Effect of Spp1 on nerve degeneration and regeneration after rat sciatic nerve injury.

Background: Wallerian degeneration (WD) in injured peripheral nerves is associated with a large number of up- or down-regulated genes, but the effects of these changes are poorly understood. In our previous studies, we reported some key factors that are differentially expressed to activate nerve degeneration and regeneration during WD. Here, we determined the effects of secreted phosphoprotein 1 (Spp1) on WD after rat sciatic nerve injury.

The effects of claudin 14 during early Wallerian degeneration after sciatic nerve injury.

Claudin 14 has been shown to promote nerve repair and regeneration in the early stages of Wallerian degeneration (0-4 days) in rats with sciatic nerve injury, but the mechanism underlying this process remains poorly understood. This study reported the effects of claudin 14 on nerve degeneration and regeneration during early Wallerian degeneration. Claudin 14 expression was up-regulated in sciatic nerve 4 days after Wallerian degeneration.

Differential gene expression in proximal and distal nerve segments of rats with sciatic nerve injury during Wallerian degeneration.

Wallerian degeneration is a subject of major interest in neuroscience. A large number of genes are differentially regulated during the distinct stages of Wallerian degeneration: transcription factor activation, immune response, myelin cell differentiation and dedifferentiation. Although gene expression responses in the distal segment of the sciatic nerve after peripheral nerve injury are known, differences in gene expression between the proximal and distal segments remain unclear.

Protein expression profiling during wallerian degeneration after rat sciatic nerve injury.

Introduction: Wallerian degeneration (WD) is an important area of research in modern neuroscience. Many protein expressions are regulated by differentially expressed genes in WD, but the precise mechanisms are elusive.

Methods: In this study, we profiled differentially expressed proteins in WD after rat sciatic nerve injury using an antibody array.

Signal flow and pathways in response to early Wallerian degeneration after rat sciatic nerve injury.

Wallerian degeneration (WD) remains a subject of critical research interest in modern neurobiology. WD is a process which a large number of genes are differentially regulated, especially the early response to activate nerve degeneration and regeneration, but the precise mechanisms remain elusive. In this study, we report the signal pathways, key regulate recurrent neural networks and signal flow in the early WD.