NF2 can mediate the expression of CAMK2A in a tissue specific manner.

Meningioma is the most prevalent primary intracranial tumor, with approximately half of patients harboring NF2 alteration. The rationale behind the presence of NF2 alteration in meningiomas and its absence in non-nerve system tumors remains elusive. Therefore, meningiomas and several non-nerve system tumor types were analyzed using KEGG analysis and CRISPR/Cas 9 technology to determine the role of NF2 in regulating tissue specificity.

Nature nurtures authenticity: Mechanisms and consequences.

Contact with nature may benefit, not only the bodily organism, but also the psychological self. We proposed that, assuming humans' innate affinity for nature (the biophilia hypothesis), nature would be conducive to a sense of environment-self fit, which would be experienced as authenticity (being aligned with one's true self). We formulated several hypotheses: (a) nature fosters authenticity, and it does so through at least four plausible mechanisms: self-esteem, basic needs satisfaction (autonomy, competence, relatedness), mindfulness, and positive affect; (b) self-esteem is the strongest mechanism overall, and autonomy is the strongest mechanism of the three basic needs; (c) self-esteem and authenticity mediate sequentially the positive impact of nature on current psychological well-being (higher life satisfaction and meaning in life); and (d) authenticity mediates the positive influence of nature on longer term psychological well-being (higher life satisfaction and meaning in life, lower depression, anxiety, and stress).

Impaired AIF-CHCHD4 interaction and mitochondrial calcium overload contribute to auditory neuropathy spectrum disorder in patient-iPSC-derived neurons with AIFM1 variant.

Auditory neuropathy spectrum disorder (ANSD) is a hearing impairment caused by dysfunction of inner hair cells, ribbon synapses, spiral ganglion neurons and/or the auditory nerve itself. Approximately 1/7000 newborns have abnormal auditory nerve function, accounting for 10%-14% of cases of permanent hearing loss in children. Although we previously identified the AIFM1 c.

1-Deoxynojirimycin promotes cardiac function and rescues mitochondrial cristae in mitochondrial hypertrophic cardiomyopathy.

Hypertrophic cardiomyopathy (HCM) is the most prominent cause of sudden cardiac death in young people. Due to heterogeneity in clinical manifestations, conventional HCM drugs have limitations for mitochondrial hypertrophic cardiomyopathy. Discovering more effective compounds would be of substantial benefit for further elucidating the pathogenic mechanisms of HCM and treating patients with this condition.

Distress prospectively predicts higher nostalgia, and nostalgia prospectively predicts lower distress.

Objective: We were concerned with the relation between distress and nostalgia. At the state level, extensive research has established that momentary nostalgia is evoked by (experimentally manipulated) distress. However, at the trait level, the directionality of this relation is unclear.

Trajectory of Nostalgia in Emerging Adulthood.

We examined the change and stability of nostalgia in emerging adulthood. We followed 327 students through their 4 university years with six assessments. Nostalgia demonstrated moderate rank stability ( = .

KLF14 regulates the growth of hepatocellular carcinoma cells via its modulation of iron homeostasis through the repression of iron-responsive element-binding protein 2.

Background: Hepatocellular carcinoma (HCC) is a multifactor-driven malignant tumor with rapid progression, which causes the difficulty to substantially improve the prognosis of HCC. Limited understanding of the mechanisms in HCC impedes the development of efficacious therapies. Despite Krüpple-Like factors (KLFs) were reported to be participated in HCC pathogenesis, the function of KLF14 in HCC remains largely unexplored.

Nostalgia in the brain.

Nostalgia, a complex emotion that arises from one's yearnful memories, involves multiple psychological processes. Cognitive neuroscience research has shed light on the neural mechanism of nostalgia as well as its adaptive functions. Nostalgia involves brain regions implicated in self-reflection, autobiographical memory, emotion regulation and reward processing.

The analgesic effect of nostalgia elicited by idiographic and nomothetic approaches on thermal stimulus.

Nostalgia is shown to relieve an individual's perception of pain evoked by cold water, pressure, and thermal stimuli. However, there is no direct evidence to show the analgesic effects of different nostalgia-inducing methods on various stimulus intensities. We conducted two studies to examine the analgesic effect, at different pain intensities, after inducing nostalgia either idiographically or nomothetically.

Discerning cultural shifts in China? Commentary on Hamamura et al. (2021).

By examining the changes in the conceptual associations between individualism-collectivism and 10 other concepts based on the Google Ngram Chinese Corpus from the 1950s to the 1990s, Hamamura et al. (2021) inferred (a) no rise in individualism; (b) continuing collectivism; and (c) no effect of modernization on individualism in contemporary China. We question the validity of these conclusions given the following issues in their research: (a) misinterpretation of statistical results; (b) improper calculation of cultural associations; and (c) inappropriate generalization of specific findings.

