Design, Synthesis, Biological Evaluation and Molecular Docking of Novel F-18-Labeled Focal Adhesion Kinase Inhibitors as Potential Tumor Radiotracers.

Tumor diagnosis, especially at the early stages, holds immense significance. Focal adhesion kinase (FAK) is often highly expressed across various types of tumors, making it a promising target for both therapy and diagnosis. In this study, seven novel inhibitors were designed and synthesized.

BIDL: a brain-inspired deep learning framework for spatiotemporal processing.

Brain-inspired deep spiking neural network (DSNN) which emulates the function of the biological brain provides an effective approach for event-stream spatiotemporal perception (STP), especially for dynamic vision sensor (DVS) signals. However, there is a lack of generalized learning frameworks that can handle various spatiotemporal modalities beyond event-stream, such as video clips and 3D imaging data. To provide a unified design flow for generalized spatiotemporal processing (STP) and to investigate the capability of lightweight STP processing via brain-inspired neural dynamics, this study introduces a training platform called brain-inspired deep learning (BIDL).

Preparation and Preliminary Evaluation of a Promising Tc-Labeled Isonitrile-Containing 6-Thia-Fatty Acid Derivative for Myocardial Metabolism Imaging.

For over 40 years, none of the previous Tc-labeled fatty acids for myocardial imaging has potential clinical use. is the first Tc-labeled fatty acid to exhibit good myocardial uptake (2.06 ± 0.

Polarized light compass decoding.

The brains of some insects can encode and decode polarization information and obtain heading angle information. Referring to the encoding ability of insects, exponential function encoding is designed to improve the stability of the polarized light compass artificial neural network. However, in the decoding process, only neurons with the largest activation degree are used for decoding (maximum value decoding), so the heading information contained in other neurons is not used.

Polarized light sun position determination artificial neural network.

Our previous work has constructed a polarized light orientation determination (PLOD) artificial neural network. Although a PLOD network can determine the solar azimuth angle, it cannot determine the solar elevation angle. Therefore, this paper proposes an artificial neural network for polarized light solar position determination (PLSPD), which has two branches: the solar azimuth angle determination branch and the solar elevation angle determination branch.

Polarized skylight compass based on a soft-margin support vector machine working in cloudy conditions.

The skylight polarization pattern, which is a result of the scattering of unpolarized sunlight by particles in the atmosphere, can be used by many insects for navigation. Inspired by insects, several polarization navigation sensors have been designed and combined with various heading determination methods in recent years. However, up until now, few of these studies have fully considered the influences of different meteorological conditions, which play key roles in navigation accuracy, especially in cloudy weather.

Limitation of Rayleigh sky model for bioinspired polarized skylight navigation in three-dimensional attitude determination.

Insects such as desert ants and drosophilae can sense polarized skylight for navigation. Inspired by insects, many researchers have begun to study how to use skylight polarization patterns for attitude determination. The Rayleigh sky model has become the most widely used skylight polarization model for bioinspired polarized skylight navigation due to its simplicity and practicality.

Exploration of (3-benzyl-5-hydroxyphenyl)carbamates as new antibacterial agents against Gram-positive bacteria.

A series of (3-benzyl-5-hydroxyphenyl)carbamates were evaluated as new antibacterial agents. Several compounds showed potent inhibitory activity against sensitive and drug-resistant Gram-positive bacteria. The compounds are ineffective against all tested Gram-negative bacteria.

Discovery of (3-Benzyl-5-hydroxyphenyl)carbamates as New Antitubercular Agents with Potent In Vitro and In Vivo Efficacy.

A series of 3-amino-5-benzylphenol derivatives were designed and synthesized. Among them, (3-benzyl-5-hydroxyphenyl)carbamates were found to exert good inhibitory activity against H37Ra, H37Rv and clinically isolated multidrug-resistant strains (MIC = 0.625-6.

Discovery of meta-Amido Bromophenols as New Antitubercular Agents.

A series of meta-amido bromophenol derivatives were designed and synthesized. The compounds were found to potently inhibit the growth of Mycobacterium tuberculosis H37Ra. They also exhibited moderate inhibitory activity against Mycobacterium tuberculosis H37Rv and multidrug-resistant strains.

Facile synthesis of substituted diaryl sulfones via a [3 + 3] benzannulation strategy.

A base-mediated [3 + 3] benzannulation strategy for the conversion of 1,3-bis(sulfonyl)propenes and β,γ-unsaturated α-ketoesters to diaryl sulfones has been developed. This method provides facile, metal-free and efficient access to highly substituted diaryl sulfones in good to excellent yields. In addition, the sulfonyl group could be easily removed or converted to other functional groups via an organostannane intermediate.