endothelial cell damage induced by high glucose.

A new kavalactone, 4'-hydroxyl dihydro-5, 6-dehydrokavain () was isolated from the petroleum ether partition of leaves of (Pers.) Burtt. et Smith, together with four known kavalactone dimers, -1,-3--(4-methoxy-2-oxopyran-6-yl)--2,-4-diphenyl cyclobutene (), aniba dimer A (), aniba dimer C (), 6,6'-(3,4-diphenylcyclobutane-1,2-diyl)(4-methoxy-2-pyran-2-one ().