Combinatory glycoengineering of monoclonal antibodies and its application in cancer therapy: a narrative review.

Background And Objective: The application of immunotherapy, especially in terms of recombinant monoclonal antibodies (mAbs), is a revolution in the pharmaceutical industry field. Glycosylation plays an essential role in the structures and functions of mAbs, which must be carefully monitored and designed throughout their entire lifespan to ensure safety and efficacy. This review aimed to summarize the current status of the glycoengineering of mAbs for providing reference for the pharmaceutical industry.

A regenerable sorbent composed of a zeolite imidazolate framework (ZIF-8), FeO and graphene oxide for enrichment of atorvastatin and simvastatin prior to their determination by HPLC.

Graphene oxide (GO), nanosized FeO and zeolite imidazolate framework-8 (ZIF-8) were hybridized as a multifunctional sorbent for use in microextraction. The sorbent was characterized by SEM, TEM, XRD and FTIR. The composite is porous, has a high specific surface (> 600 m·g) and is paramagnetic.

One-pot sustainable synthesis of magnetic MIL-100(Fe) with novel FeO morphology and its application in heterogeneous degradation.

A novel, rapid and simple method is described for the synthesis of magnetic MIL-100(Fe) with novel FeO morphology, which significantly improved the sustainability of conventional fabrication processes in several aspects. The magnetic MOFs were prepared (i) in one pot (instead of multiple steps), (ii) at room temperature (instead of temperatures over 150 °C), (iii) within a few hours with excellent yield (instead of in few days with low productivity) and (iv) in the absence of any corrosive inorganic acid and organic reagent. The materials were tested in the industrially demanded photocatalytic and photo-Fenton degradation of sodium sulfadiazine.

Molecularly imprinted polymers based stir bar sorptive extraction for determination of cefaclor and cefalexin in environmental water.

Although stir bar sportive extraction was thought to be a highly efficiency and simple pretreatment approach, its wide application was limited by low selectivity, short service life, and relatively high cost. In order to improve the performance of the stir bar, molecular imprinted polymers and magnetic carbon nanotubes were combined in the present study. In addition, two monomers were utilized to intensify the selectivity of molecularly imprinted polymers.