Publications by authors named "Huajin Ou"
Mechanical ventilation (MV) remains a cornerstone of critical care; however, its prolonged application can exacerbate lung injury, leading to ventilator-induced lung injury (VILI). Although previous studies have implicated ferroptosis in the pathogenesis of VILI, the underlying mechanisms remain unclear. This study investigated the roles of ferritinophagy in ferroptosis subsequent to VILI.
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- Ventilator-induced lung injury (VILI) is a serious complication of mechanical ventilation, and capsaicin (CAP) has shown potential to reduce inflammation and oxidative stress linked to cellular damage.
- Research demonstrated that CAP protects against ferroptosis, a type of cell death, in VILI by improving mitochondrial function through SIRT3 signaling.
- The findings suggest that capsaicin could be a promising new treatment strategy for preventing lung injury related to mechanical ventilation by maintaining mitochondrial health and reducing oxidative damage.