Persistent but weak magnetic field at the Moon's midstage revealed by Chang'e-5 basalt.

The evolution of the lunar magnetic field can reveal the Moon's interior structure, thermal history, and surface environment. The mid-to-late-stage evolution of the lunar magnetic field is poorly constrained, and thus, the existence of a long-lived lunar dynamo remains controversial. The Chang'e-5 mission returned the heretofore youngest mare basalts from Oceanus Procellarum uniquely positioned at midlatitude.

A reinforced lunar dynamo recorded by Chang'e-6 farside basalt.

The evolution of the lunar dynamo is essential for deciphering the deep interior structure, thermal history, and surface environment of the Moon. Previous palaeomagnetic investigations on samples returned from the nearside of the Moon have established the general variation of the lunar magnetic field. However, limited spatial and temporal palaeomagnetic constraints leave the evolution of the lunar dynamo ambiguous.

Higher water content observed in smaller size fraction of Chang'e-5 lunar regolith samples.

Water has been detected in lunar regolith, with multiple sources identified through the analysis of individual grains. However, the primary origin of water in the bulk lunar regolith remains uncertain. This study presents spectroscopic analyses of water content in sealed Chang'e-5 samples.

Return to the Moon: New perspectives on lunar exploration.

Lunar exploration is deemed crucial for uncovering the origins of the Earth-Moon system and is the first step for advancing humanity's exploration of deep space. Over the past decade, the Chinese Lunar Exploration Program (CLEP), also known as the Chang'e (CE) Project, has achieved remarkable milestones. It has successfully developed and demonstrated the engineering capability required to reach and return from the lunar surface.

Predicting residual friction angle of lunar regolith based on Chang'e-5 lunar samples.

With the rapid development of human lunar exploration projects, the lunar base establishment and resource utilization are on the way, and hence it is urgent and significant to reasonably predict engineering properties of the lunar regolith, which remains to be unclear due to limited lunar samples currently accessible for geotechnical tests. In this contribution, we aim to address this outstanding challenge from the perspective of granular material mechanics. To this end, the 3D multi-aspect geometrical characteristics and mechanical properties of Chang'e-5 lunar samples are for the first time evaluated with a series of non-destructive microscopic tests.

Plio-Pleistocene deep-sea ventilation in the eastern Pacific and potential linkages with Northern Hemisphere glaciation.

Antarctic bottom water (AABW) production is a key factor governing global ocean circulation, and the present disintegration of the Antarctic Ice Sheet slows it. However, its long-term variability has not been well documented. On the basis of high-resolution chemical scanning of a well-dated marine ferromanganese nodule from the eastern Pacific, we derive a record of abyssal ventilation spanning the past 4.

Expanded geographic distribution and dietary strategies of the earliest Oldowan hominins and .

The oldest Oldowan tool sites, from around 2.6 million years ago, have previously been confined to Ethiopia's Afar Triangle. We describe sites at Nyayanga, Kenya, dated to 3.

In situ detection of water on the Moon by the Chang'E-5 lander.

We report analysis results of the reflectance spectra (0.48 to 3.2 μm) acquired by the Chang’E-5 lander, which provides vital context of the returned samples from the Northern Oceanus Procellarum of the Moon.

A dry lunar mantle reservoir for young mare basalts of Chang'e-5.

The distribution of water in the Moon's interior carries implications for the origin of the Moon, the crystallization of the lunar magma ocean and the duration of lunar volcanism. The Chang'e-5 mission returned some of the youngest mare basalt samples reported so far, dated at 2.0 billion years ago (Ga), from the northwestern Procellarum KREEP Terrane, providing a probe into the spatiotemporal evolution of lunar water.

Rapid drift of the Tethyan Himalaya terrane before two-stage India-Asia collision.

The India-Asia collision is an outstanding smoking gun in the study of continental collision dynamics. How and when the continental collision occurred remains a long-standing controversy. Here we present two new paleomagnetic data sets from rocks deposited on the distal part of the Indian passive margin, which indicate that the Tethyan Himalaya terrane was situated at a paleolatitude of ∼19.

The appearance and duration of the Jehol Biota: Constraint from SIMS U-Pb zircon dating for the Huajiying Formation in northern China.

The Lower Cretaceous Huajiying Formation of the Sichakou Basin in northern Hebei Province, northern China contains key vertebrate taxa of the early Jehol Biota, e.g., , , , and This formation arguably documents the second-oldest bird-bearing horizon, producing the oldest fossil records of the two major Mesozoic avian groups Enantiornithes and Ornithuromorpha.

Nature and evolution of the lithospheric mantle revealed by water contents and He-Ar isotopes of peridotite xenoliths from Changbaishan and Longgang basalts in Northeast China.

The nature and evolution of the lithospheric mantle underlying Northeast (NE) China were investigated by assessing the mineral chemistry, water contents, and noble gas (He-Ar) isotopes of peridotite xenoliths captured by Cenozoic basalts from the Changbaishan and Longgang regions. The xenoliths, which have 863-1141 °C equilibration temperatures, primarily comprise spinel lherzolites and rare spinel harzburgites. The Mg (Fo) values of olivine in the peridotite xenoliths vary from 86.

Discovery of Coumarin as Microtubule Affinity-Regulating Kinase 4 Inhibitor That Sensitize Hepatocellular Carcinoma to Paclitaxel.

Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide. Nowadays, pharmacological therapy for HCC is in urgent needs. Paclitaxel is an effective drug against diverse solid tumors, but commonly resisted in HCC patients.

Novel ROR1 inhibitor ARI-1 suppresses the development of non-small cell lung cancer.

Limited drug response and severe drug resistance confer the high mortality of non-small-cell lung cancer (NSCLC), a leading cause of cancer death worldwide. There is an urgent need for novel treatment against NSCLC. Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is aberrantly overexpressed and participats in NSCLC development and EGFR-TKIs-induced drug resistance.

Discovery of 4,6-bis(benzyloxy)-3-phenylbenzofuran as a novel Pin1 inhibitor to suppress hepatocellular carcinoma via upregulating microRNA biogenesis.

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) participates in diverse cancer-associated signaling pathways, playing an oncogenic role in multiple human cancers, including hepatocellular carcinoma (HCC). Our recent works clarify that Pin1 modulates miRNAs biogenesis by interacting with ERK-phosphorylated exportin-5 (XPO5) and changing XPO5 conformation, giving a potential target for HCC treatment. Herein, we discover 4,6-bis(benzyloxy)-3-phenylbenzofuran (TAB29) as a novel Pin1 inhibitor that targets Pin1 PPIase domain.

New SIMS U-Pb age constraints on the largest lake transgression event in the Songliao Basin, NE China.

The largest lake transgression event (LTE) associated with lake anoxic events (LAE) and periodic seawater incursion events (SWIE) in the Songliao Basin, northeastern China, occurred during deposition of the Cretaceous Nenjiang Formation. The Yaojia-Nenjiang Formation boundary (YNB) marks the beginning of the LTE, as well as LAE and SWIE. However, there is an absence of direct radioisotopic dating, and therefore the age of the YNB, as well as the beginning of LTE, together with their relationship with other geological events, is strongly debated.