Expression and Clinical Significance of Ki67 and SOX2 in Colorectal Cancer.

The purpose of the paper is to explore the expression levels and clinical significance of Ki67 and sex-determining region Y-box 2 (SOX2) in colorectal cancer. From January 2013 to December 2016, 176 patients with colorectal cancer who were pathologically diagnosed after surgery in the Department of General Surgery in Xiamen Chinese Medical Hospital are included in this study. The pathological parameters, including gender, age, pathological stage, depth of tumor invasion, lymph node metastasis, and distant metastasis, are recorded.

Lipidated Methotrexate Microbubbles: A Promising Rheumatoid Arthritis Theranostic Medicine Manipulated via Ultrasonic Irradiation.

designed lipidated methotrexate was synthesized and self-assembled into microbubbles for targeted rheumatoid arthritis theranostic treatment. Controlled lipidatedmethotrexate delivery was achieved by ultrasound-targetedmicrobubble destruction technique. Methotrexate was dissociated inflammatory microenvironment of synovial cavity, owing to representive low pH and enriched leucocyte esterase.

Correction: NLRP6 targeting suppresses gastric tumorigenesis via P14-Mdm2-P53-dependent cellular senescence.

[This corrects the article DOI: 10.18632/oncotarget.22876.

Comparing a Right- Versus Left-Side Approach in Laparoscopy-Assisted D2 Radical Gastrectomies in Overweight Patients with Gastric Cancer: A Retrospective Case-Controlled Study.

Background: The safety and efficacy of the surgical path used in laparoscopy-assisted radical gastrectomies (LARGs) is still unknown in obese patients. This study aimed to compare the value of a right-side (R-LARG) versus a left-side (L-LARG) approach in LARGs in overweight patients (defined as a body mass index (BMI) ≥ 25 kg/m2).

Methods: 213 patients with gastric cancer were divided into 2 groups: an overweight group and a normal-weight group (BMI < 25 kg/m2).

LRP6 targeting suppresses gastric tumorigenesis via P14-Mdm2-P53-dependent cellular senescence.

NLRP6, a member of the Nod-like receptor family, protects against chemically induced intestinal injury and colitis-associated colon cancer. However, the cellular mechanisms involved in this NLRP6-mediated protection remain unclear. Here, we show that NLRP6 was down-regulated in approximately 75% of primary gastric cancer cases and exhibited significant associations with advanced clinical-stage lymph node metastasis and poor overall survival.

Overexpression of COUP‑TFII suppresses proliferation and metastasis of human gastric cancer cells.

The abnormal expression of the chicken ovalbumin upstream promoter transcription factor 2 (COUP‑TFII) is associated with numerous forms of cancer, including gastric, prostate, colon and lung cancer. However, previous studies investigating the association between COUP‑TFII expression and the occurrence, recurrence, invasion and metastasis of gastric cancer are limited in number. In the present study, it was revealed that the expression of COUP‑TFII is significantly reduced in gastric carcinoma tissues compared with normal gastric mucosa cells (GES‑1).

miR-411-5p inhibits proliferation and metastasis of breast cancer cell via targeting GRB2.

miR-411-5p (previously called miR-411) is severely involved in human diseases, however, the relationship between miR-411-5p and breast cancer has not been investigated thoroughly. Here, we found that the expression of miR-411-5p was downregulated in breast cancer tissues compared with their matched adjacent non-neoplastic tissues. In addition, the expression of miR-411-5p was also lower in breast cancer cell lines in contrast with MCF-10A.