Bilateral synchronous multiple lung cancer: an emerging problem.

Aim: Multiple primary lung cancers are becoming increasingly recognised and pose diagnostic and staging uncertainties with challenging management options and prognostication.

Case Report: We describe a case of synchronous multiple primary lung cancer occurring bilaterally, and the steps in reaching the diagnosis, initial surgical management, the intensive follow-up this underwent, and how its subsequent recurrence led to treatment with radiation therapy in light of the patient's declining fitness.

Discussion: This case highlighted that cytological recurrence could occur prior to radiological recurrence, especially for endobronchial tumors, and intensive follow-up both radiologically and endoscopically with multidisciplinary input is crucial in the management of these challenging cases where evidence-based guidelines are limited.

Real-world experience of nintedanib for progressive fibrosing interstitial lung disease in the UK.

Background: Nintedanib slows progression of lung function decline in patients with progressive fibrosing (PF) interstitial lung disease (ILD) and was recommended for this indication within the United Kingdom (UK) National Health Service in Scotland in June 2021 and in England, Wales and Northern Ireland in November 2021. To date, there has been no national evaluation of the use of nintedanib for PF-ILD in a real-world setting.

Methods: 26 UK centres were invited to take part in a national service evaluation between 17 November 2021 and 30 September 2022.

Exposure to metals and the disruption of sex hormones in 6-19 years old children: An exploration of mixture effects.

Background: Individual metals have been linked to sex hormones disruption, but the associations of metals mixture are rarely examined among children.

Methods: A total of 1060 participants of 6-19-year-old who participated in the National Health and Nutrition Examination Survey (2013-2016) were included. Eighteen metals were quantified in the whole blood and urine.

Seamount effect on phytoplankton biomass and community above a deep seamount in the tropical western Pacific.

It is generally believed that the enhancement of phytoplankton appears only in shallow and intermediate depth seamounts, while the phenomenon has also been observed in some deep seamounts by satellites recently. To figure out what effect do deep seamounts have on phytoplankton and the relevant mechanisms, the phytoplankton biomass and community on the Kocebu Seamount (depth: 1198 m) were studied. The results showed that the average Chl a concentration of the seamount was 0.

LncRNA HOTAIR modulates chondrocyte apoptosis and inflammation in osteoarthritis via regulating miR-1277-5p/SGTB axis.

Osteoarthritis (OA) is a common degenerative joint disease in the elderly. This study aimed to investigate the role and mechanism of lncRNA HOX transcript antisense RNA (HOTAIR) in lipopolysaccharide (LPS)-treated chondrocytes in OA. CHON-001 chondrocytes treated with LPS were used as a cell model of OA.

Abdominal cavity unidirectional shunt for refractory pericardial effusion 7 months after cardiac valve replacement: A case report.

Refractory pericardial effusion after repeated pericardial drainage and drug therapy for nearly half a year after cardiac valve replacement is rare. We present the case of a 36-year-old female patient who underwent an abdominal cavity unidirectional shunt for refractory massive pericardial effusion through a subxiphoid mini-incision, 7 months after cardiac valve replacement. The head end of a prefabricated bovine pericardial short tube with double leaflets on the tail was sutured to the small incised hole of the diaphragm, whereas the body and the tail of the short tube were dissociated in the left anterior hepatic space.

The seamount effect on phytoplankton in the tropical western Pacific.

The tropical western Pacific, one of the most oligotrophic seas on Earth, has a large number of seamounts. In this sea, we hypothesize that although the presence of shallow seamounts can enhance phytoplankton biomass, they do not alter the phytoplankton community composition. The concentration and distribution of size-fractionated chlorophyll a (Chl a) on the C4 Seamount were measured, and the phytoplankton community was analyzed based on photosynthetic pigments.

The Performances of Hyperspectral Sensors for Proximal Sensing of Nitrogen Levels in Wheat.

The accurate and high throughput quantification of nitrogen (N) content in wheat using non-destructive methods is an important step towards identifying wheat lines with high nitrogen use efficiency and informing agronomic management practices. Among various plant phenotyping methods, hyperspectral sensing has shown promise in providing accurate measurements in a fast and non-destructive manner. Past applications have utilised non-imaging instruments, such as spectrometers, while more recent approaches have expanded to hyperspectral cameras operating in different wavelength ranges and at various spectral resolutions.

Alteration of N-methyladenosine epitranscriptome profile in unilateral ureteral obstructive nephropathy.

To reveal the alterations of N-methyladenosine (mA) epitranscriptome profile in kidney after unilateral ureteral obstruction in mice. Total renal mA and expressions of methyltransferases and demethylases were detected by colorimetric quantification method, real-time PCR and western blot, respectively. Methylated RNA immunoprecipitation sequencing was performed to map epitranscriptome-wide mA profile.

A benchmark dataset for ensemble framework by using nature inspired algorithms for the early-stage forest fire rescue.

This paper introduces a benchmark dataset to the research article entitled "Ensemble framework by using nature inspired algorithms for the early-stage forest fire rescue - a case study of dynamic optimization problems", by Zhang et al. [7]. Rescue ensemble that consists of rescue simulator and rescue algorithm is characterized by supporting the dynamic simulation of forest fire rescue.

Experimental study on the compressive strength, damping and interfacial transition zone properties of modified recycled aggregate concrete.

At present, many modification methods have been proposed to improve the performance of recycled aggregate concrete (RAC). In this study, tests on the compressive strength and damping properties of modified RAC with the addition of different proportions of recycled coarse aggregate (RCA) (0, 50, 100%), rubber powder (10, 15, 20%), steel fibre (5, 7.5, 10%) and fly ash (15, 20, 5%) are carried out.

The Development of Hyperspectral Distribution Maps to Predict the Content and Distribution of Nitrogen and Water in Wheat ().

Quantifying plant water content and nitrogen levels and determining water and nitrogen phenotypes is important for crop management and achieving optimal yield and quality. Hyperspectral methods have the potential to advance high throughput phenotyping efforts by providing a rapid, accurate, and nondestructive alternative for estimating biochemical and physiological plant traits. Our study (i) acquired hyperspectral images of wheat plants using a high throughput phenotyping system, (ii) developed regression models capable of predicting water and nitrogen levels of wheat plants, and (iii) applied the regression coefficients from the best-performing models to hyperspectral images in order to develop prediction maps to visualize nitrogen and water distribution within plants.

Transformation of a high-dimensional color space for material classification.

Images in red-green-blue (RGB) color space need to be transformed to other color spaces for image processing or analysis. For example, the well-known hue-saturation-intensity (HSI) color space, which separates hue from saturation and intensity and is similar to the color perception of humans, can aid many computer vision applications. For high-dimensional images, such as multispectral or hyperspectral images, transformation images to a color space that can separate hue from saturation and intensity would be useful; however, the related works are limited.

Abnormally high phytoplankton biomass near the lagoon mouth in the Huangyan Atoll, South China Sea.

Nutrient concentration and phytoplankton biomass were investigated in Huangyan Atoll in May 2015. The concentrations of nutrients were very low, and dissolved inorganic nitrogen was composed mainly of ammonia. Nitrogen likely was the primary limiting factor for phytoplankton growth.

N-[(E)-4-(Methyl-sulfon-yl)benzyl-idene]-3-nitro-aniline.

In the title compound, C(14)H(12)N(2)O(4)S, the dihedral angle between the two aromatic rings is 35.65 (12)°. The crystal packing is stabilized by weak C-H⋯O hydrogen bonds and aromatic π-π ring stacking inter-actions [minimum ring centroid separation = 3.