Patterns of brain activity associated with nostalgia: a social-cognitive neuroscience perspective.

Nostalgia arises from tender and yearnful reflection on meaningful life events or important persons from one's past. In the last two decades, the literature has documented a variety of ways in which nostalgia benefits psychological well-being. Only a handful of studies, however, have addressed the neural basis of the emotion.

Thalamocortical Mechanisms for Nostalgia-Induced Analgesia.

As a predominately positive emotion, nostalgia serves various adaptive functions, including a recently revealed analgesic effect. The current fMRI study aimed to explore the neural mechanisms underlying the nostalgia-induced analgesic effect on noxious thermal stimuli of different intensities. Human participants' (males and females) behavior results showed that the nostalgia paradigm significantly reduced participants' perception of pain, particularly at low pain intensities.

Novel Evidence for the Increasing Prevalence of Unique Names in China: A Reply to Ogihara.

In this study, we aimed to address three comments proposed by Ogihara on a recent study where we found that unique names in China have become increasingly popular from 1950 to 2009. Using a large representative sample of Chinese names ( = 2.1 million), we replicated the increase in uniqueness of Chinese names from 1920 to 2005, especially since the 1970s, with multiple uniqueness indices based on name-character frequency and name-length deviation.

Is implicit social cognition developmentally stable? A longitudinal study.

To examine whether implicit social cognition is developmentally stable or variable, this study investigated three primary types of implicit social cognition (self-esteem, the gender-science stereotype, and racial attitude) across 2 years in a sample of Chinese adolescents and emerging adults (N = 608; 56% female; 15- to 27-year-olds). Rank-order stability analyses indicated that implicit self-esteem and implicit racial attitude manifested low stability (r = .16, .

Best research practices for using the Implicit Association Test.

Interest in unintended discrimination that can result from implicit attitudes and stereotypes (implicit biases) has stimulated many research investigations. Much of this research has used the Implicit Association Test (IAT) to measure association strengths that are presumed to underlie implicit biases. It had been more than a decade since the last published treatment of recommended best practices for research using IAT measures.

Nostalgia enhances detection of death threat: neural and behavioral evidence.

An experiment examined the potency of nostalgia-a sentimental longing for one's past-to facilitate detection of death-related stimuli, using functional magnetic resonance imaging (fMRI) and behavioral techniques (i.e., judgmental accuracy, reaction times).

Dopaminergic and neurotrophic genetic polymorphisms modulate the implicit gender-science stereotype.

Genetic approaches to both the gender-science stereotype and implicit social cognition have received increasing attention in recent years. We explored whether single nucleotide polymorphisms (SNPs) in dopaminergic and neurotrophic systems (i.e.

Meaning making helps cope with COVID-19: A longitudinal study.

Meaning making is a useful coping strategy in negative situations. We investigated whether making meaning in negative experiences (MINE) would help people cope with COVID-19. We conducted a three-wave longitudinal study ( = 2364) three months before, during, and after the COVID-19 outbreak in China.

The self-esteem implicit association test is valid: Evidence from brain activity.

A distinct challenge of implicit self-esteem research is the dubious validity of measures for implicit self-esteem. We conducted two event-related potential (ERP) studies to examine whether implicit self-esteem measured by the Implicit Association Test (IAT) actually reflects the automatic self-evaluation. We adopted the regular IAT and the Go/No-go Association Task (GNAT), respectively, to measure implicit self-esteem in two studies.

Oxytocin intensifies the mortality salience effect: Novel evidence for the social salience model of oxytocin.

Oxytocin plays an important role in human responses to threat processing. Few studies have directly examined the effects of oxytocin on our response to death-related stimuli. In the current study, 63 participants intranasally received either 32 IU of oxytocin or a placebo and thereafter completed a visual dot-probe task consisting of death-related and non-death related images.

Levels of interpersonal trust across different types of environment: The micro-macro interplay between relational distance and human ecology.

Social and behavioral scientists have long investigated the relationship between interpersonal trust and features of the environment. However, it remains unclear how the microenvironment of relational distance (i.e.

Viewing nature scenes reduces the pain of social ostracism.

In a series of four studies (s = 245, 135, 155, 222), we explored the effects of viewing nature scenes on promoting recovery from ostracism. We first manipulated experiences of ostracism, then randomly assigned participants to view photos of either nature, urban scenes, or neutral objects. Across all four studies, participants who viewed nature photos reported significantly lower levels of state social pain, along with significantly higher levels of affect balance and self-esteem.